Protein Alignment smid and YTA6

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_015251.1
• Gene: YTA6 / 856031
• SGDID: S000005995
• Length: 754
• Species: Saccharomyces cerevisiae
• Alignment Length: 864
• Identity: 221/864 - (25%)
• Similarity: 338/864 - (39%)
• Gaps: 212/864 - (24%)

  Fly   171 VAAKKVAKPNTIHVSSSEAIQKLHQVVGNRAKNLSE---------DAVPRSKDHRNVPGLYQQLH 226
            :|.:|.:.|....::.|  :|.|:.||.|:.|||::         |.|...|.|:|:..|...::
Yeast     1 MAHEKFSIPENFTLAQS--LQLLYSVVKNQYKNLADLIINSKGNKDTVTYGKIHKNLDTLLVYVN 63

  Fly   227 QNQSRDRLRKFKR---------DLEVQHP-----TESFRDIGGMDSTLKELCEMLI--HIKSPEF 275
            :.     |||.::         :|.|.||     .|.|:.:|......:...|.|:  ...||.
Yeast    64 EG-----LRKIEKTYTLKKGLGNLVVDHPELRSIIEDFQILGQDIRIARRKAETLMAEGNGSPS- 122

  Fly   276 YFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAI 340
                  |.|...:|....|.|..|......|..:..|.|....|.......::..|.|:
Yeast   123 ------LSSSSSVLGLGTGNGLRFPKLWRMGSKRDKLKEADEKEAKINKQADNIRRARK------ 175

  Fly   341 GYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPG 405
                    ::|...:|...|: .:|:|.:     ...|..||..|..:..|.       ..|:.
Yeast   176 --------LEEEKKLGAKLQY-ERDLELQ-----REKLIELKVKEKVEFEVA-------QKLEE- 218

  Fly   406 LRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAA-- 468
             .|:.|.:.|       ||.|.:..:.:...|..:.|.||...|.|       |..:..|:::
Yeast   219 -ERVKREEEE-------RKHREQAEKKRISTLKHERKTNYKSRASL-------DNFSSSSKSSGK 268

  Fly   469 --SVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGD 531
              :..:||||                   ||....|.:...|||  .|..|.|:...|.|.....
Yeast   269 IDNSLIKRRS-------------------LDVVRTSGERVRTPV--RKSMEAAEIGMAAQLAWSQ 312

  Fly   532 KETSA---KDKSEGDSPN------IETP--------KKATNGNSSIKSP---QKTPKKSAEKPTD 576
            .:..|   |..:.|...|      ..||        ||.|.....||||   ::..|.|...||:
Yeast   313 YQNGANHSKVSNNGSHSNELQIRYKPTPPLKKRYDYKKPTVNRPIIKSPTLNRQNSKSSRNIPTN 377

  Fly   577 AAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELT-----------------------NFL 618
            :.:........:..:..||.::.||       |.|...|                       :.|
Yeast   378 SKLKASKSNTNKVSRRNEQNLEPSS-------PVLVSATAVPAESKPMRSKSGTPDKESSASSSL 435

  Fly   619 DNPPEEF------ADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLA 677
            |:..|:.      .|.|.|..:::              |..:|.....|:||..|...:..||.|
Yeast   436 DSRKEDILKSVQGVDRNACEQILN--------------EILVTDEKVYWEDIAGLRNAKNSLKEA 486

  Fly   678 VLAPVKYPEMLERLGLTAP-SGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESE 741
            |:.|...|::.:  ||..| .|:||.||||.|||::|||:|.|:...|.||....|::.|:||||
Yeast   487 VVYPFLRPDLFK--GLREPVRGMLLFGPPGTGKTMIAKAVATESNSTFFSVSASSLLSKYLGESE 549

  Fly   742 RAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGV-------EERK 799
            :.|||.|..|:..:|.:||.||.||:...|||  :.|.|..||..:||.:...:       |:|.
Yeast   550 KLVRALFYMAKKLSPSIIFIDEIDSMLTARSD--NENESSRRIKTELLIQWSSLSSATAQSEDRN 612

  Fly   800 G-----VYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILK---ATTKNGKRPVLADD 856
            .     |.:|.|||.|..||.|..|  |....||:..|:...|...||   |..||.     ..|
Yeast   613 NTLDSRVLVLGATNLPWAIDDAARR--RFSRKLYIPLPDYETRLYHLKRLMAKQKNS-----LQD 670

  Fly   857 VDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGD----TNLDDL-CVRSQHFQEALQQLRP 916
            :|.:.|...|||::|:||..|.|:|:|..:|   :.||    .:.|.: .:..:.||.||..::.
Yeast   671 LDYELITEMTEGFSGSDLTSLAKEAAMEPIR---DLGDKLMFADFDKIRGIEIKDFQNALLTIKK 732

  Fly   917 SVNEQDRKIYDKLRLKYAA 935
            ||:.:..:.|::...|:.:
Yeast   733 SVSSESLQKYEEWSSKFGS 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247
		CDC48	<242..933	CDD:273521	198/771 (26%)
YTA6	NP_015251.1	PTZ00108	<158..412	CDD:240271	67/324 (21%)
		RecA-like_VPS4-like	473..645	CDD:410917	70/177 (40%)
		AAA_lid_3	670..714	CDD:465537	16/46 (35%)
		Vps4_C	<718..750	CDD:462762	8/31 (26%)