Protein Alignment smid and PEX6

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_014070.1
• Gene: PEX6 / 855387
• SGDID: S000005273
• Length: 1030
• Species: Saccharomyces cerevisiae
• Alignment Length: 781
• Identity: 211/781 - (27%)
• Similarity: 323/781 - (41%)
• Gaps: 211/781 - (27%)

  Fly   199 NRAKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKEL 263
            ||.|.::.:...|    |.:|         .||..|:::          ..|.:....|..:...
Yeast   412 NRTKLITTNITNR----RPLP---------LSRSNLQRY----------YGFAETFYYDLHIFPY 453

  Fly   264 CEMLIHIKSPEF-YFQLGLLPSRGLLLHGPP-GCGKTFLARAISGQLKMPLMEIPATELIGGISG 326
            ...|::|....| ..|.|:..:..:|||... ..||..:.|..|..|.:.|:||....|
Yeast   454 VRQLVNILETSFNCSQRGITLNASVLLHSTTNNVGKATMVRFASKYLGIHLLEIDCLSL------ 512

  Fly   327 ESEERIREVFDQAIGY------------SPCVLFIDEIDAI----GGNRQWASKDMERRIVSQLI 375
            .|..|..:...:.|||            ||.|:|:..:|:|    ..|:...:..:::.|..::.
Yeast   513 TSNSRQLDSTSKIIGYIRAKCENVLPYASPAVIFLAHLDSILLDVNANQDPEAIKLQKSINFEMS 577

  Fly   376 SSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVD 440
            ..||:......|.:.|  .:....|.:....|...||  ||.:.:||..:|   |||....|| .
Yeast   578 KLLDDFTFKFPGTTFV--GSVNNIDNVPSSFRSHMRF--EILVPVPSEAQR---LRIFQWYLS-S 634

  Fly   441 PKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDA 505
            .:||.|...::...|:                                .|::..:|.    |..|
Yeast   635 HELNRDVQQKVPVSYM--------------------------------DNISFSSLS----SYSA 663

  Fly   506 GETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKS 570
            |.||:......|||:           ...:|:...|.                         ||.
Yeast   664 GLTPLDIKSIVETAR-----------MTATARFYQES-------------------------KKC 692

  Fly   571 AEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLI 635
            ...|....     :..|:..||      :|.:.:|:
Yeast   693 GWLPQSIL-----ITQEDLSKA------TSKARNEF----------------------------- 717

  Fly   636 DFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVL 700
                ::.:..|.        :|:.||||||.::.::.|:...:..|:|:||:... |:...||:|
Yeast   718 ----SVSIGAPQ--------IPNVTWDDIGGIDFVKGEILDTIDMPLKHPELFTS-GMKKRSGIL 769

  Fly   701 LCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFD 765
            ..||||.||||:|||||....:||.|||||||:|||:||||..||..||:||.:.||||||||.|
Yeast   770 FYGPPGTGKTLMAKAIATNFSLNFFSVKGPELLNMYIGESEANVRRVFQKAREAKPCVIFFDEID 834

  Fly   766 SLCPKRSDGGDGNNSGTRIVNQLLTEMDGVE-ERKGVYILAATNRPDIIDPAILRPGRLDTILYV 829
            |:.|||.:.||......|||:|||.|:||:. :..||:::.||||||::|.|:|||||.|.:||:
Yeast   835 SVAPKRGNQGDSGGVMDRIVSQLLAELDGMSTDADGVFVIGATNRPDLLDEALLRPGRFDKLLYL 899

  Fly   830 GFPE-QSERTEILKATTKNGKRPVLADDVDLDEIAAQTE-GYTGADLAGLVKQASM--------- 883
            |.|: .:::..||:|.|   ::.||.:||.|.|:|.... .|||||...|...|.:
Yeast   900 GIPDTDTKQLNILEALT---RKFVLDNDVKLIELAKLCPFNYTGADFYALCSDAMLNAMSRIARM 961

  Fly   884 ---------------FSLRQSLNNGDTNLD-DLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLK 932
                           .|.|:..:...|..| .:.|:.:.|.:|.:||.|||:..:...|:.:|..
Yeast   962 VEKKVSQHNELTGENISTRRWFDKIATKEDTKVVVKMEDFLKAQEQLTPSVSRAELNHYEAVRAN 1026

  Fly   933 Y 933
            :
Yeast  1027 F 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247
		CDC48	<242..933	CDD:273521	202/736 (27%)
PEX6	NP_014070.1	CDC48	<541..1021	CDD:273521	176/615 (29%)
		RecA-like_PEX6_r2	740..899	CDD:410935	85/159 (53%)