DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and PEX6

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_014070.1	Gene:	PEX6 / 855387	SGDID:	S000005273	Length:	1030	Species:	Saccharomyces cerevisiae

Alignment Length:	781	Identity:	211/781 - (27%)
Similarity:	323/781 - (41%)	Gaps:	211/781 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 NRAKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKEL 263
            ||.|.::.:...|    |.:|         .||..|:::          ..|.:....|..:...
Yeast   412 NRTKLITTNITNR----RPLP---------LSRSNLQRY----------YGFAETFYYDLHIFPY 453

  Fly   264 CEMLIHIKSPEF-YFQLGLLPSRGLLLHGPP-GCGKTFLARAISGQLKMPLMEIPATELIGGISG 326
            ...|::|....| ..|.|:..:..:|||... ..||..:.|..|..|.:.|:||....|
Yeast   454 VRQLVNILETSFNCSQRGITLNASVLLHSTTNNVGKATMVRFASKYLGIHLLEIDCLSL------ 512

  Fly   327 ESEERIREVFDQAIGY------------SPCVLFIDEIDAI----GGNRQWASKDMERRIVSQLI 375
            .|..|..:...:.|||            ||.|:|:..:|:|    ..|:...:..:::.|..::.
Yeast   513 TSNSRQLDSTSKIIGYIRAKCENVLPYASPAVIFLAHLDSILLDVNANQDPEAIKLQKSINFEMS 577

  Fly   376 SSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVD 440
            ..||:......|.:.|  .:....|.:....|...||  ||.:.:||..:|   |||....|| .
Yeast   578 KLLDDFTFKFPGTTFV--GSVNNIDNVPSSFRSHMRF--EILVPVPSEAQR---LRIFQWYLS-S 634

  Fly   441 PKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDA 505
            .:||.|...::...|:                                .|::..:|.    |..|
Yeast   635 HELNRDVQQKVPVSYM--------------------------------DNISFSSLS----SYSA 663

  Fly   506 GETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKS 570
            |.||:......|||:           ...:|:...|.                         ||.
Yeast   664 GLTPLDIKSIVETAR-----------MTATARFYQES-------------------------KKC 692

  Fly   571 AEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLI 635
            ...|....     :..|:..||      :|.:.:|:
Yeast   693 GWLPQSIL-----ITQEDLSKA------TSKARNEF----------------------------- 717

  Fly   636 DFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVL 700
                ::.:..|.        :|:.||||||.::.::.|:...:..|:|:||:... |:...||:|
Yeast   718 ----SVSIGAPQ--------IPNVTWDDIGGIDFVKGEILDTIDMPLKHPELFTS-GMKKRSGIL 769

  Fly   701 LCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFD 765
            ..||||.||||:|||||....:||.|||||||:|||:||||..||..||:||.:.||||||||.|
Yeast   770 FYGPPGTGKTLMAKAIATNFSLNFFSVKGPELLNMYIGESEANVRRVFQKAREAKPCVIFFDEID 834

  Fly   766 SLCPKRSDGGDGNNSGTRIVNQLLTEMDGVE-ERKGVYILAATNRPDIIDPAILRPGRLDTILYV 829
            |:.|||.:.||......|||:|||.|:||:. :..||:::.||||||::|.|:|||||.|.:||:
Yeast   835 SVAPKRGNQGDSGGVMDRIVSQLLAELDGMSTDADGVFVIGATNRPDLLDEALLRPGRFDKLLYL 899

  Fly   830 GFPE-QSERTEILKATTKNGKRPVLADDVDLDEIAAQTE-GYTGADLAGLVKQASM--------- 883
            |.|: .:::..||:|.|   ::.||.:||.|.|:|.... .|||||...|...|.:
Yeast   900 GIPDTDTKQLNILEALT---RKFVLDNDVKLIELAKLCPFNYTGADFYALCSDAMLNAMSRIARM 961

  Fly   884 ---------------FSLRQSLNNGDTNLD-DLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLK 932
                           .|.|:..:...|..| .:.|:.:.|.:|.:||.|||:..:...|:.:|..
Yeast   962 VEKKVSQHNELTGENISTRRWFDKIATKEDTKVVVKMEDFLKAQEQLTPSVSRAELNHYEAVRAN 1026

  Fly   933 Y 933
            :
Yeast  1027 F 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	195/693 (28%)
		AAA	287..418	CDD:278434	35/147 (24%)
		P-loop_NTPase	679..>716	CDD:304359	18/36 (50%)
		AAA	699..830	CDD:278434	78/131 (60%)
PEX6	NP_014070.1	SpoVK	540..1017	CDD:223540	176/612 (29%)
PEX6	NP_014070.1	RecA-like_PEX6_r2	740..899	CDD:410935	85/159 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810