DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and SEC18

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_009636.3	Gene:	SEC18 / 852372	SGDID:	S000000284	Length:	758	Species:	Saccharomyces cerevisiae

Alignment Length:	425	Identity:	128/425 - (30%)
Similarity:	213/425 - (50%)	Gaps:	77/425 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 KKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEY---YEPTLAELTNFLDNPPEEFADPN 629
            |.|.::....::|:| ::.....|||....|......::   ||..:...|.:|   ..||....
Yeast   106 KYSGKQSYLGSIDID-ISFRARGKAVSTVFDQDELAKQFVRCYESQIFSPTQYL---IMEFQGHF 166

  Fly   630 FCLTLIDFVDAIKV--MQPSAK----------------------REGFITV-------------- 656
            |.|.:.: |.||.:  ::|::.                      |:|.:.:
Yeast   167 FDLKIRN-VQAIDLGDIEPTSAVATGIETKGILTKQTQINFFKGRDGLVNLKSSNSLRPRSNAVI 230

  Fly   657 -PDTTWDD--IGALEK-IREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAI- 716
             ||..::|  :|.|:| ..:..:.|..:.:..|.::|:||::...|:||.||||.||||:|:.|
Yeast   231 RPDFKFEDLGVGGLDKEFTKIFRRAFASRIFPPSVIEKLGISHVKGLLLYGPPGTGKTLIARKIG 295

  Fly   717 ----ANEAGINFISVKGPELMNMYVGESERAVRACFQ--------RARNSAPCVIFFDEFDSLCP 769
                |.|..|    |.|||:::.|||.||..:|..|:        :...|:..:|.|||.||:..
Yeast   296 TMLNAKEPKI----VNGPEILSKYVGSSEENIRNLFKDAEAEYRAKGEESSLHIIIFDELDSVFK 356

  Fly   770 KRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQ 834
            :|...|||...|..:|||||.:||||::...:.::..|||.|:||.|:|||||.:..:.:..|::
Yeast   357 QRGSRGDGTGVGDNVVNQLLAKMDGVDQLNNILVIGMTNRKDLIDSALLRPGRFEVQVEIHLPDE 421

  Fly   835 SERTEILKATTKN-GKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLN--NGDTN 896
            ..|.:|....||. .:..:::|||:|.|:||.|:.::||::.||||.||.|::.:::|  .|.|.
Yeast   422 KGRLQIFDIQTKKMRENNMMSDDVNLAELAALTKNFSGAEIEGLVKSASSFAINKTVNIGKGATK 486

  Fly   897 LD-----DLCVRSQHFQEALQQLRPS--VNEQDRK 924
            |:     .|.|..:.|..||..:.|:  ::|:|.|
Yeast   487 LNTKDIAKLKVTREDFLNALNDVTPAFGISEEDLK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	125/418 (30%)
		AAA	287..418	CDD:278434
		P-loop_NTPase	679..>716	CDD:304359	16/36 (44%)
		AAA	699..830	CDD:278434	59/143 (41%)
SEC18	NP_009636.3	CDC48_N	29..98	CDD:215012
		CDC48_2	134..204	CDD:215011	13/73 (18%)
		RecA-like_NSF-SEC18_r1-like	240..416	CDD:410912	68/179 (38%)
		SpoVK	263..758	CDD:223540	99/263 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810