DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and CIP111

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_191228.1	Gene:	CIP111 / 824836	AraportID:	AT3G56690	Length:	1022	Species:	Arabidopsis thaliana

Alignment Length:	858	Identity:	267/858 - (31%)
Similarity:	427/858 - (49%)	Gaps:	137/858 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 SSGDENEDDSNTKTT--NGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHV 184
            ||.::|.:.::|..|  |....::.....|.:|.::.|..........|.::..::|.
plant   228 SSYEQNGNGNSTPKTPANLQKFSSPRPKSPVSPIIEDSVFSCKQRFSSESSIDLREVL------- 285

  Fly   185 SSSEAIQKLHQV------------VGN--RAKNLSE---------DAVPRSKDHRNVPGLYQQ-- 224
             |:|:.:||.|:            .||  ....|||         |..|....:||...:..|
plant   286 -SNESSKKLLQICASSWLYPCSLLYGNFVSVPILSEICIFCVKRADKRPSDTSNRNHAFMINQET 349

  Fly   225 ---LHQN---QSRDRLRKFKRDLEVQHPTE---SFRDIGGMDSTLKELCEMLIHIKSPEFYFQLG 280
               ||..   .|..:.|.|.:.|:......   ....:||:......|.:::...........||
plant   350 KVYLHHTLDLASEIQGRTFVQGLQFDEGENVGCEISKLGGLSKEYAILRDIIDSSSIKNSLSSLG 414

  Fly   281 LLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPC 345
            |.|::|:|:|||||.|||.|||..:....:....:...|:|....||||:.:.|||..|...:|.
plant   415 LRPTKGVLIHGPPGTGKTSLARTFARHSGVNFFSVNGPEIISQYLGESEKALDEVFRSASNATPA 479

  Fly   346 VLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIG 410
            |:|||::|||...|:...:::.:|:|:.|::.:|.:...:   .|||||||.|||.::|.|||.|
plant   480 VVFIDDLDAIAPARKEGGEELSQRMVATLLNLMDGISRTD---GVVVIAATNRPDSIEPALRRPG 541

  Fly   411 RFDHEIAIHIPSRKERREILRIQCEGLSVD-PKLNYDKIAELTPGYVGADLMALVSRAASVAVKR 474
            |.|.||.|.:||..:|.:||.|...|:... ..:..:::|..|.|:|||||.||...||.|.::|
plant   542 RLDREIEIGVPSSTQRSDILHIILRGMRHSLSNIQVEQLAMATHGFVGADLSALCCEAAFVCLRR 606

  Fly   475 RSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDK 539
                     |.....:.:.:.|:         |.|:.:|               ..:....:.|.
plant   607 ---------HLDQSSSSSNLPLE---------EAPIAES---------------SSNMSDISSDS 638

  Fly   540 SEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSND 604
            |:..|..| |....|:|.....|..:|....|:       |:.|              :.:|.::
plant   639 SDSASSCI-TISATTSGAQRSFSLDETVSLVAD-------DIQN--------------NGNSCSE 681

  Fly   605 EYY----EPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIG 665
            :..    |.||:                   :...||.:|...::|||.||..:.||...|:|:|
plant   682 QMLRKQGEHTLS-------------------VGFEDFENAKTKIRPSAMREVILEVPKVNWEDVG 727

  Fly   666 ALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGP 730
            ...:::.:|..||..|.|:.:..:|:|...|||:|:.|||||.|||:|:|:|:||.:||::||||
plant   728 GQNEVKNQLMEAVEWPQKHQDAFKRIGTRPPSGILMFGPPGCSKTLMARAVASEAKLNFLAVKGP 792

  Fly   731 ELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGV 795
            ||.:.:|||||:|||:.|.:||.:||.:|||||.|||...|....||.:...|:::|||.|:||:
plant   793 ELFSKWVGESEKAVRSLFAKARANAPSIIFFDEIDSLASIRGKENDGVSVSDRVMSQLLVELDGL 857

  Fly   796 EERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLD 860
            .:|.||.::|||||||.||.|:|||||.|.:||||.|.:::|..|||...:  |.| .:.|:.|.
plant   858 HQRVGVTVIAATNRPDKIDSALLRPGRFDRLLYVGPPNETDREAILKIHLR--KIP-CSSDICLK 919

  Fly   861 EIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKI 925
            |:|:.|:||||||::.:.::|::.:|.:||     .::::.:|  |.:.|:.|:.|:.....:.:
plant   920 ELASITKGYTGADISLICREAAIAALEESL-----EMEEISMR--HLKAAISQIEPTEILSYKAL 977

  Fly   926 YDKL-RLKYAAPR 937
            .:|. ||.:..|:
plant   978 SEKFQRLVHTDPQ 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	228/652 (35%)
		AAA	287..418	CDD:278434	54/130 (42%)
		P-loop_NTPase	679..>716	CDD:304359	17/36 (47%)
		AAA	699..830	CDD:278434	74/130 (57%)
CIP111	NP_191228.1	SpoVK	413..979	CDD:223540	228/652 (35%)
		AAA	421..551	CDD:278434	55/132 (42%)
		AAA	761..892	CDD:278434	74/130 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194195at2759
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820