DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and IQCA1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001257514.1	Gene:	IQCA1 / 79781	HGNCID:	26195	Length:	830	Species:	Homo sapiens

Alignment Length:	845	Identity:	158/845 - (18%)
Similarity:	291/845 - (34%)	Gaps:	248/845 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 RNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYF--- 277
            ||:..:|.|....|.|..:||.               :.|:...:.||...::.::..||::
Human    61 RNLENVYDQFVHPQKRILIRKV---------------LDGVMGRILELKNEMVELELTEFHYFDD 110

  Fly   278 ---QLGLLPSRGLLLHGPPGCGKTFLARAI--------------------SGQLKMPLMEIP--- 316
               .|.|.|.:   |..|  ..|.||...:                    :..:|.|:..||
Human   111 ILQDLKLAPQQ---LDIP--IPKYFLKEKLEVIKGREKILAQILADSGIDTSDMKYPVKSIPFDE 170

  Fly   317 ATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSL--- 378
            |.:||.......:.|:|.:|.:.|       ::.|.      |...||.:.:::.....::|
Human   171 AVKLIQIAERARQGRLRALFMKQI-------YLQEY------RAKQSKMLGKKVTDTWAAALRIQ 222

  Fly   379 ------------DNLKANE-----------FGQ-SVVVIAATTRPDVLDPGLRRIGRFDHEIAIH 419
                        :.|:..|           |.: |..||.|           .::.|..:|  :.
Human   223 KVWRRFHQRKETEKLREEEMIFLGMNPPPLFNEVSATVIQA-----------EKVDRLRNE--VQ 274

  Fly   420 IPSRKERRE-ILRIQ-----CEGLSVDPKLNYDKI-------AELT---PGYVGADLMALVSRAA 468
            |...::.|| ::.|:     .||:.:...|. |:|       ..||   |.|..      |....
Human   275 IKHEEDYREALVTIKNDLKLIEGVDIKENLQ-DQIRHWFIECRNLTGTFPDYPD------VEEGG 332

  Fly   469 SVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKE 533
            |..:             .|:|.:..|..|.....|:..:......|.|:..|.|:.::|  |.||
Human   333 SAII-------------FSDKTIQQVIEDIIANQEEEEKNKKKKKKKEKQPKKAKKQKK--GTKE 382

  Fly   534 TSAKDKSEGD----SPNIETP--------------KKATNGNSS--------------------- 559
               |:|.|.:    ||::..|              ||..:.|.|
Human   383 ---KNKEEDEKWKMSPSLFLPAMKEGCNAYKEIWMKKDESWNFSQDYDPELIKEEKRKELQSEIR 444

  Fly   560 ----------IKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAEL 614
                      :|:.:....:..|:|..|....|.   ::.||..::|..:....|...:.|:..|
Human   445 IQVDELMRQELKNLKLAVDRERERPVKAGKKKDK---KKGKKGKKKEKKAKKDKDLTADRTIESL 506

  Fly   615 TNFLDNPPEEFADPNFCL-----TLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREEL 674
            .       :|..:....:     .|.|::.....:..:.::.....:|        :|..:|:.:
Human   507 Y-------KELVEEGLLIQALKVNLSDYIGEYSYLGTTLRQVSIEPMP--------SLLDVRQLI 556

  Fly   675 KLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGE 739
            .|..:.|:....:.|:..|.  ..:||.||.|.||.:|..||..|.|.|..::....:...|.|:
Human   557 TLYGIWPLGSAAVHEKAPLV--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGK 619

  Fly   740 S--ERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVY 802
            :  :..:.|.|:.||...|.|::.::.:....|:....:..|...|:...|...:..::....:.
Human   620 NGLQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKKHLPQILKLLKPDDRIL 684

  Fly   803 ILAATNRPDIIDPAILRPGRL-DTILYVGFPEQSERTEILK-ATTKNGKRPVLADDVDLDEIAAQ 865
            |:..|.||  .|..:....:: ..|:.|..|:.:.|..:.| ...:||  .||...:::..:|..
Human   685 IVGTTRRP--FDAELQSFCKVYQKIILVPRPDYASRYVLWKQIIERNG--GVLTSALNVSCLAKV 745

  Fly   866 TEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLCVRSQ--------HFQEALQQLRPSVNEQD 922
            |:|:|...:..:||..               |.|..:|.|        .|..|:..:.|...|::
Human   746 TDGFTQGHIVEVVKGV---------------LTDQRIRRQIHKPLTAVEFITAITSMNPVYKEEE 795

Fly 923 922
Human 796 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	146/785 (19%)
		AAA	287..418	CDD:278434	30/180 (17%)
		P-loop_NTPase	679..>716	CDD:304359	11/36 (31%)
		AAA	699..830	CDD:278434	31/133 (23%)
IQCA1	NP_001257514.1	SpoVK	<497..796	CDD:223540	65/335 (19%)
IQCA1	NP_001257514.1	AAA	579..712	CDD:278434	32/134 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810