DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and pex1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001164306.1	Gene:	pex1 / 793906	ZFINID:	ZDB-GENE-070530-1	Length:	1237	Species:	Danio rerio

Alignment Length:	856	Identity:	231/856 - (26%)
Similarity:	336/856 - (39%)	Gaps:	282/856 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LYSQPRKPLAPKPISEPIDISSGDENEDDSNTKTTNGDGVAAAAAPPPPT-----------PAVQ 155
            |.|.||  ||...:.:|:...:..|.|:|......|.   ..|.:..|.|           |..:
Zfish   397 LKSMPR--LAETVMVQPLQPLAESEKEEDIQMAFLNW---FDAQSHQPLTCLTGRSNIILLPCAE 456

  Fly   156 G------SALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNRAKNLSEDAVPRSKD 214
            |      :.||...::..|:...:..:.:...|.::..                      |.:.|
Zfish   457 GKEEFALTVLKPEQQQEDELFFLSNSLLRKTDIQIARE----------------------PHNSD 499

  Fly   215 HRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQL 279
            ||.        ..|.:.|:...|          .|...:||::...:...:.:.|.       .|
Zfish   500 HRG--------SDNDTEDQCLGF----------PSLSSLGGVEDISRSAFQHISHA-------LL 539

  Fly   280 G-------LLPSRG-----LLLHGPPGCGKTFLARAI----SGQLKMPLMEIPATELIGGISGES 328
            |       :...||     ||:.|..|.||:.|:||:    |..|...:..:....|.|..:...
Zfish   540 GGSLSRELISTGRGLRGGALLITGAKGSGKSSLSRALCRKASEDLDAHIQLLDCKTLKGKRTDTI 604

  Fly   329 EERIREVFDQAIGYSPCVLFIDEIDAIGG-----NRQWASKDMERRIVSQLISSL-DNLKANEFG 387
            .:|:.:||:||:...|.|:.:|::|.:.|     ..:...:.:.|:.:||.:..| |.:......
Zfish   605 RQRLEDVFEQAVWRQPSVVLLDDLDHVAGAATSPEHEHGPEAVLRQHISQSLKDLVDEIVLRSSL 669

  Fly   388 QSVVVIAATTRPDVLDPGLRRIGR---FDHEIAIHIPSRKERREILR--IQCEGLSV-DPKLNYD 446
            .:::|.|.|..  .|.|.|..:..   |.....|..|.:.:|.|||:  |..:...| ...|:.|
Zfish   670 IALIVTAQTEH--ALHPTLTVVQGSHFFQSFCKIPTPDQAQRVEILKSLIVKKSFQVCQTTLDLD 732

  Fly   447 KIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVP 511
            .:|:.|.|::..||..|:.||               :||.:..|           |||
Zfish   733 SVAKETEGFMARDLNLLLERA---------------IHANTLHN-----------SED------- 764

  Fly   512 DSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTD 576

Zfish   765 ----------------------------------------------------------------- 764

  Fly   577 AAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAI 641
                                                                   |:..||..|:
Zfish   765 -------------------------------------------------------LSCKDFRQAL 774

  Fly   642 KVMQPSAKREGFITVPDTTWD------------DIGALEKIREELKLAVLAPVKYPEMLERLGLT 694
                     :||  .|.:.||            .||.|.:.|:.|...:|.|.|||.:...|.|.
Zfish   775 ---------QGF--TPPSLWDAQLQAPSGAGMERIGGLHEARQLLMDIILLPAKYPLLFSSLPLR 828

  Fly   695 APSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVI 759
            ..|||||.|.||.||||||.|:|.|:|:||||:|||||::.|:|.||:|||..||||:.:.||::
Zfish   829 QCSGVLLYGAPGTGKTLLAGAVAKESGMNFISIKGPELLSKYIGASEQAVRDVFQRAQQAKPCIL 893

  Fly   760 FFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLD 824
            ||||||||.|:|  |.|......|:||||||::||||...|||:|||::|||:||||:|||||||
Zfish   894 FFDEFDSLAPRR--GHDNTGVTDRVVNQLLTQLDGVEGLTGVYVLAASSRPDLIDPALLRPGRLD 956

  Fly   825 TILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQS 889
            ..||...|::..|.|||:|.|.:   ..||.|||||:||..||.:|||||..|:..|.:.::..|
Zfish   957 KSLYCPPPDREARLEILRALTHS---VPLAADVDLDQIAGATELFTGADLKALLYNAQLEAIHSS 1018

  Fly   890 LNNGDTNLDDL 900
            |  |...|.||
Zfish  1019 L--GPNLLHDL 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	200/670 (30%)
		AAA	287..418	CDD:278434	35/143 (24%)
		P-loop_NTPase	679..>716	CDD:304359	21/36 (58%)
		AAA	699..830	CDD:278434	83/130 (64%)
pex1	NP_001164306.1	PEX-2N	12..89	CDD:286362
		PEX-1N	101..171	CDD:286361
		SpoVK	559..1026	CDD:223540	194/639 (30%)
		P-loop_NTPase	559..686	CDD:304359	33/128 (26%)
		AAA	833..962	CDD:278434	83/130 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910