DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and SPATA5L1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_076968.2	Gene:	SPATA5L1 / 79029	HGNCID:	28762	Length:	753	Species:	Homo sapiens

Alignment Length:	815	Identity:	247/815 - (30%)
Similarity:	371/815 - (45%)	Gaps:	222/815 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 AAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNRAKNLSEDA 208
            |.||.....|....|.:.|:...| |::....||.|     .:...:..||.|.|..:.:.:...
Human   120 AGAPGARNTAAVLEAAQELLRNRP-ISLGHVVVAPP-----GAPGLVAALHIVGGTPSPDPAGLV 178

  Fly   209 VPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRD----IGGMDSTLKELCEML-I 268
            .||:                         :..|..:.|:|:...    :||:......|.|:| :
Human   179 TPRT-------------------------RVSLGGEPPSEAQPQPEVPLGGLSEAADSLRELLRL 218

  Fly   269 HIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIR 333
            .::.|.....|||...||:||.||||.|||.|.||::.:....|:.:.|..|.|...||:||.:|
Human   219 PLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGAELLAVSAPALQGSRPGETEENVR 283

  Fly   334 EVFDQA---IGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAA 395
            .||.:|   ....|.:||:||:||:...|  .|:..|.|:|:|:::.||....:   :.|||:.|
Human   284 RVFQRARELASRGPSLLFLDEMDALCPQR--GSRAPESRVVAQVLTLLDGASGD---REVVVVGA 343

  Fly   396 TTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADL 460
            |.|||.|||.|||.||||.|:.|..|:.|:|:|||::....:.:...::...:||:|.|||||||
Human   344 TNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKMPISSHVDLGLLAEMTVGYVGADL 408

  Fly   461 MALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAE 525
            .||...||..|:          ||  ||||.
Human   409 TALCREAAMHAL----------LH--SEKNQ---------------------------------- 427

  Fly   526 QKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPK 590
                             |:|.|
Human   428 -----------------DNPVI------------------------------------------- 432

  Fly   591 KAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKRE--GF 653
                         ||                             |||::|.|.:|||:.|.  |.
Human   433 -------------DE-----------------------------IDFLEAFKNIQPSSFRSVIGL 455

  Fly   654 ITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIAN 718
            :.:....|::||.||.::.:||.::..|:|:|....|:|||.|.||||.|||||.||.|.:|:|.
Human   456 MDIKPVDWEEIGGLEDVKLKLKQSIEWPLKFPWEFVRMGLTQPKGVLLYGPPGCAKTTLVRALAT 520

  Fly   719 EAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTR 783
            ....:|:||.|.:|.:.:||:||:.:...|::||.|.|.::|.||.||:...||....|.:...|
Human   521 SCHCSFVSVSGADLFSPFVGDSEKVLSQIFRQARASTPAILFLDEIDSILGARSASKTGCDVQER 585

  Fly   784 IVNQLLTEMDGVE----ERKG---------------VYILAATNRPDIIDPAILRPGRLDTILYV 829
            :::.||.|:|||.    ||:|               |.|:|||||||::|.|:|||||||.|:|:
Human   586 VLSVLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYI 650

  Fly   830 GFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGD 894
            ..|:...|..|||..||.  .|: ..||.|:.:||:|..::||||..|..:|::.:|::   ||
Human   651 PPPDHKGRLSILKVCTKT--MPI-GPDVSLENLAAETCFFSGADLRNLCTEAALLALQE---NG- 708

  Fly   895 TNLDDLCVRSQHFQEALQQLRPSVNEQDRKIYDKL 929
              ||...|:.:||.::|:.::||::.:|..:|:.|
Human   709 --LDATTVKQEHFLKSLKTVKPSLSCKDLALYENL 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	219/671 (33%)
		AAA	287..418	CDD:278434	58/133 (44%)
		P-loop_NTPase	679..>716	CDD:304359	20/36 (56%)
		AAA	699..830	CDD:278434	65/149 (44%)
SPATA5L1	NP_076968.2	CDC48	22..746	CDD:273521	247/815 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..203		5/56 (9%)
		AAA	237..367	CDD:278434	58/134 (43%)
		AAA	501..651	CDD:278434	65/149 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820