DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and spata5l1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_012814742.2	Gene:	spata5l1 / 780248	XenbaseID:	XB-GENE-967079	Length:	798	Species:	Xenopus tropicalis

Alignment Length:	973	Identity:	257/973 - (26%)
Similarity:	399/973 - (41%)	Gaps:	292/973 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 QLVHQAFS----IISESYNLDKVSSSEEDCVSEDSEPPPTNSVMNNMMNSLYSQP------RKPL 110
            :|....||    .::.:::..:.|:....|..:||      |:|:.::..|.|.|      |..|
Frog     2 RLAQSGFSDRSMRLAVNFSEGRSSALSLRCYRQDS------SLMDTVLKCLPSNPDDHCSQRCRL 60

  Fly   111 APKPISEPIDISSGDENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSAL------KRLMEEVPEI 169
            .||.::.                       :.|....|.......||.|      :.|.:...:.
Frog    61 GPKAMAL-----------------------IGAKVGFPVLVSLQSGSCLCTAWPRRDLCDGFVQA 102

  Fly   170 AVAAKKVAKPNTIHVSSSEAIQKLHQVVGNRAKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRL 234
            ........||..:...:...:.::..:...:.:.:|...|.||.|.:........|  ...||.|
Frog   103 DYMCSTSHKPMAVFKDTGICLNQIKSMASTKLRKVSVKVVVRSLDVKRATSEAALL--ETVRDLL 165

  Fly   235 R----------KFKRDLEVQH-------PTESFR------------------------------D 252
            |          ....|..|.|       |..|..                              .
Frog   166 RNVFVLNDYVLSVNADSPVVHIEILDTDPATSNAGLITGKTSIVIKEVITLEWYKHKLQEAPQLK 230

  Fly   253 IGGMDST---LKELCEMLIHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLME 314
            :..||.|   |||:..|.:|.  ||...:|||...:|:||.||||.|||.|.:|::.::...::.
Frog   231 VAAMDDTCASLKEIIHMPLHY--PETMHKLGLPCPKGVLLIGPPGVGKTLLVKAVAREVGAYVIG 293

  Fly   315 IPATELIGGISGESEERIREVFD---QAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLIS 376
            :....:.|...|||||.:|::|:   :|....|.:|||||:||:...|..::...|.|:|:||::
Frog   294 LSGPAIHGSRPGESEENLRKIFEKAREAACSGPALLFIDEVDALCPKRGHSNSAPENRVVAQLLT 358

  Fly   377 SLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDP 441
            .:|.:.::   ..:|.:|||:|||.:||.|||.||||.|:.|..|:.|:|:.||.:....:..|.
Frog   359 LMDGIDSD---NKMVTVAATSRPDAIDPALRRPGRFDREVIIGTPTHKQRQAILEMMISNMPTDR 420

  Fly   442 KLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAG 506
            .::...:|::|.|||||||.||...||..||.:.|:
Frog   421 DVDAAALADVTVGYVGADLTALCRDAAMQAVLQASL----------------------------- 456

  Fly   507 ETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSA 571

Frog   457 ----------------------------------------------------------------- 456

  Fly   572 EKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLID 636
                                      ||              |.|.:..              ..
Frog   457 --------------------------DS--------------LCNLVSR--------------AH 467

  Fly   637 FVDAIKVMQPSAKRE--GFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGV 699
            |.:|.|.::||:.|.  |.:......|:.||.||.|:.:|:.::..|:||||...|:|||.|.||
Frog   468 FYEAFKRIRPSSARSSIGRVEFKPVHWEHIGGLEDIKHKLRQSIEWPMKYPEAFSRMGLTPPKGV 532

  Fly   700 LLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEF 764
            ||.|||||.||.|.||:|.....:|.|:...:|.:.|||:||:.:...|::||.|.|.::|.||.
Frog   533 LLYGPPGCAKTTLVKAVATSCHCSFFSISAADLFSPYVGDSEKTLAQVFRQARASTPAIVFLDEI 597

  Fly   765 DSLCPKRSDGGDGNNSGTRIVNQLLTEMDGV----------------EE------------RKGV 801
            |::...||:...|:....||::.||.|:||:                ||            .|.|
Frog   598 DAMVGARSESRTGSGVQERILSVLLNELDGIGLKTTERRETTRLLESEEHSDEKLEFQEVLNKAV 662

  Fly   802 YILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQT 866
            .|:|||||||.:|.|:|||||||.:||:..|::..|..||:..|.:   ..|||||||:.:||:|
Frog   663 MIVAATNRPDTLDDALLRPGRLDKLLYIPLPDEKARLSILRICTAS---TPLADDVDLETLAAET 724

  Fly   867 EGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKIYDKL 929
            ..|:||||..|.|:|::.:|.:|      .|....|:.:||:::|..::||::.:|..:|.||
Frog   725 PLYSGADLQNLCKEAALTALHES------GLHTSSVKQEHFEKSLTSVKPSLSVKDLGMYKKL 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	3/18 (17%)
		SpoVK	271..919	CDD:223540	206/680 (30%)
		AAA	287..418	CDD:278434	52/133 (39%)
		P-loop_NTPase	679..>716	CDD:304359	23/36 (64%)
		AAA	699..830	CDD:278434	64/158 (41%)
spata5l1	XP_012814742.2	CDC48	<202..781	CDD:273521	216/740 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920