DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and pex1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_004915478.1	Gene:	pex1 / 779516	XenbaseID:	XB-GENE-985415	Length:	1269	Species:	Xenopus tropicalis

Alignment Length:	1058	Identity:	253/1058 - (23%)
Similarity:	393/1058 - (37%)	Gaps:	375/1058 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PLLHDHLITIRVKKYLEEHIGETYL--------------DVKQMTRELMQKYPEYSRRKFGPFRQ 56
            |...||..::...|.:.:.:|:..|              :.:.:.:.|::|..
Frog   224 PTESDHSDSLSSSKSIWDTVGDFLLRSLGRKPALSLGSSETELIKKSLVKKVE------------ 276

  Fly    57 LVHQAFSIISESYNLDKVSSSEEDCVSED--------SEPP---PTNSVMNNMMNSLYSQPRKPL 110
             :...|.:.|...::.|.|....|..:::        .|||   |...|....:..|.|..|:..
Frog   277 -LEAVFRVSSRIPHIVKSSQEYNDYANDNCVHVFLWYPEPPGLVPDIVVTFGTIQELLSPKRRKE 340

  Fly   111 APKPISEPID-----ISSGDENEDDSNTK-----------------------TTNGDGVAAAAAP 147
            :.:..:||.:     |:.|...:.:|:||                       |.||:........
Frog   341 STRKNTEPSEKKPDGIAPGSPKQRNSDTKGHSATVKIVWHGFDDLKDVIEYDTRNGNTHVGKVWV 405

  Fly   148 PP-------------------------PT-----PA--------------------VQGSALKR- 161
            |.                         ||     ||                    ...|.||.
Frog   406 PSQLRKKLNINISSAVRIHSHDSVLRLPTSLTLQPAQTLDRNIHEDEIKAAFSTWLQSNSTLKMP 470

  Fly   162 ------------LMEEVPEIAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNRAK-NLSEDAVPRSK 213
                        |.:||.:..:...|:...     ||.:....|...:..:.| :::.:..|..:
Frog   471 WIAGNTGYIQIILKDEVSDFFIILDKLDLQ-----SSQDDFYMLCPSIMEKTKIHVNFEPAPSEE 530

  Fly   214 DHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHI-----KSP 273
            .||:       ||.:|:...|:              .:::||:....|...:.::|.     .|.
Frog   531 SHRH-------LHADQNLLYLK--------------LQNLGGVSKLGKSCYDHVVHCLLGRPLSR 574

  Fly   274 EFYFQLGLLPSRGLLLHGPPGCGKTFLARAI----SGQLKMPLMEIPATELIGGISGESEERIRE 334
            :.......|.|.|:||.||.|.||:.||:|:    |.||:..:.||....|.|.......:.:.|
Frog   575 QLVASASGLRSGGVLLCGPKGSGKSTLAKALCKEASEQLEAHVEEIDCKLLKGKNVENIIQTLEE 639

  Fly   335 VFDQAIGYSPCVLFIDEIDAIGG---------------NRQ--WASKDMERRIVSQLISSLDNLK 382
            .|::|....|.|:.:|::|.|.|               ::|  :..||:.:.|:     |:|.|
Frog   640 AFEEAAWRQPSVILLDDLDQIAGVASSPELEQSPEATQSKQLAYVLKDLMKNII-----SMDTL- 698

  Fly   383 ANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHI---------PSRKERREILRIQCEG-L 437
                   |.:||.......|:|.|      ..|...|:         |:::.|.|:||...|. |
Frog   699 -------VSLIATCQSEHSLNPVL------ISEQGTHLFQCVKPIPPPTQENRSEMLRCVIENRL 750

  Fly   438 SVDP----KLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDD 498
            |.|.    .|::..:|..|.|:|..|...||.||...:|.:|.:.:..:|
Frog   751 SGDTAFYRDLDFQYLARETEGFVARDFTMLVERAIESSVSKRQICRIEDL--------------- 800

  Fly   499 DEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSP 563

Frog   801 ----------------------------------------------------------------- 800

  Fly   564 QKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADP 628

Frog   801 ----------------------------------------------------------------- 800

  Fly   629 NFCLTLIDFVDAIKVMQPSAKREGFITVP-DTTWDDIGALEKIREELKLAVLAPVKYPEMLERLG 692
              .|:..||..|:|...|.:.|...:..| ...|:.:|.|..||:.||..:..|.||||:...|.
Frog   801 --VLSTTDFQRALKGFTPLSLRNAQLHKPKKQDWNMVGGLHDIRQVLKDTIELPAKYPELFANLP 863

  Fly   693 LTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPC 757
            :...|||||.|.||.||||||..||:|:.:||||:|||||::.|:|.||:|||..|.||:.:.||
Frog   864 IRHRSGVLLYGAPGTGKTLLAGVIAHESRMNFISIKGPELLSKYIGASEQAVRDVFTRAQAAKPC 928

  Fly   758 VIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGR 822
            ::|||||||:.|:|  |.|......|:|||:||::||||..:|||:||||:|||:||||:|||||
Frog   929 ILFFDEFDSIAPRR--GHDNTGVTDRVVNQMLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGR 991

  Fly   823 LDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLR 887
            ||..||...|:|..|.||||..:.:   .:|.::|||..||:.|:.:|||||..|:..|.:.::.
Frog   992 LDECLYCPPPDQDSRFEILKGLSHS---MLLDENVDLKHIASLTDYFTGADLKALLYNAQLEAIH 1053

  Fly   888 QSL-------NNGDTNLD 898
            .:|       ||..::.|
Frog  1054 TNLSVTVPQDNNSGSDSD 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	10/78 (13%)
		SpoVK	271..919	CDD:223540	195/671 (29%)
		AAA	287..418	CDD:278434	40/151 (26%)
		P-loop_NTPase	679..>716	CDD:304359	20/36 (56%)
		AAA	699..830	CDD:278434	80/130 (62%)
pex1	XP_004915478.1	PEX-2N	11..93	CDD:370393
		PEX-1N	99..174	CDD:370392
		CDC48	<587..1052	CDD:273521	188/635 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910