Protein Alignment smid and Iqca1

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_001355651.1
• Gene: Iqca1 / 74918
• MGIID: 1922168
• Length: 838
• Species: Mus musculus
• Alignment Length: 848
• Identity: 151/848 - (17%)
• Similarity: 285/848 - (33%)
• Gaps: 246/848 - (29%)

  Fly   216 RNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYF--- 277
            ||:..:|.|:...|.|..:||.               :.|:...:.||...::.::..||::
Mouse    54 RNMENVYDQIVHPQKRMLIRKV---------------LDGVMGRILELKNEMVELEMTEFHYFDD 103

  Fly   278 ---QLGLLPSR---------------------GLLLHGPPGCGKT----FLARAISGQLKMPLME 314
               .|.|.|.:                     .:|......||..    :.|::|:.:..:.|::
Mouse   104 ILQDLKLSPQQLDVPIPRYFLKERLEVIKGREKILARILTECGLNLPVKYAAKSIALEEAVKLIQ 168

  Fly   315 IPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDME---RRIVSQLIS 376
            |......|        |:|.:|.:.|       |:.|..|         |:|:   .|::...::
Mouse   169 IAERARQG--------RLRALFMKQI-------FLQECRA---------KEMKLLGHRLLDTKLA 209

  Fly   377 SLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDP 441
            :|.                          ::::.|..|:....:..|:|....|     |:...|
Mouse   210 ALQ--------------------------IQKVWRGFHQCKKTVKEREEEMVFL-----GMKPSP 243

  Fly   442 KLNYDKIAELTPGYVGADLM-----------------ALVSRAASVA------VKRRSMKKFREL 483
            ..|     |::...|.:..:                 |||:....:.      :|.....:.|:.
Mouse   244 LFN-----EVSDAIVQSKQVTNLRDEVQLKHEQDYQEALVNIKEDLKMLEGPDIKEHLQDQIRQW 303

  Fly   484 HAASEKNMTTVTLDDDEPSEDAGETPVPDSK------GEETAKDAEAE----QKVDGDKETSA-- 536
            .... :|:|. |..|....||.|...:..:|      |:..|...|.|    :|...|||...
Mouse   304 FIEC-RNLTG-TFPDYPNEEDGGSALIFSNKTPEQVMGDIIATQEEEEKLKKKKKKEDKENKGKK 366

  Fly   537 --KDKSEGDSPNIETPKKA-------------------TNGNSSIKSPQKTPKKSAEKPTDAAMD 580
              |:|.|.....:...:||                   ..|||..|.......:|...|.|...:
Mouse   367 GKKEKKEKKEKKVSLKEKAMKDEDEEWKMSPSLFLQLMEEGNSLYKDIWLNKDESWNFPQDYDPE 431

  Fly   581 VDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAEL----TNFLDNPP------------------- 622
               :..||.:|.:|.|:  ....||.....|..|    ...::.||
Mouse   432 ---LIKEEKRKELEMEI--RVQVDELMRQELKNLKLAVNREMEIPPRQKKGKKKNKGRKGRRGKR 491

  Fly   623 -----------------EEFADPNFCL-----TLIDFVDAIKVMQPSAKREGFITVPDTTWDDIG 665
                             :|..:....:     .|.|::.....:..:.::.....:|
Mouse   492 GKKEKDLTADRTIESLYQELVEKGLLIQALKVNLSDYIGEYSYLGTTLRQVAIEPMP-------- 548

  Fly   666 ALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGP 730
            :|..:|:.:.|..:.|:...|:.||..|.  ..:||.||.|.||.:|..||..|.|.|..::...
Mouse   549 SLLDVRQLITLYGILPLGSAEVHERAPLV--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSAL 611

  Fly   731 ELMNMYVGES--ERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMD 793
            .:...|.|::  :..:...|:.||...|.|::..:.:....|:....:......|:...|...:.
Mouse   612 NIAGKYPGKTGLQMMIHLVFKVARQLQPSVVWIQDTEKTFYKKVPQAEKRFEPKRLKRYLPKLLK 676

  Fly   794 GVEERKGVYILAATNRPDIIDPAILRP--GRLDTILYVGFPEQSERTEILK-ATTKNGKRPVLAD 855
            .::....:.|:..|:||  .| |.|:|  .....|:.|..|:.:.|..:.| ...:||.:  |.:
Mouse   677 LLKPDDRILIVGTTHRP--FD-AELQPFCRVYQKIILVPRPDYASRYVLWKEIILRNGGK--LTN 736

  Fly   856 DVDLDEIAAQTEGYTGADLAGLVKQA-SMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVN 919
            .:::..::..|:|:|...:..::|.. :...|||..:...|.::        |...:..:.|...
Mouse   737 SLNISCLSKVTDGFTQGQIVQVIKDVLTERRLRQQAHKPLTAIE--------FITMMTNMNPVYR 793

  Fly   920 EQD 922
            |::
Mouse   794 EEE 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247
		CDC48	<242..933	CDD:273521	143/822 (17%)
Iqca1	NP_001355651.1	P-loop containing Nucleoside Triphosphate Hydrolases	552..711	CDD:476819	39/163 (24%)