DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and Iqca

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001355651.1	Gene:	Iqca / 74918	MGIID:	1922168	Length:	838	Species:	Mus musculus

Alignment Length:	848	Identity:	151/848 - (17%)
Similarity:	285/848 - (33%)	Gaps:	246/848 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 RNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYF--- 277
            ||:..:|.|:...|.|..:||.               :.|:...:.||...::.::..||::
Mouse    54 RNMENVYDQIVHPQKRMLIRKV---------------LDGVMGRILELKNEMVELEMTEFHYFDD 103

  Fly   278 ---QLGLLPSR---------------------GLLLHGPPGCGKT----FLARAISGQLKMPLME 314
               .|.|.|.:                     .:|......||..    :.|::|:.:..:.|::
Mouse   104 ILQDLKLSPQQLDVPIPRYFLKERLEVIKGREKILARILTECGLNLPVKYAAKSIALEEAVKLIQ 168

  Fly   315 IPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDME---RRIVSQLIS 376
            |......|        |:|.:|.:.|       |:.|..|         |:|:   .|::...::
Mouse   169 IAERARQG--------RLRALFMKQI-------FLQECRA---------KEMKLLGHRLLDTKLA 209

  Fly   377 SLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDP 441
            :|.                          ::::.|..|:....:..|:|....|     |:...|
Mouse   210 ALQ--------------------------IQKVWRGFHQCKKTVKEREEEMVFL-----GMKPSP 243

  Fly   442 KLNYDKIAELTPGYVGADLM-----------------ALVSRAASVA------VKRRSMKKFREL 483
            ..|     |::...|.:..:                 |||:....:.      :|.....:.|:.
Mouse   244 LFN-----EVSDAIVQSKQVTNLRDEVQLKHEQDYQEALVNIKEDLKMLEGPDIKEHLQDQIRQW 303

  Fly   484 HAASEKNMTTVTLDDDEPSEDAGETPVPDSK------GEETAKDAEAE----QKVDGDKETSA-- 536
            .... :|:|. |..|....||.|...:..:|      |:..|...|.|    :|...|||...
Mouse   304 FIEC-RNLTG-TFPDYPNEEDGGSALIFSNKTPEQVMGDIIATQEEEEKLKKKKKKEDKENKGKK 366

  Fly   537 --KDKSEGDSPNIETPKKA-------------------TNGNSSIKSPQKTPKKSAEKPTDAAMD 580
              |:|.|.....:...:||                   ..|||..|.......:|...|.|...:
Mouse   367 GKKEKKEKKEKKVSLKEKAMKDEDEEWKMSPSLFLQLMEEGNSLYKDIWLNKDESWNFPQDYDPE 431

  Fly   581 VDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAEL----TNFLDNPP------------------- 622
               :..||.:|.:|.|:  ....||.....|..|    ...::.||
Mouse   432 ---LIKEEKRKELEMEI--RVQVDELMRQELKNLKLAVNREMEIPPRQKKGKKKNKGRKGRRGKR 491

  Fly   623 -----------------EEFADPNFCL-----TLIDFVDAIKVMQPSAKREGFITVPDTTWDDIG 665
                             :|..:....:     .|.|::.....:..:.::.....:|
Mouse   492 GKKEKDLTADRTIESLYQELVEKGLLIQALKVNLSDYIGEYSYLGTTLRQVAIEPMP-------- 548

  Fly   666 ALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGP 730
            :|..:|:.:.|..:.|:...|:.||..|.  ..:||.||.|.||.:|..||..|.|.|..::...
Mouse   549 SLLDVRQLITLYGILPLGSAEVHERAPLV--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSAL 611

  Fly   731 ELMNMYVGES--ERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMD 793
            .:...|.|::  :..:...|:.||...|.|::..:.:....|:....:......|:...|...:.
Mouse   612 NIAGKYPGKTGLQMMIHLVFKVARQLQPSVVWIQDTEKTFYKKVPQAEKRFEPKRLKRYLPKLLK 676

  Fly   794 GVEERKGVYILAATNRPDIIDPAILRP--GRLDTILYVGFPEQSERTEILK-ATTKNGKRPVLAD 855
            .::....:.|:..|:||  .| |.|:|  .....|:.|..|:.:.|..:.| ...:||.:  |.:
Mouse   677 LLKPDDRILIVGTTHRP--FD-AELQPFCRVYQKIILVPRPDYASRYVLWKEIILRNGGK--LTN 736

  Fly   856 DVDLDEIAAQTEGYTGADLAGLVKQA-SMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVN 919
            .:::..::..|:|:|...:..::|.. :...|||..:...|.::        |...:..:.|...
Mouse   737 SLNISCLSKVTDGFTQGQIVQVIKDVLTERRLRQQAHKPLTAIE--------FITMMTNMNPVYR 793

  Fly   920 EQD 922
            |::
Mouse   794 EEE 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	139/788 (18%)
		AAA	287..418	CDD:278434	21/137 (15%)
		P-loop_NTPase	679..>716	CDD:304359	13/36 (36%)
		AAA	699..830	CDD:278434	32/134 (24%)
Iqca	NP_001355651.1	SpoVK	<578..797	CDD:223540	50/232 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810