Protein Alignment smid and Nvl

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_080447.1
• Gene: Nvl / 67459
• MGIID: 1914709
• Length: 855
• Species: Mus musculus
• Alignment Length: 980
• Identity: 389/980 - (39%)
• Similarity: 537/980 - (54%)
• Gaps: 180/980 - (18%)

  Fly     1 MKKAKPLLHDHLITIRVKKYLEEHIGETYLDVKQMTRELMQKYP-EYSRRKFGPFRQLVHQAFSI 64
            ||....:..|..:..||.:||..:....|:|...:..:|.:.|. :|.|||...||..|.:.|||
Mouse     1 MKPRPGVFVDRKLKQRVIQYLSSNRCGKYVDTGILASDLQRLYSVDYGRRKRNAFRIQVEKVFSI 65

  Fly    65 IS---ESYNLDKV-------------------SSSEEDCVSEDSEPPPTNSVMNNMMNSLYSQPR 107
            ||   |..||.::                   |.|::|...||...|.:.:.||:.:.|||.:
Mouse    66 ISSEKELKNLKELEDGHLAKRARQDEEDEYTESYSDDDSNMEDYPDPQSANPMNSSLLSLYRR-- 128

  Fly   108 KPLAPKPISEPIDISSGDENEDDSNTKTTNGDGVAAAAAP---------PPPTPA---------- 153
                              .|.:..:|....|...|..:.|         |..|||
Mouse   129 ------------------GNSESVSTTPKWGQREATTSTPLLTSKTGSVPLKTPARESEGGWFID 175

  Fly   154 -VQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNRAKNLSEDAVPRSKDHRN 217
             ..|...:.|..::.:....:||  :.:.|.:....::.:..:....|||......  ::::.:.
Mouse   176 KTPGGKKESLPLDLSDDQSNSKK--QDSEIQILKDSSLLESDKKRKGRAKGKGNKR--KTENLQE 236

  Fly   218 VPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGLL 282
            |.|..:.|.|.:::      .|..|:|.....|.|:||.|:||||:|:||||::.||.|..||::
Mouse   237 VDGEIEALLQKKAK------ARSTELQISNVKFEDVGGNDATLKEVCKMLIHMRHPEVYQHLGVV 295

  Fly   283 PSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCVL 347
            |.||:|||||||||||.||.||:|:|.:|::::.|.|::.|:|||||:::||:||||:..:||::
Mouse   296 PPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFDQAVSNAPCIV 360

  Fly   348 FIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRF 412
            ||||||||...|:.||||||||||:||::.:|:|........|:||.||.|||.|||.|||.|||
Mouse   361 FIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRF 425

  Fly   413 DHEIAIHIPSRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSM 477
            |.|:.:.||....|..||:..|..|.:....|:..:|.||||:||||||||...||..||.|..|
Mouse   426 DREVCLGIPDEAARERILQTLCRKLRLPETFNFCHLAHLTPGFVGADLMALCREAAMCAVNRVLM 490

  Fly   478 KKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEG 542
            |:     .|.:|....:   :..|||                          ||:|
Mouse   491 KQ-----QAQQKKKPEI---EGLPSE--------------------------GDQE--------- 512

  Fly   543 DSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYY 607
                                     ::...:||                        |.:.||
Mouse   513 -------------------------ERLGAEPT------------------------SETQDE-- 526

  Fly   608 EPTLAELTNFL--DNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKI 670
               |..|...|  .:|..|......|:.|.||:.|:..:|||||||||:|||:.||.||||||.|
Mouse   527 ---LQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALAEVQPSAKREGFVTVPNVTWADIGALEDI 588

  Fly   671 REELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNM 735
            |:||.:|:||||:.|:....|||..|:|:||.|||||||||||||:|||:|:||||||||||:||
Mouse   589 RDELIMAILAPVRNPDQFRTLGLGTPAGILLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM 653

  Fly   736 YVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKG 800
            ||||||||||..||||:|||||||||||.|:|||:|||...|  :..|:||||||||||:|.|:.
Mouse   654 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG--ASVRVVNQLLTEMDGLETRQQ 716

  Fly   801 VYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIA-- 863
            |:||||||||||||||||||||||..|:||.|..::|..|||..||||.:|.|.:||:|:.||
Mouse   717 VFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRVAILKTITKNGTKPPLDEDVNLETIAND 781

  Fly   864 AQTEGYTGADLAGLVKQASMFSLRQSL---NNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKI 925
            .:...||||||..||::||:.:|||.:   .|| ....:|.|..:||::|.::::||::.:|:.:
Mouse   782 LRCNCYTGADLTALVREASLCALRQEITAQKNG-VGAGELKVSHKHFEDAFKKVKPSISIKDQVM 845

  Fly   926 YDKLR 930
            |:.|:
Mouse   846 YEALQ 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247	23/72 (32%)
		CDC48	<242..933	CDD:273521	330/696 (47%)
Nvl	NP_080447.1	Interaction with RPL5. /evidence=ECO:0000250|UniProtKB:O15381	1..219		51/239 (21%)
		Nucleolin_bd	2..72	CDD:465247	22/69 (32%)
		Nucleolar localization signal. /evidence=ECO:0000269|PubMed:21474449	49..52		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..234		28/174 (16%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381	85..88		0/2 (0%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381	217..231		3/15 (20%)
		CDC48	<242..855	CDD:273521	333/715 (47%)
		Interaction with WDR74. /evidence=ECO:0000250|UniProtKB:O15381	266..473		112/206 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..523		10/113 (9%)