DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and Nvl

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_080447.1	Gene:	Nvl / 67459	MGIID:	1914709	Length:	855	Species:	Mus musculus

Alignment Length:	980	Identity:	389/980 - (39%)
Similarity:	537/980 - (54%)	Gaps:	180/980 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKKAKPLLHDHLITIRVKKYLEEHIGETYLDVKQMTRELMQKYP-EYSRRKFGPFRQLVHQAFSI 64
            ||....:..|..:..||.:||..:....|:|...:..:|.:.|. :|.|||...||..|.:.|||
Mouse     1 MKPRPGVFVDRKLKQRVIQYLSSNRCGKYVDTGILASDLQRLYSVDYGRRKRNAFRIQVEKVFSI 65

  Fly    65 IS---ESYNLDKV-------------------SSSEEDCVSEDSEPPPTNSVMNNMMNSLYSQPR 107
            ||   |..||.::                   |.|::|...||...|.:.:.||:.:.|||.:
Mouse    66 ISSEKELKNLKELEDGHLAKRARQDEEDEYTESYSDDDSNMEDYPDPQSANPMNSSLLSLYRR-- 128

  Fly   108 KPLAPKPISEPIDISSGDENEDDSNTKTTNGDGVAAAAAP---------PPPTPA---------- 153
                              .|.:..:|....|...|..:.|         |..|||
Mouse   129 ------------------GNSESVSTTPKWGQREATTSTPLLTSKTGSVPLKTPARESEGGWFID 175

  Fly   154 -VQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNRAKNLSEDAVPRSKDHRN 217
             ..|...:.|..::.:....:||  :.:.|.:....::.:..:....|||......  ::::.:.
Mouse   176 KTPGGKKESLPLDLSDDQSNSKK--QDSEIQILKDSSLLESDKKRKGRAKGKGNKR--KTENLQE 236

  Fly   218 VPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGLL 282
            |.|..:.|.|.:::      .|..|:|.....|.|:||.|:||||:|:||||::.||.|..||::
Mouse   237 VDGEIEALLQKKAK------ARSTELQISNVKFEDVGGNDATLKEVCKMLIHMRHPEVYQHLGVV 295

  Fly   283 PSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCVL 347
            |.||:|||||||||||.||.||:|:|.:|::::.|.|::.|:|||||:::||:||||:..:||::
Mouse   296 PPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFDQAVSNAPCIV 360

  Fly   348 FIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRF 412
            ||||||||...|:.||||||||||:||::.:|:|........|:||.||.|||.|||.|||.|||
Mouse   361 FIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRF 425

  Fly   413 DHEIAIHIPSRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSM 477
            |.|:.:.||....|..||:..|..|.:....|:..:|.||||:||||||||...||..||.|..|
Mouse   426 DREVCLGIPDEAARERILQTLCRKLRLPETFNFCHLAHLTPGFVGADLMALCREAAMCAVNRVLM 490

  Fly   478 KKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEG 542
            |:     .|.:|....:   :..|||                          ||:|
Mouse   491 KQ-----QAQQKKKPEI---EGLPSE--------------------------GDQE--------- 512

  Fly   543 DSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYY 607
                                     ::...:||                        |.:.||
Mouse   513 -------------------------ERLGAEPT------------------------SETQDE-- 526

  Fly   608 EPTLAELTNFL--DNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKI 670
               |..|...|  .:|..|......|:.|.||:.|:..:|||||||||:|||:.||.||||||.|
Mouse   527 ---LQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALAEVQPSAKREGFVTVPNVTWADIGALEDI 588

  Fly   671 REELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNM 735
            |:||.:|:||||:.|:....|||..|:|:||.|||||||||||||:|||:|:||||||||||:||
Mouse   589 RDELIMAILAPVRNPDQFRTLGLGTPAGILLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM 653

  Fly   736 YVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKG 800
            ||||||||||..||||:|||||||||||.|:|||:|||...|  :..|:||||||||||:|.|:.
Mouse   654 YVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETG--ASVRVVNQLLTEMDGLETRQQ 716

  Fly   801 VYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIA-- 863
            |:||||||||||||||||||||||..|:||.|..::|..|||..||||.:|.|.:||:|:.||
Mouse   717 VFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRVAILKTITKNGTKPPLDEDVNLETIAND 781

  Fly   864 AQTEGYTGADLAGLVKQASMFSLRQSL---NNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKI 925
            .:...||||||..||::||:.:|||.:   .|| ....:|.|..:||::|.::::||::.:|:.:
Mouse   782 LRCNCYTGADLTALVREASLCALRQEITAQKNG-VGAGELKVSHKHFEDAFKKVKPSISIKDQVM 845

  Fly   926 YDKLR 930
            |:.|:
Mouse   846 YEALQ 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	23/72 (32%)
		SpoVK	271..919	CDD:223540	311/654 (48%)
		AAA	287..418	CDD:278434	76/130 (58%)
		P-loop_NTPase	679..>716	CDD:304359	24/36 (67%)
		AAA	699..830	CDD:278434	101/130 (78%)
Nvl	NP_080447.1	Interaction with RPL5. /evidence=ECO:0000250\|UniProtKB:O15381	1..219		51/239 (21%)
		Nucleolin_bd	2..72	CDD:293330	22/69 (32%)
		Nucleolar localization signal. /evidence=ECO:0000269\|PubMed:21474449	49..52		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..234		28/174 (16%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O15381	85..88		0/2 (0%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O15381	217..231		3/15 (20%)
		Interaction with WDR74. /evidence=ECO:0000250\|UniProtKB:O15381	266..473		112/206 (54%)
		SpoVK	283..842	CDD:223540	311/658 (47%)
		AAA	300..432	CDD:278434	76/131 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..523		10/113 (9%)
		AAA	617..747	CDD:278434	102/131 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848596
Domainoid	1	1.000	211	1.000	Domainoid score	I2806
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1902
Inparanoid	1	1.050	650	1.000	Inparanoid score	I784
Isobase	1	0.950	-	0	Normalized mean entropy	S933
OMA	1	1.010	-	-		QHG53526
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102053
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1718
SonicParanoid	1	1.000	-	-		X2802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740