Protein Alignment smid and Afg2a

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_001156983.1
• Gene: Afg2a / 57815
• MGIID: 1927170
• Length: 893
• Species: Mus musculus
• Alignment Length: 880
• Identity: 272/880 - (30%)
• Similarity: 420/880 - (47%)
• Gaps: 202/880 - (22%)

  Fly    66 SESYNLDKVSSSE----EDCVSEDSEPPPTNSVMNNMMNSLYSQPRKPLAPKPISEPIDISSGDE 126
            ::...|.|:.|:.    :...||.|....::..::..::.|  ..::|.:|...|.|.
Mouse   197 TDGTTLGKLQSASGTDAQGMASEHSSMESSDVDLSFQLSQL--DLKEPQSPSSQSTPC------- 252

  Fly   127 NEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQ 191
              ..:|.:|.|..|.........|.   .||.|.  :||...:..:.....:.||..||..:.::
Mouse   253 --KPTNDRTVNKAGEVLLDVTQSPR---DGSGLG--LEESTGLKCSFDSSKEGNTQPVSEEKLLK 310

  Fly   192 KLHQVVGNRAKNLSEDAVPRSKDHR-NVPGLYQQLHQNQSRDRLRKF---KRDLEVQHPTESFRD 252
                              |.|...: |....|  ...:.:|..|||.   .::.:.|... ::..
Mouse   311 ------------------PASAGTKSNTDTFY--FISSTTRINLRKICTNSKEQDSQFKV-TYDM 354

  Fly   253 IGGMDSTLKELCEML-IHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIP 316
            |||::|.||.:.|:: :.:|.||.:...|:...|||||:||||.|||.:|||::.::...:..|.
Mouse   355 IGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVIN 419

  Fly   317 ATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNL 381
            ..|:|....||:|.|:|::|.:|....|.::||||:||:...|:.|..::|:|:|:.|::.:|.:
Mouse   420 GPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGI 484

  Fly   382 KANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDP----K 442
            .:......|:|:.||.||..||..|||.||||.||.|.||:.::|.:||:   :.|...|    |
Mouse   485 GSEGSEGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQ---KLLRRVPHLLTK 546

  Fly   443 LNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGE 507
            ....::|....|||||||.||.:.|...|: ||.::|                    :|:
Mouse   547 AELLRLANNAHGYVGADLKALCNEAGLHAL-RRVLRK--------------------QPN----- 585

  Fly   508 TPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAE 572
              :||||.....|
Mouse   586 --LPDSKVAGMVK---------------------------------------------------- 596

  Fly   573 KPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDF 637
                                                                       :||.||
Mouse   597 -----------------------------------------------------------ITLNDF 602

  Fly   638 VDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLC 702
            :..:..::|||.||..|.||:.:|.|||.||.|:.:||.||..|:|:|:...|:|:..|.||||.
Mouse   603 LQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLY 667

  Fly   703 GPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSL 767
            |||||.||::|||:|||:|:||:::|||||||.||||||||||..|::||..||.:|||||.|:|
Mouse   668 GPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDAL 732

  Fly   768 CPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFP 832
            ..:|.......|...|::.||||||||:|:.|.|.:||||||||.||.|::||||:|.|:||..|
Mouse   733 AVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLP 797

  Fly   833 EQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNL 897
            :.:.|.|||.....:  .|: :::|||||:..||:.|:||::..:.|:|::.:|.:       |:
Mouse   798 DAATRREILNLQFHS--MPI-SNEVDLDELVLQTDTYSGAEIIAVCKEAALLALEE-------NI 852

  Fly   898 DDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLK 932
            ...|:..:||.:||..:.|.:.|..|:.|:..:.|
Mouse   853 KADCIMKRHFTQALSIVTPRIPESLRRFYEDYQEK 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247	0/4 (0%)
		CDC48	<242..933	CDD:273521	239/696 (34%)
Afg2a	NP_001156983.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		CDC48_N	64..132	CDD:451359
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..227		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..315		20/107 (19%)
		CDC48	<323..889	CDD:273521	244/720 (34%)