DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and Spata5

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001156983.1	Gene:	Spata5 / 57815	MGIID:	1927170	Length:	893	Species:	Mus musculus

Alignment Length:	880	Identity:	272/880 - (30%)
Similarity:	420/880 - (47%)	Gaps:	202/880 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 SESYNLDKVSSSE----EDCVSEDSEPPPTNSVMNNMMNSLYSQPRKPLAPKPISEPIDISSGDE 126
            ::...|.|:.|:.    :...||.|....::..::..::.|  ..::|.:|...|.|.
Mouse   197 TDGTTLGKLQSASGTDAQGMASEHSSMESSDVDLSFQLSQL--DLKEPQSPSSQSTPC------- 252

  Fly   127 NEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQ 191
              ..:|.:|.|..|.........|.   .||.|.  :||...:..:.....:.||..||..:.::
Mouse   253 --KPTNDRTVNKAGEVLLDVTQSPR---DGSGLG--LEESTGLKCSFDSSKEGNTQPVSEEKLLK 310

  Fly   192 KLHQVVGNRAKNLSEDAVPRSKDHR-NVPGLYQQLHQNQSRDRLRKF---KRDLEVQHPTESFRD 252
                              |.|...: |....|  ...:.:|..|||.   .::.:.|... ::..
Mouse   311 ------------------PASAGTKSNTDTFY--FISSTTRINLRKICTNSKEQDSQFKV-TYDM 354

  Fly   253 IGGMDSTLKELCEML-IHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIP 316
            |||::|.||.:.|:: :.:|.||.:...|:...|||||:||||.|||.:|||::.::...:..|.
Mouse   355 IGGLNSQLKAIREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVIN 419

  Fly   317 ATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNL 381
            ..|:|....||:|.|:|::|.:|....|.::||||:||:...|:.|..::|:|:|:.|::.:|.:
Mouse   420 GPEIISKFYGETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGI 484

  Fly   382 KANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDP----K 442
            .:......|:|:.||.||..||..|||.||||.||.|.||:.::|.:||:   :.|...|    |
Mouse   485 GSEGSEGRVLVLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQ---KLLRRVPHLLTK 546

  Fly   443 LNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGE 507
            ....::|....|||||||.||.:.|...|: ||.::|                    :|:
Mouse   547 AELLRLANNAHGYVGADLKALCNEAGLHAL-RRVLRK--------------------QPN----- 585

  Fly   508 TPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAE 572
              :||||.....|
Mouse   586 --LPDSKVAGMVK---------------------------------------------------- 596

  Fly   573 KPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDF 637
                                                                       :||.||
Mouse   597 -----------------------------------------------------------ITLNDF 602

  Fly   638 VDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLC 702
            :..:..::|||.||..|.||:.:|.|||.||.|:.:||.||..|:|:|:...|:|:..|.||||.
Mouse   603 LQGMNDIRPSAMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFNRMGIQPPKGVLLY 667

  Fly   703 GPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSL 767
            |||||.||::|||:|||:|:||:::|||||||.||||||||||..|::||..||.:|||||.|:|
Mouse   668 GPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVREIFRKARAVAPSIIFFDELDAL 732

  Fly   768 CPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFP 832
            ..:|.......|...|::.||||||||:|:.|.|.:||||||||.||.|::||||:|.|:||..|
Mouse   733 AVERGSSSGAGNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLP 797

  Fly   833 EQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNL 897
            :.:.|.|||.....:  .|: :::|||||:..||:.|:||::..:.|:|::.:|.:       |:
Mouse   798 DAATRREILNLQFHS--MPI-SNEVDLDELVLQTDTYSGAEIIAVCKEAALLALEE-------NI 852

  Fly   898 DDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLK 932
            ...|:..:||.:||..:.|.:.|..|:.|:..:.|
Mouse   853 KADCIMKRHFTQALSIVTPRIPESLRRFYEDYQEK 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	0/4 (0%)
		SpoVK	271..919	CDD:223540	227/651 (35%)
		AAA	287..418	CDD:278434	54/130 (42%)
		P-loop_NTPase	679..>716	CDD:304359	19/36 (53%)
		AAA	699..830	CDD:278434	80/130 (62%)
Spata5	NP_001156983.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		CDC48_N	64..132	CDD:304500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..227		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..315		20/107 (19%)
		SpoVK	370..882	CDD:223540	229/663 (35%)
		AAA	390..522	CDD:278434	54/131 (41%)
		AAA	664..796	CDD:278434	81/131 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820