DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and AgaP_AGAP009548

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_001688268.1	Gene:	AgaP_AGAP009548 / 5668090	VectorBaseID:	AGAP009548	Length:	617	Species:	Anopheles gambiae

Alignment Length:	550	Identity:	148/550 - (26%)
Similarity:	226/550 - (41%)	Gaps:	183/550 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   509 PVPDSKGEETAKDAEAEQKVDGDKETSAKDKS------EG---DSPNI----ETPKKAT----NG 556
            ||.|..|.:...:|     :|...:.|||:.:      :|   |:..|    |.|.:|.    ||
Mosquito   121 PVEDRHGAKVFFEA-----LDEFNDVSAKELNATVTMLDGRLEDAEEIFLRLEDPTQANLFAKNG 180

  Fly   557 N---SSIKSPQKTPKKSAEKPTDAAMD-------VDNVAPEEPKKAVEQEVDSSSSNDEYYEPTL 611
            .   :|:|...:.....:..|....:.       ||:....|.....:| ::..|..|..|  .:
Mosquito   181 KFLLTSLKYQLQGCAIMSNNPLSLTVCNKRFRFLVDHAVTAEGNDLTDQ-LNKMSLKDRLY--VI 242

  Fly   612 AELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKL 676
            ...|.               |||:|  |: |..|...::..:      :..:||.|:....|||
Mosquito   243 LRTTK---------------LTLLD--DS-KAAQHGHQQRMY------SLANIGGLDTTISELK- 282

  Fly   677 AVLAPVKYPEMLE-RLGLTAPS--------GVLLCGPPGCGKTLLAKAIA--------------- 717
                     |:|| ..|:.:..        |:||.|..|.|||:|..|:|
Mosquito   283 ---------ELLEMAFGMDSKQTTVGPVSRGILLSGVSGVGKTMLVNALATHYHCHVVRINCSEV 338

  Fly   718 -------NEAGI----------------------------------------NFISV-------- 727
                   :||.:                                        :|:::
Mosquito   339 FSKFYGESEANVSRQFAEVFDVHPKPAIVVVEELHNLCPKSTATDIVKRISQHFLTLLDSLHANV 403

  Fly   728 ---------------KGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDG 777
                           .|.||.:|:|||||||||..|:|||..||.:|||||.|::..:|| ...|
Mosquito   404 RGNRTVVIGTTDSVENGSELFSMWVGESERAVRDLFRRARQVAPSIIFFDEIDAIGGERS-AESG 467

  Fly   778 NNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILK 842
            ::...|::.|||||||||...|.|.|:|||||||:||.|::||||||.|:||..|:.:.|.||.:
Mosquito   468 SSVKERVLAQLLTEMDGVSVLKDVRIVAATNRPDLIDRALMRPGRLDRIVYVRLPDAAAREEIFR 532

  Fly   843 ATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLCVRSQHF 907
            ...|.  .|. |..|||.|:..:|.|.:|:::..:.::|::..|       :::.|...:..:||
Mosquito   533 IKLKT--IPT-ASTVDLAELVRRTAGCSGSEIEAICQEAALKGL-------ESSFDVETIEWEHF 587

  Fly   908 QEALQQLRPSVNEQDRKIYDKLRLKYAAPR 937
            :.||..:||      |...:.|||:   ||
Mosquito   588 EHALGVVRP------RTSPELLRLR---PR 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	142/530 (27%)
		AAA	287..418	CDD:278434
		P-loop_NTPase	679..>716	CDD:304359	13/45 (29%)
		AAA	699..830	CDD:278434	72/215 (33%)
AgaP_AGAP009548	XP_001688268.1	AAA_16	273..411	CDD:289934	22/147 (15%)
		AAA	303..523	CDD:214640	74/220 (34%)
		AAA	<419..521	CDD:278434	60/102 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820