DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment smid and fignl2

DIOPT Version :9

Sequence 1:NP_523959.2 Gene:smid / 38824 FlyBaseID:FBgn0016983 Length:944 Species:Drosophila melanogaster
Sequence 2:NP_001201837.1 Gene:fignl2 / 561837 ZFINID:ZDB-GENE-090313-189 Length:684 Species:Danio rerio


Alignment Length:483 Identity:103/483 - (21%)
Similarity:181/483 - (37%) Gaps:125/483 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 PPPTNSVMNNMMNSLYSQPRKPLAPKPI--------------------SEP--------IDISSG 124
            ||.|......:..| |:.|..|..|.|:                    |||        .:::..
Zfish   230 PPSTYPHQTGLAPS-YTHPTAPYIPSPLPSRPTVVGGSYGYQNSSVGGSEPGGSLKRKAFEMTLD 293

  Fly   125 DENEDDSNTK-------TTNGD-----------GVAAAAAPPPPTPAVQGSALKRLMEEVPEIAV 171
            :|:.|.|..:       .|.||           |....:..|      ||.              
Zfish   294 EEDSDSSRYRKYSYDPMKTGGDSPYGVTDKAGNGFGTGSTDP------QGF-------------- 338

  Fly   172 AAKKVAKPNTIHVSSSEAIQK---LHQVVGNRAKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDR 233
               |.:||::......:.:.|   |..:|........:.:.|.:....| .|..|...||:|:.|
Zfish   339 ---KPSKPSSQSSLEGDEVGKYSGLKPLVSPTYGAAGDYSPPAAMTGEN-GGAEQGFSQNRSQKR 399

  Fly   234 -----------LRKFKRDLEVQHPTESFRDIGG---MDSTLKELCEMLIHIKSPEFYFQLGLLPS 284
                       |....|:|:...|...:.::.|   :.:.|:|  ::|..:..|    ...:.|.
Zfish   400 SDPMKSIEPRMLELVSRELQDCSPAMLWTELAGNCHIKAALEE--DLLWPVLRP----NPAIHPP 458

  Fly   285 RGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCVLFI 349
            :.:||.||.|.|||.|||::|.|:......:....|...:.||:|:.:..:|..|....|.::.:
Zfish   459 KTILLFGPQGGGKTTLARSLSSQIGASFYRLSCATLASKLKGEAEQLLLTLFSVATARQPAMVLL 523

  Fly   350 DEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDH 414
            .|::||          .|..:..||.:.|:.::.|:..| .:|:..|.|||::...|.|.  |..
Zfish   524 SEVEAI----------EEEGLRQQLQAQLEKIQHNQSNQ-FLVVCTTRRPDLIKDSLLRC--FSK 575

  Fly   415 EIAIHIPSRKERREIL--RIQCEGLSVDPKLNYDKIAELTPGYVGADLM-----ALVSRAASVAV 472
            ...|.:|....||.:|  .:..:|.|:..: ....:.:.:.|:...:|:     ||.|.:||.:|
Zfish   576 RYHIGLPDGNTRRHVLLQALAPQGCSLSER-ELSAVLQRSEGFSVWELLQLCQQALASASASASV 639

  Fly   473 KRRSMKKFRELHAASEKNMTTVTLDDDE 500
            ...|:          ..::::.||.|.|
Zfish   640 PLHSL----------PASLSSPTLQDFE 657

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smidNP_523959.2 Nucleolin_bd 2..71 CDD:293330
SpoVK 271..919 CDD:223540 59/237 (25%)
AAA 287..418 CDD:278434 37/130 (28%)
P-loop_NTPase 679..>716 CDD:304359
AAA 699..830 CDD:278434
fignl2NP_001201837.1 AAA 457..583 CDD:214640 39/138 (28%)
AAA 461..581 CDD:278434 38/132 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0464
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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