DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and zgc:153738

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001073437.3	Gene:	zgc:153738 / 558115	ZFINID:	ZDB-GENE-061013-622	Length:	818	Species:	Danio rerio

Alignment Length:	761	Identity:	143/761 - (18%)
Similarity:	266/761 - (34%)	Gaps:	183/761 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 QLHQNQSRDRLR-KFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGLLPSRGL 287
            |:.:...:.||| ||.|::......:...||..:.|....:|...:.               ||
Zfish   170 QVAERARQGRLRAKFMREIHRDSERQKRADIETVSSDQAAVCIQKVW---------------RG- 218

  Fly   288 LLHGPPGCGKTFLARAISGQLKM-----------PLMEIPA-TELIG----GISGESEERIREVF 336
                       |:.|.|:.:|:.           |.:..|: ||||.    .:....:|...:.:
Zfish   219 -----------FMQRKITKRLREEEMIFLGMALDPKLSYPSQTELIAQNNKALRRTRQEEHEDDY 272

  Fly   337 DQAIGYSPCVLFIDEIDAIGGN----------RQWASKDMERRIVSQLISSLDNLKANEFGQSVV 391
            .::||     ..:.::..:.|:          |||.   :|.|   ....|..:....|.|.|.:
Zfish   273 QKSIG-----SVVHQLREVEGSEMKETMKDQIRQWF---IECR---DATGSFPDYPEEEDGGSAL 326

  Fly   392 VIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKE--RREILRIQCEGLSVDPKLNYDKIAELTPG 454
            :.|..|..::.:    .:...:.|.|...|..||  :.:..:.:.|....:|.|      ::.|.
Zfish   327 IFAEKTPEELAE----ELAAKEEEDANKNPKGKEDTKEKAKKGKIEDEEEEPGL------KMLPS 381

  Fly   455 YVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETA 519
            ....||.......:.|...|...|.|.:.|...       .:.:|:..|...|.   ..:.:|..
Zfish   382 ACLPDLERSHKTYSEVWKNRNESKNFSQRHELE-------LIKEDKRKEIEVEI---RKQVDELM 436

  Fly   520 KDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNV 584
            :...|..|:..|||.|.|.|.....      |||   :.|.|..:|....:|::.|::..:
Zfish   437 RQELANWKLAVDKEKSGKVKGAAKK------KKA---SKSAKRKKKDKDLTADRTTESLFE---- 488

  Fly   585 APEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAK 649
                  :.||||:.....|                            :.|.|::.....:..:.:
Zfish   489 ------ELVEQELLKKPEN----------------------------VKLKDYLGDYSYLGTTLR 519

  Fly   650 REGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAK 714
            :.....:|        :|..:|:.:.|..:.|:....:.|:..|.  ..:||.||.|.||.:|..
Zfish   520 QSDIEPMP--------SLSDVRQVVALYAILPLGSQAVHEKSPLV--KTILLVGPSGVGKKMLVH 574

  Fly   715 AIANEAGINFISVKGPELMNMYVGES--ERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDG 777
            ||..|.|.|...:....:...|.|.:  :..:...|:.||...|.||:..:.:.:..::....:.
Zfish   575 AICQETGANLFDLSPLNVAKKYPGRNGLQMMLHLVFKVARLMQPSVIWIGDAEKMFYRKVPKEEK 639

  Fly   778 NNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSER----T 838
            .....|:...|...:..:.....|.|:..|:.|...|...|.. ..:.|:.:..|:.:.|    .
Zfish   640 ELDPKRLKKDLPKILKSIRGEDCVLIVGTTSDPHSADLKSLCK-FYNKIILIPRPDYASRYVMWK 703

  Fly   839 EILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLV------KQASMFSLRQSLNNGDTNL 897
            |::|   |||..  :..|:||..:|..::|||...:..:|      ::...|..|.
Zfish   704 ELIK---KNGGE--VTGDLDLSSLAKISDGYTQGHMVQVVRSILTERRIQQFPKRP--------- 754

  Fly   898 DDLCVRSQHFQEALQQLRPSVNEQDRKIYD--------KLRLKYAA 935
                :.:..|...|.::.|...|::..:.:        |.|:|.|:
Zfish   755 ----LTASEFVSPLARIDPVFQEEEEALKNWYAKTPLGKKRIKAAS 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	127/687 (18%)
		AAA	287..418	CDD:278434	26/156 (17%)
		P-loop_NTPase	679..>716	CDD:304359	11/36 (31%)
		AAA	699..830	CDD:278434	30/132 (23%)
zgc:153738	NP_001073437.3	SpoVK	<557..769	CDD:223540	49/230 (21%)
zgc:153738	NP_001073437.3	AAA	559..692	CDD:278434	30/133 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810