DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and fign

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_021334341.1	Gene:	fign / 553599	ZFINID:	ZDB-GENE-050522-339	Length:	747	Species:	Danio rerio

Alignment Length:	494	Identity:	116/494 - (23%)
Similarity:	200/494 - (40%)	Gaps:	94/494 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 PSEDAGETPVPDS----------------------KGEETAKDAEAEQKVDGDKETS-----AKD 538
            ||..|..||:|.|                      ....|.|.........||.::|     ...
Zfish   269 PSGIAAPTPLPPSTIPGYSYQSHNHAPIAPTPLNGSSANTLKRKAFYMTGQGDMDSSYGNFNYSQ 333

  Fly   539 KSEGDSPNIETPKK----ATNGNSSIKSPQKTPKKSAEKPTDAAMDVDN-----------VAPEE 588
            :....||....|..    :|.||...::...:  ..|.|||..:|..|.           :.|..
Zfish   334 QRSAQSPMYRMPDNSLVDSTRGNGFDRNADTS--SLAFKPTKQSMPTDQQRKFGSQAGRALTPPS 396

  Fly   589 --PKKAVEQEVDSSSSNDEYYEPTLAEL-------------TNFLDNPPEEFADPNFCLTLIDFV 638
              ..|.....:.|..|..::..|.:::.             |....:.|.|....|...:|::.|
Zfish   397 YGSSKGSLGSMRSGESFGKFGSPVMSDHGDDSRQHLPHSIGTATSSSHPAEEQLKNSDASLVEMV 461

  Fly   639 DAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCG 703
             ..:::|.:         |...|.||..||..:..:|..||.|:..|:|...|. |.|..:||.|
Zfish   462 -TTEILQQT---------PPVDWSDIAGLEMAKATIKDEVLWPILRPDMFSGLA-TLPRSILLFG 515

  Fly   704 PPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLC 768
            |.|.|:|||.:.:|::.|..|:.:.|..|:..::||.|:.|:|.|..||...|.|:|..:.|.|.
Zfish   516 PQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFLIARCRQPSVVFISDVDLLL 580

  Fly   769 PKR-SDGGDGNNSGTRIVNQLLTEMDGV----EERKGVYILAATNRPDIIDPAILRPGRLDTILY 828
            ..: |:....|    ||.::||.::|||    ||.  |.::.:|::|:.||.::.|  .....|.
Zfish   581 SSQLSEESPVN----RIKSELLLQLDGVLSSPEEH--VLVVCSTSKPEEIDESLRR--YFVKRLL 637

  Fly   829 VGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNG 893
            |..|:.:.|.:|:....  .:......|.::..:..:|:|::|.|:..|.::|.:..| ..:...
Zfish   638 VPLPDATARHQIISQLL--SQHNYCLSDKEVTLLVQRTDGFSGLDVVRLCQEALVGPL-HGMPGA 699

  Fly   894 DTNLDDLC------VRSQHFQEALQQLRPSVNEQDRKIY 926
            |  |..:.      |..|.|:....:::||:::::...|
Zfish   700 D--LSGMIPGQMRPVSYQDFENVFCKIQPSISQKELDTY 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	115/485 (24%)
		AAA	287..418	CDD:278434
		P-loop_NTPase	679..>716	CDD:304359	16/36 (44%)
		AAA	699..830	CDD:278434	45/135 (33%)
fign	XP_021334341.1	EBV-NA3	<174..300	CDD:332796	7/30 (23%)
		Herpes_UL32	<270..>444	CDD:283680	29/175 (17%)
		SpoVK	<464..734	CDD:223540	80/292 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900