DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and FIGN

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_011509691.1	Gene:	FIGN / 55137	HGNCID:	13285	Length:	785	Species:	Homo sapiens

Alignment Length:	480	Identity:	116/480 - (24%)
Similarity:	204/480 - (42%)	Gaps:	89/480 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 GETPV-PDSKGEETAKDAEAE---QKVDGDKETSAKDKSEGDSPNIETP---------KKATNGN 557
            |.||: |.:....:|...:.:   ....||.::|..:.|.|...:.::|         .....||
Human   325 GLTPIAPSALTNSSASSLKRKAFYMAGQGDMDSSYGNYSYGQQRSTQSPMYRMPDNSISNTNRGN 389

  Fly   558 SSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQE-----------------VDSSSSNDE 605
            ...:|.:.:  ..|.|||...|     :.|:.:|...|.                 ..||.|..:
Human   390 GFDRSAETS--SLAFKPTKQLM-----SSEQQRKFSSQSSRALTPPSYSTAKNSLGSRSSESFGK 447

  Fly   606 YYEPTLAE--------LTNFLDNPPEEFAD----------PNFCLTLIDFVDAIKVMQPSAKREG 652
            |..|.::|        |::.:..|....|.          .|....|||.|....:.|.
Human   448 YTSPVMSEHGDEHRQLLSHPMQGPGLRAATSSNHSVDEQLKNTDTHLIDLVTNEIITQG------ 506

  Fly   653 FITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTA-PSGVLLCGPPGCGKTLLAKAI 716
                |...|:||..|:.::..:|..||.||...:...  |||| |..:||.||.|.|||||.:.|
Human   507 ----PPVDWNDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTALPRSILLFGPRGTGKTLLGRCI 565

  Fly   717 ANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSG 781
            |::.|..|..:.|..|:..::||:|:.:.|.|..||...|.|||..:.|.|.  .|...:.::..
Human   566 ASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLL--SSQVNEEHSPV 628

  Fly   782 TRIVNQLLTEMDGV----EERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILK 842
            :|:..:.|.::|.|    |::  :.::.||::|:.||.::.|  .....|.:..|:.:.|.:|:.
Human   629 SRMRTEFLMQLDTVLTSAEDQ--IVVICATSKPEEIDESLRR--YFMKRLLIPLPDSTARHQIIV 689

  Fly   843 ATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLC------ 901
            ...  .:.....:|.:...:..:|||::|.|:|.|.::|.:..|...   ..|:|..:.
Human   690 QLL--SQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAVVGPLHAM---PATDLSAIMPSQLRP 749

  Fly   902 VRSQHFQEALQQLRPSVNEQDRKIY 926
            |..|.|:.|..:::||:::::..:|
Human   750 VTYQDFENAFCKIQPSISQKELDMY 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	115/471 (24%)
		AAA	287..418	CDD:278434
		P-loop_NTPase	679..>716	CDD:304359	18/37 (49%)
		AAA	699..830	CDD:278434	42/134 (31%)
FIGN	XP_011509691.1	AAA	545..680	CDD:214640	43/140 (31%)
		AAA	548..678	CDD:278434	42/135 (31%)
		Vps4_C	<749..782	CDD:286426	7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810