DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and ATAD2B

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_011531220.1	Gene:	ATAD2B / 54454	HGNCID:	29230	Length:	1511	Species:	Homo sapiens

Alignment Length:	718	Identity:	188/718 - (26%)
Similarity:	302/718 - (42%)	Gaps:	118/718 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 LIHIKSPEFYFQLGLLPSRGLLLHGPPGC--GKTFLARAISGQLKMPLMEIPATELIG-GISGES 328
            |:..|||.        |..|......||.  |.:....:.:...|......||.:..| |.:|.:
Human    11 LLGSKSPG--------PGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGGAGVT 67

  Fly   329 EERIREV-FDQAIGYS----PCVLFIDEIDAI----------GGNRQWASKDMERRIVSQLISSL 378
            .:..|:| .|.::..|    |....:.:.|::          |...:|.....:.|:.||..::|
Human    68 LDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTGQARLTSQPGATL 132

  Fly   379 DNLKANEFGQSVVVIAA-TTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPK 442
            .|      |.|.:.:.: ..|.:....|.......|.|:.....|||.|.|         ||:..
Human   133 PN------GHSGLSLRSHPLRGEKKGDGDLSCINGDMEVRKSCRSRKNRFE---------SVNQS 182

  Fly   443 LNYDKIAELTPGYVGADL---------------------------MALVSRAASVAVKRRSMKKF 480
            |.:|::...|...|..::                           |.:.||     ||||  :|.
Human   183 LLFDQLVNSTAEAVLQEMDNINIRRNRRSGEVERLRMWTDTEFENMDMYSR-----VKRR--RKS 240

  Fly   481 RELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSP 545
            ...::...:|...|:.:.:|.:..:...|:     |:.:.:::.|   |||.|....:..|.|.|
Human   241 LRRNSYGIQNHHEVSTEGEEEARTSKLLPL-----EKISIESQEE---DGDIEVEEAEGEENDRP 297

  Fly   546 -NIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEP----KKAVEQEVDSSSSNDE 605
             |:...|..    ...::|...|... :|..:...|:........    ||......|::||::|
Human   298 YNLRQRKTV----DRYQAPPIVPAHQ-KKRENTLFDIHRSPARRSHIRRKKHAIHSSDTTSSDEE 357

  Fly   606 YYE----PTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGA 666
            .:|    .::|...|..  .|..|...:....::.  :.:||....|..:.........:|.||.
Human   358 RFERRKSKSMARARNRC--LPMNFRAEDLASGILR--ERVKVGASLADVDPMNIDKSVRFDSIGG 418

  Fly   667 LEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAG-----INFIS 726
            |......||..|:.|:.|||:.|:..:..|.|.|..||||.||||:|:|:|||..     :.|..
Human   419 LSHHIHALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFM 483

  Fly   727 VKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTE 791
            .||.:.::.:||||||.:|..|.:|....|.:|||||.|.|.|.||...|..:|.  ||:.||..
Human   484 RKGADCLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSS--IVSTLLAL 546

  Fly   792 MDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADD 856
            |||::.|..:.::.||||.|.||||:.||||.|.......|:|..|..||:..|::. .|.|: |
Human   547 MDGLDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDW-NPKLS-D 609

  Fly   857 VDLDEIAAQTEGYTGADLAGLVKQASMFSLRQ-------SLNNGDTNLDDLCVRSQHFQEALQQL 914
            ..|.|:|.:..||.|||:..|..:|::.:||:       |.:....::..:.:.:|.|..|:|.:
Human   610 AFLGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNI 674

  Fly   915 RPS 917
            .|:
Human   675 VPA 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	187/714 (26%)
		AAA	287..418	CDD:278434	28/149 (19%)
		P-loop_NTPase	679..>716	CDD:304359	17/36 (47%)
		AAA	699..830	CDD:278434	61/135 (45%)
ATAD2B	XP_011531220.1	AAA	447..588	CDD:214640	63/142 (44%)
		AAA	452..586	CDD:278434	61/135 (45%)
		COG5076	866..>1100	CDD:227408
		Bromo_AAA	974..1085	CDD:99957
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810