Protein Alignment smid and ATAD2B

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: XP_047300755.1
• Gene: ATAD2B / 54454
• HGNCID: 29230
• Length: 1522
• Species: Homo sapiens
• Alignment Length: 713
• Identity: 182/713 - (25%)
• Similarity: 296/713 - (41%)
• Gaps: 122/713 - (17%)

  Fly   267 LIHIKSPEFYFQLGLLPSRGLLLHGPPGC--GKTFLARAISGQLKMPLMEIPATELIG-GISGES 328
            |:..|||.        |..|......||.  |.:....:.:...|......||.:..| |.:|.:
Human    11 LLGSKSPG--------PGPGPGAGAEPGATGGSSHFISSRTRSSKTRAASCPAAKAGGSGGAGVT 67

  Fly   329 EERIREV-FDQAIGYS----PCVLFIDEIDAI----------GGNRQWASKDMERRIVSQLISSL 378
            .:..|:| .|.::..|    |....:.:.|::          |...:|.....:.|:.||..::|
Human    68 LDEARKVEVDGSLSDSHVSPPAKRTLKQPDSVCKDKSKSRSTGQREEWNLSTGQARLTSQPGATL 132

  Fly   379 DNLKANEFGQSVVVIAA-TTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPK 442
            .|      |.|.:.:.: ..|.:....|.......|.|:.....|||.|.|         ||:..
Human   133 PN------GHSGLSLRSHPLRGEKKGDGDLSCINGDMEVRKSCRSRKNRFE---------SVNQS 182

  Fly   443 LNYDKIAELTPGYVGADL---------------------------MALVSRAASVAVKRRSMKKF 480
            |.:|::...|...|..::                           |.:.||     ||||.....
Human   183 LLFDQLVNSTAEAVLQEMDNINIRRNRRSGEVERLRMWTDTEFENMDMYSR-----VKRRRKSLR 242

  Fly   481 RELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSP 545
            |..:.....:..:...:::|..|:.|:..|.:::|||..:.....|:...|:.         .:|
Human   243 RNSYGIQNHHEVSTEGEEEESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRY---------QAP 298

  Fly   546 NIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYE-- 608
            .| .|.......:::....::|.:.:.              ...||......|::||::|.:|
Human   299 PI-VPAHQKKRENTLFDIHRSPARRSH--------------IRRKKHAIHSSDTTSSDEERFERR 348

  Fly   609 --PTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIR 671
              .::|...|..  .|..|...:....::.  :.:||....|..:.........:|.||.|....
Human   349 KSKSMARARNRC--LPMNFRAEDLASGILR--ERVKVGASLADVDPMNIDKSVRFDSIGGLSHHI 409

  Fly   672 EELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAG-----INFISVKGPE 731
            ..||..|:.|:.|||:.|:..:..|.|.|..||||.||||:|:|:|||..     :.|...||.:
Human   410 HALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGAD 474

  Fly   732 LMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVE 796
            .::.:||||||.:|..|.:|....|.:|||||.|.|.|.||...|..:|.  ||:.||..|||::
Human   475 CLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSS--IVSTLLALMDGLD 537

  Fly   797 ERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDE 861
            .|..:.::.||||.|.||||:.||||.|.......|:|..|..||:..|::. .|.|: |..|.|
Human   538 NRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDW-NPKLS-DAFLGE 600

  Fly   862 IAAQTEGYTGADLAGLVKQASMFSLRQ-------SLNNGDTNLDDLCVRSQHFQEALQQLRPS 917
            :|.:..||.|||:..|..:|::.:||:       |.:....::..:.:.:|.|..|:|.:.|:
Human   601 LAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNIVPA 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247
		CDC48	<242..933	CDD:273521	182/713 (26%)
ATAD2B	XP_047300755.1	RecA-like_Yta7-like	401..570	CDD:410925	74/170 (44%)
		AAA_lid_3	595..635	CDD:465537	13/39 (33%)
		P-loop containing Nucleoside Triphosphate Hydrolases	759..895	CDD:476819
		COG5076	852..>1081	CDD:227408
		Bromo_AAA	960..1066	CDD:99957