DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and PEX6

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_000278.3	Gene:	PEX6 / 5190	HGNCID:	8859	Length:	980	Species:	Homo sapiens

Alignment Length:	698	Identity:	204/698 - (29%)
Similarity:	321/698 - (45%)	Gaps:	172/698 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 GMDSTLKELCEMLIHIKSPEFYFQLG---LLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIP 316
            |:::.:.|||.:|    .|.  .|.|   |..:..:||.||||||||.:..|....|.:.|:::|
Human   437 GLEALVSELCAVL----KPR--LQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVP 495

  Fly   317 ATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNL 381
            .:.|....||..|.:::.:|.:|....|.||.:..:|.:|.:|....:|      :::::.|.:|
Human   496 CSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGED------ARVMAVLRHL 554

  Fly   382 KANEFGQS----VVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPK 442
            ..||...:    ::|:|.|:|...|...::.  .|.||:.:...|..:|..|||.....|.:..:
Human   555 LLNEDPLNSCPPLMVVATTSRAQDLPADVQT--AFPHELEVPALSEGQRLSILRALTAHLPLGQE 617

  Fly   443 LNYDKIAELTPGYVGADLMALV---SRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSED 504
            :|..::|....|:|..||.||:   ||||...:|...:
Human   618 VNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGL--------------------------- 655

  Fly   505 AGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKK 569
                     .|..|.:| |.|....|
Human   656 ---------AGGLTEED-EGELCAAG--------------------------------------- 671

  Fly   570 SAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTL 634
                                                  .|.|||
Human   672 --------------------------------------FPLLAE--------------------- 677

  Fly   635 IDFVDAIKVMQPS-AKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSG 698
             ||..|::.:|.: ::..|...:|..:|.|:|.|:::::|:...:..|:::||:|. |||.. ||
Human   678 -DFGQALEQLQTAHSQAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLS-LGLRR-SG 739

  Fly   699 VLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDE 763
            :||.||||.||||||||:|.|..:.|:|||||||:|||||:||..||..|.|||.:|||:|||||
Human   740 LLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDE 804

  Fly   764 FDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILY 828
            .|||.|.|...||......|:|:|||.|:||:...:.|:::.||||||::|||:|||||.|.:::
Human   805 LDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVF 869

  Fly   829 VGFPE-QSERTEILKATTKNGKRPVLADDVDL-DEIAAQTEGYTGADLAGLVKQASMFSLRQSLN 891
            ||..| ::.:..:|.|.|:..|   |...|.| :.:.......|||||..|...|...:|::.::
Human   870 VGANEDRASQLRVLSAITRKFK---LEPSVSLVNVLDCCPPQLTGADLYSLCSDAMTAALKRRVH 931

  Fly   892 NGDTNLDD----LCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLKYAA 935
            :.:..|:.    |.:..:...:|..:|:|||:||:...|.:::.|:||
Human   932 DLEEGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAA 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	192/664 (29%)
		AAA	287..418	CDD:278434	39/134 (29%)
		P-loop_NTPase	679..>716	CDD:304359	22/36 (61%)
		AAA	699..830	CDD:278434	76/130 (58%)
PEX6	NP_000278.3	SpoVK	463..967	CDD:223540	191/652 (29%)
		AAA	466..594	CDD:278434	39/135 (29%)
		AAA	743..871	CDD:278434	74/127 (58%)
		Vps4_C	918..977	CDD:286426	12/58 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810