DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment smid and PEX1

DIOPT Version :10

Sequence 1:NP_523959.2 Gene:smid / 38824 FlyBaseID:FBgn0016983 Length:944 Species:Drosophila melanogaster
Sequence 2:NP_000457.1 Gene:PEX1 / 5189 HGNCID:8850 Length:1283 Species:Homo sapiens


Alignment Length:996 Identity:248/996 - (24%)
Similarity:376/996 - (37%) Gaps:338/996 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 FRQLVHQAFSIISESYNLDKVSSSEEDCV-------SEDSEPPPTNSVMNNMMNSLYSQPRK--- 108
            ||....|..||    ||....|...:.|.       .|..:..|:.:|....:..|.|..::   
Human   287 FRVCKSQPPSI----YNASATSVFHKHCAIHVFPWDQEYFDVEPSFTVTYGKLVKLLSPKQQQSK 347

  Fly   109 -------PLAPKPISEPIDISS--GDENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLME 164
                   |...|.:|||:|...  .|.||:|.                       :...|:.:..
Human   348 TKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDE-----------------------KACVLQVVWN 389

  Fly   165 EVPEIAVAAKKVAKPNTIHVSS---SEAIQK-----LHQVV--------------------GNRA 201
            .:.|:..|.|.......:|:..   .:.::|     :|.||                    .|..
Human   390 GLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLP 454

  Fly   202 KNLSEDAVPRSKDHRNVPGLYQQLHQN-----------------QSRDRLRKFKRDLEVQHPTES 249
            |::||:      |.:.|  .|..|.|:                 :::|.|::|  .|.:.|..|.
Human   455 KDISEE------DIKTV--FYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEF--SLSIVHSWEK 509

  Fly   250 FRD-------------------------------------------IGGMDSTLKELCEMLIHI- 270
            .:|                                           :||::|......|.:.|. 
Human   510 EKDKNIFLLSPNLLQKTTIQVLLDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSL 574

  Fly   271 ----KSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAIS----GQLKMPLMEIPATELIGGISGE 327
                .|.:....:..|.:..|||.|..|.||:.||:||.    .:|...:..:....|.|.....
Human   575 LGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLEN 639

  Fly   328 SEERIREVFDQAIGYSPCVLFIDEIDAIGG----NRQWASKDMERRIVSQLISSLDNLKANEF-- 386
            .::.:...|.:|:...|.|:.:|::|.|.|    .....|.|   .:.||.::...|....||  
Human   640 IQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPD---AVQSQRLAHALNDMIKEFIS 701

  Fly   387 -GQSVVVIAATTRPDVLDP------GLRRIGRFDHEIAIHIPSRKERREIL------RIQCEGLS 438
             |..|.:||.:.....|.|      |:.......|   |..|::::|.|||      ::.|: ::
Human   702 MGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQH---IQPPNQEQRCEILCNVIKNKLDCD-IN 762

  Fly   439 VDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSE 503
            ....|:...:|:.|.|:|..|...||.||....:.|:|:                          
Human   763 KFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSI-------------------------- 801

  Fly   504 DAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPK 568
                                           |.::|                             
Human   802 -------------------------------STREK----------------------------- 806

  Fly   569 KSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLT 633
                                                                         ..||
Human   807 -------------------------------------------------------------LVLT 810

  Fly   634 LIDFVDAIKVMQPSAKREGFITVP-DTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPS 697
            .:||..|::...|::.|...:..| |..||.||.|.::|:.|...:..|.||||:...|.:...:
Human   811 TLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRT 875

  Fly   698 GVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFD 762
            |:||.||||.||||||..||.|:.:||||||||||::.|:|.||:|||..|.||:.:.||::|||
Human   876 GILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFD 940

  Fly   763 EFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTIL 827
            ||:|:.|:|  |.|......|:||||||::||||..:|||:||||:|||:||||:|||||||..:
Human   941 EFESIAPRR--GHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCV 1003

  Fly   828 YVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLR----- 887
            |...|:|..|.|||...:.:  .| |||||||..:|:.|:.:|||||..|:..|.:.:|.     
Human  1004 YCPPPDQVSRLEILNVLSDS--LP-LADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLS 1065

  Fly   888 QSLNNGDTNLD-DLCVRSQHF 907
            ..|.:|.::.| ||.:.|..|
Human  1066 SGLQDGSSSSDSDLSLSSMVF 1086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smidNP_523959.2 Nucleolin_bd 2..71 CDD:465247 6/16 (38%)
CDC48 <242..933 CDD:273521 202/744 (27%)
PEX1NP_000457.1 PEX-2N 17..98 CDD:462730
PEX-1N 104..179 CDD:462729
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 346..367 5/20 (25%)
CDC48 <595..1065 CDD:273521 185/628 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1260..1283
Blue background indicates that the domain is not in the aligned region.

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