DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and PEX1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_000457.1	Gene:	PEX1 / 5189	HGNCID:	8850	Length:	1283	Species:	Homo sapiens

Alignment Length:	996	Identity:	248/996 - (24%)
Similarity:	376/996 - (37%)	Gaps:	338/996 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 FRQLVHQAFSIISESYNLDKVSSSEEDCV-------SEDSEPPPTNSVMNNMMNSLYSQPRK--- 108
            ||....|..||    ||....|...:.|.       .|..:..|:.:|....:..|.|..::
Human   287 FRVCKSQPPSI----YNASATSVFHKHCAIHVFPWDQEYFDVEPSFTVTYGKLVKLLSPKQQQSK 347

  Fly   109 -------PLAPKPISEPIDISS--GDENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLME 164
                   |...|.:|||:|...  .|.||:|.                       :...|:.:..
Human   348 TKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDE-----------------------KACVLQVVWN 389

  Fly   165 EVPEIAVAAKKVAKPNTIHVSS---SEAIQK-----LHQVV--------------------GNRA 201
            .:.|:..|.|.......:|:..   .:.::|     :|.||                    .|..
Human   390 GLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLP 454

  Fly   202 KNLSEDAVPRSKDHRNVPGLYQQLHQN-----------------QSRDRLRKFKRDLEVQHPTES 249
            |::||:      |.:.|  .|..|.|:                 :::|.|::|  .|.:.|..|.
Human   455 KDISEE------DIKTV--FYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEF--SLSIVHSWEK 509

  Fly   250 FRD-------------------------------------------IGGMDSTLKELCEMLIHI- 270
            .:|                                           :||::|......|.:.|.
Human   510 EKDKNIFLLSPNLLQKTTIQVLLDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSL 574

  Fly   271 ----KSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAIS----GQLKMPLMEIPATELIGGISGE 327
                .|.:....:..|.:..|||.|..|.||:.||:||.    .:|...:..:....|.|.....
Human   575 LGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLEN 639

  Fly   328 SEERIREVFDQAIGYSPCVLFIDEIDAIGG----NRQWASKDMERRIVSQLISSLDNLKANEF-- 386
            .::.:...|.:|:...|.|:.:|::|.|.|    .....|.|   .:.||.::...|....||
Human   640 IQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPD---AVQSQRLAHALNDMIKEFIS 701

  Fly   387 -GQSVVVIAATTRPDVLDP------GLRRIGRFDHEIAIHIPSRKERREIL------RIQCEGLS 438
             |..|.:||.:.....|.|      |:.......|   |..|::::|.|||      ::.|: ::
Human   702 MGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQH---IQPPNQEQRCEILCNVIKNKLDCD-IN 762

  Fly   439 VDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSE 503
            ....|:...:|:.|.|:|..|...||.||....:.|:|:
Human   763 KFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSI-------------------------- 801

  Fly   504 DAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPK 568
                                           |.::|
Human   802 -------------------------------STREK----------------------------- 806

  Fly   569 KSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLT 633
                                                                         ..||
Human   807 -------------------------------------------------------------LVLT 810

  Fly   634 LIDFVDAIKVMQPSAKREGFITVP-DTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPS 697
            .:||..|::...|::.|...:..| |..||.||.|.::|:.|...:..|.||||:...|.:...:
Human   811 TLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRT 875

  Fly   698 GVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFD 762
            |:||.||||.||||||..||.|:.:||||||||||::.|:|.||:|||..|.||:.:.||::|||
Human   876 GILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFD 940

  Fly   763 EFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTIL 827
            ||:|:.|:|  |.|......|:||||||::||||..:|||:||||:|||:||||:|||||||..:
Human   941 EFESIAPRR--GHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCV 1003

  Fly   828 YVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLR----- 887
            |...|:|..|.|||...:.:  .| |||||||..:|:.|:.:|||||..|:..|.:.:|.
Human  1004 YCPPPDQVSRLEILNVLSDS--LP-LADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLS 1065

  Fly   888 QSLNNGDTNLD-DLCVRSQHF 907
            ..|.:|.::.| ||.:.|..|
Human  1066 SGLQDGSSSSDSDLSLSSMVF 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	6/16 (38%)
		SpoVK	271..919	CDD:223540	194/667 (29%)
		AAA	287..418	CDD:278434	37/147 (25%)
		P-loop_NTPase	679..>716	CDD:304359	19/36 (53%)
		AAA	699..830	CDD:278434	80/130 (62%)
PEX1	NP_000457.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..367		5/20 (25%)
		SpoVK	595..1063	CDD:223540	185/626 (30%)
		AAA	595..731	CDD:278434	36/138 (26%)
		AAA	877..1006	CDD:278434	80/130 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1283
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810