Protein Alignment smid and NVL

DIOPT Version :9

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Alignment Length: 1025
• Identity: 389/1025 - (37%)
• Similarity: 538/1025 - (52%)
• Gaps: 226/1025 - (22%)

  Fly    10 DHLITIRVKKYLEEHIGETYLDVKQMTRELMQKYP-EYSRRKFGPFRQLVHQAFSIIS---ESYN 70
            |:.:..||.:||..:....|:|:..:..:|.:.|. :|.|||...||..|.:.|||||   |..|
Human    10 DNKLKQRVIQYLTSNKCGKYVDIGVLASDLQRVYSIDYGRRKRNAFRIQVEKVFSIISSEKELKN 74

  Fly    71 LDKV------------------------------------------------------SSSEEDC 81
            |.::                                                      |.|::|.
Human    75 LTELEDEHLAKRARQGEEDNDVSLCHPGFSALAQSWLTAVLTSQAQAILPPQPHRYTESYSDDDS 139

  Fly    82 VSEDSEPPPTNSVMNNMMNSLYSQPRKPLAPKPISEPIDISSGDENEDDSNTKTTNGDGVAAAAA 146
            ..||...|.:.:.||:.:.|||   ||       ..|..:|:..|.|....|.:|.... :...:
Human   140 SMEDYPDPQSANHMNSSLLSLY---RK-------GNPDSVSNTPEMEQRETTSSTPRIS-SKTGS 193

  Fly   147 PPPPTPAVQGSALKRLMEEVP---------EIAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNRAK 202
            .|..||| :.|.....:::.|         :::.......||.| .:..|:....|...:..:.|
Human   194 IPLKTPA-KDSEGGWFIDKTPSVKKDSFFLDLSCEKSNPKKPIT-EIQDSKDSSLLESDMKRKGK 256

  Fly   203 NLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEML 267
            ..::.:..:.:|.:.|.|..:.:.|.:::      .|.||.|.....|.|:||.|.||||:|:||
Human   257 LKNKGSKRKKEDLQEVDGEIEAVLQKKAK------ARGLEFQISNVKFEDVGGNDMTLKEVCKML 315

  Fly   268 IHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISG-------------------------- 306
            ||::.||.|..||::|.||:|||||||||||.||.||:|
Human   316 IHMRHPEVYHHLGVVPPRGVLLHGPPGCGKTLLAHAIAGAECSGMITAHCSFDFSGSNDPPASAS 380

  Fly   307 -QLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRI 370
             :|.:|::::.|.|::.|:|||||:::||:|:||:..:||::||||||||...|:.|||||||||
Human   381 QELDLPILKVAAPEIVSGVSGESEQKLRELFEQAVSNAPCIIFIDEIDAITPKREVASKDMERRI 445

  Fly   371 VSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCE 435
            |:||::.:|:|........|:||.||.|||.|||.|||.||||.||.:.||....|..||:..|.
Human   446 VAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEASRERILQTLCR 510

  Fly   436 GLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDE 500
            .|.:....::..:|.||||:||||||||...||..||.|..||    |....:||
Human   511 KLRLPQAFDFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMK----LQEQQKKN---------- 561

  Fly   501 PSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQK 565
                                                        |.:|
Human   562 --------------------------------------------PEME----------------- 565

  Fly   566 TPKKSAEKPTDAAMDVDNVAPEEPKKAVEQE----VDSSSSNDEYYEPTLAELTNFL--DNPPEE 624
                                 :.|.|.|::|    ..:|.:.||     |..|...|  .:|..|
Human   566 ---------------------DLPSKGVQEERLGTEPTSETQDE-----LQRLLGLLRDQDPLSE 604

  Fly   625 FADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLE 689
            ......|:.|.||:.|:..:|||||||||:|||:.||.||||||.|||||.:|:||||:.|:..:
Human   605 EQMQGLCIELNDFIVALSSVQPSAKREGFVTVPNVTWADIGALEDIREELTMAILAPVRNPDQFK 669

  Fly   690 RLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNS 754
            .|||..|:||||.|||||||||||||:|||:|:||||||||||:||||||||||||..||||:||
Human   670 ALGLVTPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNS 734

  Fly   755 APCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILR 819
            |||||||||.|:|||:|||...|  :..|:||||||||||:|.|:.|:|:|||||||||||||||
Human   735 APCVIFFDEVDALCPRRSDRETG--ASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILR 797

  Fly   820 PGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAA--QTEGYTGADLAGLVKQAS 882
            |||||..|:||.|..::|..|||..||||.:|.|..||:|:.||.  :.:.||||||:.||::||
Human   798 PGRLDKTLFVGLPPPADRLAILKTITKNGTKPPLDADVNLEAIAGDLRCDCYTGADLSALVREAS 862

  Fly   883 MFSLRQSL--NNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLR 930
            :.:|||.:  ........:|.|..:||:||.:::|.|::::|:.:|::|:
Human   863 ICALRQEMARQKSGNEKGELKVSHKHFEEAFKKVRSSISKKDQIMYERLQ 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	22/64 (34%)
		SpoVK	271..919	CDD:223540	309/684 (45%)
		AAA	287..418	CDD:278434	76/157 (48%)
		P-loop_NTPase	679..>716	CDD:304359	25/36 (69%)
		AAA	699..830	CDD:278434	101/130 (78%)
NVL	XP_016856867.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158214
Domainoid	1	1.000	210	1.000	Domainoid score	I2813
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1902
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S933
OMA	1	1.010	-	-		QHG53526
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102053
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.670