Protein Alignment smid and Pex1

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_652016.1
• Gene: Pex1 / 45460
• FlyBaseID: FBgn0013563
• Length: 1006
• Species: Drosophila melanogaster
• Alignment Length: 1016
• Identity: 232/1016 - (22%)
• Similarity: 392/1016 - (38%)
• Gaps: 315/1016 - (31%)

  Fly     2 KKAKPLLHDHLITIRVKKYLEEHIGETYLD--VKQMTRELMQKYPEYSRRKF------GPFRQLV 58
            :|..||.|...:: .||..::.:..:.:::  .|.:.||        |.|.|      |.:|:..
  Fly   204 EKLTPLTHSSTVS-NVKNTIQRNKRQDHMERLKKDLRRE--------SSRSFEFRVIRGLWREQA 259

  Fly    59 HQAFSIIS-----ESYNLD---------------KVSSSEEDCVSEDSEPP---PTNSVMNNMMN 100
            .::...::     |.::||               :|.:.|:|.  ||..|.   |:..:..|:|.
  Fly   260 QESDVFVNGKHLPEFFDLDLFYCMHTAADKDYYVRVRTVEDDI--EDDLPETIHPSIELNANLMK 322

  Fly   101 SLYSQPRKPLAPKPISEPIDISSGDENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLM-- 163
            .|..:..:.:..:|.:..::..  ::.|..:|.||..               .:..:|.||.:
  Fly   323 LLGIKELERVVLRPKTTVVNFV--EKIELFANKKTHY---------------KIMENAFKRFVIE 370

  Fly   164 -----------EEV--------------PE---IAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNR 200
                       |||              ||   ..|...:..|.:.|:  :::.::.:.:::
  Fly   371 RTQHKPMLFNQEEVVRLEDDLLVTVGILPEHFRYCVVDAQFLKESKIY--AADLVRPVGEII--- 430

  Fly   201 AKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCE 265
                .|:..|.|      |...|.|.|....|::                     :|..::|| .
  Fly   431 ----KEETPPTS------PLSVQDLIQLPEYDKI---------------------VDQVVQEL-R 463

  Fly   266 MLIHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQL-KMPLMEIPATELIGG--ISGE 327
            |.:.:.:..     .::....:||.|..|.|||.|...|..|| :.|  :....|...|  ..|.
  Fly   464 MNLCLSADN-----SVMRQCNVLLAGASGTGKTVLVERILDQLSRKP--DYCHFEFFHGSRSKGR 521

  Fly   328 SEERI----REVFDQAIGYSPCVLFIDEIDAIG-GNRQWASKDME--RRIVSQLISSLDNLKANE 385
            ..|.|    |.:|...:.::|.::.::.:|.:. ...:.:|:|.|  .|:...:...:.....|
  Fly   522 KTESIQKDLRNIFTSCLQHAPAIVVLENLDVLAHAAGEQSSQDGEYYNRMADTVYQLIVQYTTN- 585

  Fly   386 FGQSVVVIAATTRPDVLDPGLRRI----GRFDHEIAIHIPS--RKERREILRIQCEGLSVDPKLN 444
              .::.|||.......|:   :|:    ||...:....:|:  |.:|..|||..|..::|...|:
  Fly   586 --NAIAVIATVNELQTLN---KRLSSPRGRHVFQTVARLPNLERADREIILRELCSHINVAKDLD 645

  Fly   445 YDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETP 509
            ..|.:.||.||...||:..|.||...|.:   :.|.:.|            |.:|:..|....|.
  Fly   646 LVKFSNLTEGYRKCDLVQFVERAIFYAYR---ISKTQPL------------LTNDQLIESLEHTN 695

  Fly   510 VPDSKG----EETAKDAEA-EQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKK 569
            ....:|    :.|..||:| |.:|:             :.|.:|:.
  Fly   696 SYCLQGIQSNQRTGNDADANEMRVE-------------ELPGLESV------------------- 728

  Fly   570 SAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTL 634
                                                                             
  Fly   729 ----------------------------------------------------------------- 728

  Fly   635 IDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGV 699
                                         :|.||::       ::.|.:||.:.....|...:||
  Fly   729 -----------------------------VGVLEEV-------LMWPSRYPTIFNASPLRNQAGV 757

  Fly   700 LLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEF 764
            ||.||||.|||.|...:|....:..||||||||:..|:|:||..||..|.|||::.|||:|||||
  Fly   758 LLYGPPGTGKTYLVSQLATSWNLRIISVKGPELLAKYIGQSEENVRNLFNRARSARPCVLFFDEF 822

  Fly   765 DSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYV 829
            |||.|||  |.|......|:|||||||:||||..:||.::|||:||:::|||:||.||:|.::..
  Fly   823 DSLAPKR--GHDSTGVTDRVVNQLLTELDGVEGLQGVTVIAATSRPELLDPALLRSGRIDRLVEC 885

  Fly   830 GFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNN-G 893
            ..|:...|..|.:|.:....   |.:.||.|..|.:|..|||||:..::..|:|.:::::|.. |
  Fly   886 PLPDAPARVRIFEALSSTLS---LDECVDFDWFAGKTANYTGADIQSILTSANMAAVKEALAQFG 947

  Fly   894 DTNL-DDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLKY 933
            ...| ..:.::.:|..|:.|..|||::..|...|.:...::
  Fly   948 HEKLAKKISLKQKHLIESFQTTRPSLSASDVAKYHRTYARF 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247	15/81 (19%)
		CDC48	<242..933	CDD:273521	181/713 (25%)
Pex1	NP_652016.1	PEX-1N	93..168	CDD:462729
		CDC48	365..983	CDD:273521	199/820 (24%)
		RecA-like_PEX1_r2	728..885	CDD:410934	81/278 (29%)