DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and spas

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_651206.3	Gene:	spas / 42846	FlyBaseID:	FBgn0039141	Length:	758	Species:	Drosophila melanogaster

Alignment Length:	731	Identity:	175/731 - (23%)
Similarity:	283/731 - (38%)	Gaps:	167/731 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 QNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGLLPSRGLLLHG 291
            ||.|:::.:      .:.||:|..|:..|.:..|....:....|:..|   .....|..|.
  Fly   166 QNSSKEQQQ------SLNHPSELNREGDGQEQQLSNQPQRFRPIQPLE---MAANRPGGGY---- 217

  Fly   292 PPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIG 356
            .||.|...||:                         .:...|..|:    |....|.|||.:.
  Fly   218 SPGPGDPLLAK-------------------------QKHHHRRAFE----YISKALKIDEENE-- 251

  Fly   357 GNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIP 421
            |:::.|.:...:.|             .|....:.|...:.|.||.|    |..|...::..::.
  Fly   252 GHKELAIELYRKGI-------------KELEDGIAVDCWSGRGDVWD----RAQRLHDKMQTNLS 299

  Fly   422 SRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAA 486
            ..::|...|.:                                 |...:.::|.|:|:.::..|.
  Fly   300 MARDRLHFLAL---------------------------------REQDLQMQRLSLKEKQKEEAQ 331

  Fly   487 SEKNMTTVTLDDDEPSEDAGETPVP-----DSKGEETAKDAEAEQKVDGDKET--SAKDKSEGDS 544
            |:...|.      ||.. ||.|..|     .|.|........|:....|.|.|  |.:..:...:
  Fly   332 SKPQKTR------EPML-AGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVA 389

  Fly   545 PNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVD---NVAPEEPKKAVEQEVDSSSS---- 602
            ...:|..:.....:|:.:.|:.|.|:|..|........   |..|:..:..:.....|.|.
  Fly   390 NKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTP 454

  Fly   603 --NDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIG 665
              :.:..|..|.:|                   ::|     ::::..||.|         |.||.
  Fly   455 VVSVKGVEQKLVQL-------------------ILD-----EIVEGGAKVE---------WTDIA 486

  Fly   666 ALEKIREELKLAVLAPVKYPEMLERLGLTAPS-GVLLCGPPGCGKTLLAKAIANEAGINFISVKG 729
            ..:..::.|:..|:.|...||:.  .||.||: |:||.||||.||||||:|:|.|....|:::..
  Fly   487 GQDVAKQALQEMVILPSVRPELF--TGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISA 549

  Fly   730 PELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDG 794
            ..|.:.|||:.|:.|||.|..||:..|.:||.||.|||..:||  ...:.:..|:..:.|.|.||
  Fly   550 ASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERS--SSEHEASRRLKTEFLVEFDG 612

  Fly   795 V---EERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADD 856
            :   .:...:.:|||||||..:|.|.||  |....:||..|::..|..:|....:....|:  |.
  Fly   613 LPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPL--DT 673

  Fly   857 VDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDL----CVRSQHFQEALQQLRPS 917
            ..|..:|..|:||:|:||..|.|.|::..:|: ||.......|:    .:..|.|..:|:::|.|
  Fly   674 EALRRLAKITDGYSGSDLTALAKDAALEPIRE-LNVEQVKCLDISAMRAITEQDFHSSLKRIRRS 737

  Fly   918 VNEQDRKIYDKLRLKY 933
            |..|....|:|....|
  Fly   738 VAPQSLNSYEKWSQDY 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	160/671 (24%)
		AAA	287..418	CDD:278434	23/130 (18%)
		P-loop_NTPase	679..>716	CDD:304359	20/37 (54%)
		AAA	699..830	CDD:278434	55/133 (41%)
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	19/100 (19%)
		P-loop_NTPase	482..>538	CDD:304359	26/57 (46%)
		AAA	515..652	CDD:214640	58/140 (41%)
		AAA	519..650	CDD:278434	56/134 (42%)
		Vps4_C	<722..754	CDD:286426	10/32 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900