Protein Alignment smid and spas

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_651206.3
• Gene: spas / 42846
• FlyBaseID: FBgn0039141
• Length: 758
• Species: Drosophila melanogaster
• Alignment Length: 731
• Identity: 175/731 - (23%)
• Similarity: 283/731 - (38%)
• Gaps: 167/731 - (22%)

  Fly   227 QNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGLLPSRGLLLHG 291
            ||.|:::.:      .:.||:|..|:..|.:..|....:....|:..|   .....|..|.
  Fly   166 QNSSKEQQQ------SLNHPSELNREGDGQEQQLSNQPQRFRPIQPLE---MAANRPGGGY---- 217

  Fly   292 PPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIG 356
            .||.|...||:                         .:...|..|:    |....|.|||.:.
  Fly   218 SPGPGDPLLAK-------------------------QKHHHRRAFE----YISKALKIDEENE-- 251

  Fly   357 GNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIP 421
            |:::.|.:...:.|             .|....:.|...:.|.||.|    |..|...::..::.
  Fly   252 GHKELAIELYRKGI-------------KELEDGIAVDCWSGRGDVWD----RAQRLHDKMQTNLS 299

  Fly   422 SRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAA 486
            ..::|...|.:                                 |...:.::|.|:|:.::..|.
  Fly   300 MARDRLHFLAL---------------------------------REQDLQMQRLSLKEKQKEEAQ 331

  Fly   487 SEKNMTTVTLDDDEPSEDAGETPVP-----DSKGEETAKDAEAEQKVDGDKET--SAKDKSEGDS 544
            |:...|.      ||.. ||.|..|     .|.|........|:....|.|.|  |.:..:...:
  Fly   332 SKPQKTR------EPML-AGMTNEPMKLRVRSSGYGPKATTSAQPTASGRKLTIGSKRPVNLAVA 389

  Fly   545 PNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVD---NVAPEEPKKAVEQEVDSSSS---- 602
            ...:|..:.....:|:.:.|:.|.|:|..|........   |..|:..:..:.....|.|.
  Fly   390 NKSQTLPRNLGSKTSVGAVQRQPAKTAATPPAVRRQFSSGRNTPPQRSRTPINNNGPSGSGASTP 454

  Fly   603 --NDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIG 665
              :.:..|..|.:|                   ::|     ::::..||.|         |.||.
  Fly   455 VVSVKGVEQKLVQL-------------------ILD-----EIVEGGAKVE---------WTDIA 486

  Fly   666 ALEKIREELKLAVLAPVKYPEMLERLGLTAPS-GVLLCGPPGCGKTLLAKAIANEAGINFISVKG 729
            ..:..::.|:..|:.|...||:.  .||.||: |:||.||||.||||||:|:|.|....|:::..
  Fly   487 GQDVAKQALQEMVILPSVRPELF--TGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISA 549

  Fly   730 PELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDG 794
            ..|.:.|||:.|:.|||.|..||:..|.:||.||.|||..:||  ...:.:..|:..:.|.|.||
  Fly   550 ASLTSKYVGDGEKLVRALFAVARHMQPSIIFIDEVDSLLSERS--SSEHEASRRLKTEFLVEFDG 612

  Fly   795 V---EERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADD 856
            :   .:...:.:|||||||..:|.|.||  |....:||..|::..|..:|....:....|:  |.
  Fly   613 LPGNPDGDRIVVLAATNRPQELDEAALR--RFTKRVYVSLPDEQTRELLLNRLLQKQGSPL--DT 673

  Fly   857 VDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDL----CVRSQHFQEALQQLRPS 917
            ..|..:|..|:||:|:||..|.|.|::..:|: ||.......|:    .:..|.|..:|:::|.|
  Fly   674 EALRRLAKITDGYSGSDLTALAKDAALEPIRE-LNVEQVKCLDISAMRAITEQDFHSSLKRIRRS 737

  Fly   918 VNEQDRKIYDKLRLKY 933
            |..|....|:|....|
  Fly   738 VAPQSLNSYEKWSQDY 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247
		CDC48	<242..933	CDD:273521	171/714 (24%)
spas	NP_651206.3	MIT_spastin	230..308	CDD:239142	19/100 (19%)
		RecA-like_spastin	484..648	CDD:410932	66/169 (39%)
		AAA_lid_3	676..727	CDD:465537	16/51 (31%)
		Vps4_C	<722..754	CDD:462762	10/32 (31%)