DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and Nsf2

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	149/543 - (27%)
Similarity:	232/543 - (42%)	Gaps:	168/543 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 LSVDPKLNY----DKIA--ELTPGYVGADLMALVSRA-ASVAVKRR-SMKKFR------------ 481
            :|..|.|:|    :||:  ||..|:||   .:||.|. |::::.:. .::.:|
  Fly    41 ISPGPGLHYIFALEKISGPELPLGHVG---FSLVQRKWATLSINQEIDVRPYRFDASADIITLVS 102

  Fly   482 -ELHAASEKNMTTVTLDDDEPSED-----------AGETPVPDSKGEE----TAKDAEAEQKVDG 530
             |.....:|..|....|.||.:::           .|:|.|...|.::    ..|..||   ||
  Fly   103 FETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLTVGQTLVFQFKDKKFLGLAVKTLEA---VD- 163

  Fly   531 DKETSAKDKSEGDSPNIETPKKAT------NGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEP 589
                   .::.|||    .||...      .||:.::         .||..::.:   |:.....
  Fly   164 -------PRTVGDS----LPKTRNVRFGRILGNTVVQ---------FEKAENSVL---NLQGRSK 205

  Fly   590 KKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFI 654
            .|.|.|.:.:
  Fly   206 GKIVRQSIIN------------------------------------------------------- 215

  Fly   655 TVPDTTWD----DIGALEK-IREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAK 714
              ||  ||    .||.|:| .....:.|..:.|..||::|:||:....|:||.||||.||||:|:
  Fly   216 --PD--WDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMAR 276

  Fly   715 AI-----ANEAGINFISVKGPELMNMYVGESERAVRACFQRAR--------NSAPCVIFFDEFDS 766
            .|     |.|..|    |.||::::.||||||..:|..|..|.        ||...:|.|||.|:
  Fly   277 QIGTMLNAREPKI----VNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDA 337

  Fly   767 LCPKRSDGGDGNNSGTR--IVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYV 829
            :|..|  |....|||..  :|||||.::||||:...:.::..|||.|:||.|:||||||:..:.:
  Fly   338 ICKAR--GSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEI 400

  Fly   830 GFPEQSERTEILKATTKNGKR-PVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLN-N 892
            ..|.:..|.:||...||..:. ..:|.|||.:||||:|:.::||:|.|||:.|...::.:.:. :
  Fly   401 SLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRLIKAD 465

  Fly   893 GDTNLDDLCVRSQHFQEALQQLR 915
            ...::|         .||:::||
  Fly   466 SKVHVD---------PEAMEKLR 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	149/543 (27%)
		AAA	287..418	CDD:278434
		P-loop_NTPase	679..>716	CDD:304359	18/36 (50%)
		AAA	699..830	CDD:278434	62/145 (43%)
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012	15/50 (30%)
		CDC48_2	117..>170	CDD:215011	13/63 (21%)
		AAA	259..404	CDD:214640	63/150 (42%)
		AAA	261..402	CDD:278434	62/146 (42%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810