DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and CG16789

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_649910.3	Gene:	CG16789 / 41154	FlyBaseID:	FBgn0037712	Length:	831	Species:	Drosophila melanogaster

Alignment Length:	892	Identity:	170/892 - (19%)
Similarity:	297/892 - (33%)	Gaps:	245/892 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 ENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGS---------ALKRLMEEVPEIAVAAKKVAKPNT 181
            :::|...|..|....|.:.||.......:|.|         .|...:|:|.:           |.
  Fly    28 QHQDVETTVATMNAAVGSVAADADAKALLQSSLYEFYLRYICLSNRLEDVYD-----------NM 81

  Fly   182 IHVSSSEAIQKLHQVVGNRAKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHP 246
            |.....:.::||......|...|..|.|       |: .|.:..:.::..:|||....:.|::.|
  Fly    82 IQPQKRQLVRKLLDACLGRVVELKHDLV-------NI-DLMEFSYNDEVVERLRLTPMETELRIP 138

  Fly   247 ----TESFRDIGGMDSTLKELCEMLIHIKSPEF--YFQLGLLPSRGLLLHGPPGCGKTFLARAIS 305
                .|..:::.....|:.|:...|..::..|.  .....:...|.|.:|          .||..
  Fly   139 RYFLRERQQELEFRKKTMHEILTKLGWLEEHELEETVTTEIEAIRMLQMH----------ERARQ 193

  Fly   306 GQLKMPLMEIPATEL-IGGISGESEERI-REVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMER 368
            |:|:...|:    |: |....|:||||. :|..|..:           :.|:...:.|.. ...|
  Fly   194 GRLRAHFMK----EIRILKEKGKSEERTEKERSDSGL-----------LAAMKIQKMWRG-HTAR 242

  Fly   369 RIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQ 433
            ||.          :..:..:.:::......|.|:                     |||.|.|.
  Fly   243 RIT----------RRRKMEEMILIGMLPPPPAVV---------------------KERAEKLE-- 274

  Fly   434 CEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMK-KFRELHAASEK----NMTT 493
                    ||.:::.......:.|.:.          ..::.::| :.|..|.||.|    :...
  Fly   275 --------KLQHNEKRYQAQAFYGKEF----------EERQNALKEEIRAKHGASMKEDIADEIR 321

  Fly   494 VTLDD---------DEPSEDAGET----PVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSP 545
            ..:.|         |.||||.|.:    ..|.::.|.:...|.:.::       |.|.|.:..||
  Fly   322 AWVKDCYDKTGKLPDFPSEDQGGSLHIFSRPGTESEHSRSSARSSKE-------SRKTKDKSKSP 379

  Fly   546 NIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDV--------DNVAPEEPKKAVEQEV-DSSS 601
                   |.:|:.::...|.........|:....|:        |....::....:.|.. :...
  Fly   380 -------ARSGDLNVNENQDEEVSFQPAPSVCLPDIRAEIDLFNDTWRDKDETGVLSQAAYEDMI 437

  Fly   602 SNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPS-----------AKREGFIT 655
            .:|:|.|..| |....:|:...:.      :.|:......||.:.|           .|:|..:|
  Fly   438 YSDKYQEVEL-EFRRAVDDVMRQE------IELLQTAVGKKVKKSSKKTRRSGKKSKKKKEKDLT 495

  Fly   656 VPDTTWDDIGALEKIREELKLAVLAPVKYPE-----------MLERLGLTAPS------------ 697
             ||.|      .|.:.|||....:.. ||||           :..|:| |.||
  Fly   496 -PDRT------TESLYEELVTNGIIR-KYPELRLKQFLGDKALTARIG-TNPSPGDIRQILTEYC 551

  Fly   698 -----------------GVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESE--RA 743
                             .:||.||.|.||..|..||..|.|.....:....::..|.|:|.  ..
  Fly   552 ILPLGSDAIHNCTPLIRSILLAGPKGSGKKALLHAICTEVGAVLFDLTPANIVGKYPGKSGLIML 616

  Fly   744 VRACFQRARNSAPCVIFFDE----FDSLCPK--RSDGGDGNNSGTRIVNQLLTEMDGVEERKGVY 802
            :....:.:|...|.|||..:    |....||  |:|       ..|:...|...:..:.....|.
  Fly   617 IHLVLKVSRLLQPAVIFMGDAERPFMKKIPKTDRTD-------PKRLKKDLPKLIKNIAPEDRVV 674

  Fly   803 ILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTE 867
            .:..:|.|...|..:|: ...:..:|:..|:....:...|....:....:  .::|...:|..::
  Fly   675 FIGTSNLPWEADQKLLQ-SVYNRFIYIPRPDYGAMSHAWKTLLHDYSGGI--SNLDTSAMAKISD 736

  Fly   868 GYTGADLAGLVKQA----SMFSLR-QSLNNGDTNLDDLCVRSQHFQE 909
            |||...:...:|:.    ....|| |.|.|.:. ::.||.|...::|
  Fly   737 GYTIGSIDACLKEVMTCKRKLQLRTQPLTNAEL-INVLCSRDPVYRE 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	140/734 (19%)
		AAA	287..418	CDD:278434	23/132 (17%)
		P-loop_NTPase	679..>716	CDD:304359	17/76 (22%)
		AAA	699..830	CDD:278434	33/138 (24%)
CG16789	NP_649910.3	AAA	568..704	CDD:214640	33/143 (23%)
CG16789	NP_649910.3	AAA	570..702	CDD:278434	33/139 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810