DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and nvl

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_998649.1	Gene:	nvl / 406805	ZFINID:	ZDB-GENE-040426-2871	Length:	796	Species:	Danio rerio

Alignment Length:	952	Identity:	373/952 - (39%)
Similarity:	511/952 - (53%)	Gaps:	213/952 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RVKKYLEEHIGETYLDVKQMTRELMQKYP-EYSRRKFGPFRQLVHQAFSIISESYNLDKVSSSEE 79
            ||.:||:.. .:.|:||..|..||.|::. ||.||....||..|.:.|::|
Zfish    16 RVHQYLKTR-NDQYVDVSAMASELQQQFRIEYGRRNRTAFRIQVEKVFALI-------------- 65

  Fly    80 DCVSEDSEPPPTNSVMNNMMNSLYSQPRKPLAPKPISEPID-------ISSGDENEDDSNTKTTN 137
             |...|||    .|.:.|          |.||.:....|.|       .||.|..:|....:.||
Zfish    66 -CSESDSE----FSALEN----------KHLAKRARRSPEDGDGSHVTASSTDSEDDIPEHEHTN 115

  Fly   138 GDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSE--AIQKLHQVVGNR 200
            .                ..|:|..|.:.      .|...:..:||..|.|:  .|.|    .|:|
Zfish   116 H----------------MNSSLTSLYQR------GAANASSSSTIQRSLSDDWIIDK----TGDR 154

  Fly   201 AK-----NLSEDAVPRSKDHRNVPGLYQQLHQ-NQSRDRLRKFKRD----------------LEV 243
            .:     :|.|:....:.:.|:...|.::... .|.|.:..|.:.|                .|:
Zfish   155 GQESILIDLCEEESSSTTNQRDSSRLEKEKKSVKQKRQKKNKLEEDSETSAGVPAKKSKVKGFEL 219

  Fly   244 QHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQL 308
            |..:..|.|.||.|.||:|:|::|||::.||.|.:||::|.||.|||||||||||.||:|::|:.
Zfish   220 QFSSVKFEDFGGSDETLEEVCKLLIHMRHPEVYQRLGVVPPRGFLLHGPPGCGKTLLAQAVAGET 284

  Fly   309 KMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQ 373
            .:||::|.|.||:.|:|||||:::||:|:|||..:||:|||||||||...|:.||||||||||:|
Zfish   285 ALPLLKISAPELVSGVSGESEQKLRELFEQAISSAPCILFIDEIDAITPKRETASKDMERRIVAQ 349

  Fly   374 LISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLS 438
            |::.:|:|.:......|:||.||.|||.|||.|||.||||.||.:.||....|.:||:..|..:.
Zfish   350 LLTCMDDLNSMLEPAQVLVIGATNRPDSLDPALRRAGRFDREICLGIPDEGARMKILKTLCRKIR 414

  Fly   439 VDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSE 503
            :....::..:|.|||||||||||||...||..||.|..:                      ||:.
Zfish   415 LPDDFDFRHLARLTPGYVGADLMALCREAAMNAVNRILL----------------------EPTT 457

  Fly   504 DAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPK 568
            :
Zfish   458 E---------------------------------------------------------------- 458

  Fly   569 KSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLT 633
                         |.:.   |..|:.:.:|...|:....|..||.|                |:.
Zfish   459 -------------DQIT---PTLALARLLDLLKSSVSLSEDQLAAL----------------CVL 491

  Fly   634 LIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSG 698
            :.||..::..:|||||||||.||||.||.|:|||:.:||||.:|::||::.||..:.|||:||:|
Zfish   492 MSDFSSSLVRVQPSAKREGFATVPDVTWADVGALQDVREELHMAIMAPIQNPEQFKALGLSAPAG 556

  Fly   699 VLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDE 763
            :||.|||||||||||||:||.:|:||||||||||:||||||||||||..|||.||||||||||||
Zfish   557 LLLAGPPGCGKTLLAKAVANASGLNFISVKGPELLNMYVGESERAVRQVFQRGRNSAPCVIFFDE 621

  Fly   764 FDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILY 828
            .|:|||:||:...|  :..|:||||||||||:|.|:.|:|:||||||||||||:|||||||..||
Zfish   622 IDALCPRRSEHESG--ASVRVVNQLLTEMDGMENRRQVFIMAATNRPDIIDPAVLRPGRLDKTLY 684

  Fly   829 VGFPEQSERTEILKATTKNGKRPVLADDVDLDEIA--AQTEGYTGADLAGLVKQASMFSLRQSLN 891
            ||.|..::|..||...||.|.:|.|..||.|:|||  |:.|.:|||||:.||::|.:.:||..|:
Zfish   685 VGLPPAADRHAILNTITKGGTKPQLDSDVSLEEIAHDARCETFTGADLSALVREACVNALRVHLD 749

  Fly   892 NGDTNLD---DLCVRSQHFQEALQQLRPSVNEQDRKIYDKLR 930
            ...|:.:   |:.|...||::|.:::||||:::|:.:|::||
Zfish   750 PAQTHTESAKDIRVSRVHFEDAFKKVRPSVSKKDQLMYERLR 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	20/55 (36%)
		SpoVK	271..919	CDD:223540	297/652 (46%)
		AAA	287..418	CDD:278434	79/130 (61%)
		P-loop_NTPase	679..>716	CDD:304359	24/36 (67%)
		AAA	699..830	CDD:278434	98/130 (75%)
nvl	NP_998649.1	Nucleolin_bd	2..71	CDD:293330	21/70 (30%)
		RNA_polI_A34	<165..215	CDD:285426	7/49 (14%)
		SpoVK	246..792	CDD:223540	302/666 (45%)
		AAA	264..395	CDD:278434	79/130 (61%)
		P-loop_NTPase	537..>573	CDD:304359	23/35 (66%)
		AAA	557..687	CDD:278434	99/131 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594096
Domainoid	1	1.000	210	1.000	Domainoid score	I2776
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1902
Inparanoid	1	1.050	634	1.000	Inparanoid score	I809
OMA	1	1.010	-	-		QHG53526
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102053
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1718
SonicParanoid	1	1.000	-	-		X2802
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800