Protein Alignment smid and DRC11L

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_001291348.1
• Gene: DRC11L / 392843
• HGNCID: 22831
• Length: 818
• Species: Homo sapiens
• Alignment Length: 840
• Identity: 170/840 - (20%)
• Similarity: 298/840 - (35%)
• Gaps: 238/840 - (28%)

  Fly   216 RNVPGLYQQLHQNQSRDRLRKF-----KRDLEVQHPTESFRDIGGMDSTLK-ELCE------ML- 267
            |....:|.|:.|.|.|..||:.     .|.||::            |..:: :|||      :|
Human    55 RRFDTVYDQMVQPQKRRLLRRLLDGVAGRVLELK------------DELVRADLCENHCLDRVLQ 107

  Fly   268 --------IHIKSPEFYF--QLGLLPSRGLLLH------GPPGCGKTFLA--------------R 302
                    :.:..|:::.  |...:..|||:|.      .|....|:|..              |
Human   108 DFKLTPADLEVPIPKYFLLEQSTTVRERGLILAEILSRLEPVSSQKSFTGMHRTEAIILVQKAER 172

  Fly   303 AISGQLKMPLM-EIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDM 366
            |..|:|:...| ||...|       |.:.||||............:.|.::  ..|..|......
Human   173 ARQGRLRATFMREIRRDE-------EQDGRIREDGWHKFSQGQAAVTIQKV--WKGYLQRKRTQQ 228

  Fly   367 ERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHE--------------IA 417
            :||:..:.|..|.:      ...|..::..::|.::: .::|:.:.:.|              :.
Human   229 DRRMEMEFIGMLPS------PNQVEHLSIISQPCLVE-DVQRLRQMEKEEEFRAAMVKAHDSLVE 286

  Fly   418 IHIPSRKER-REILR---IQCEGLS--------VDPKLNYDKIAELTPGYVGADLMALV------ 464
            ...|..||: :|.:|   |:|..|:        .....:|...|:.||..|..:|...:
Human   287 TEGPDMKEKMKEQIRQWFIECHDLTGRFPDYPDASSGGSYSIFADKTPEQVRMELEMQMQENRKK 351

  Fly   465 --SRAASVAVKRRSMKKFRE-----------LHAASEKNMTTVTLDDDE-------------PSE 503
              .::.......:..||.:|           |.....|.:..:....:|             ||:
Human   352 EQEKSKEKGKDEKEKKKGKEEKAKKGEVDAVLQVLPSKCIPMICAGHEEYLNTWKNRCESIHPSQ 416

  Fly   504 DAGETPVPDSKGEETAKDAEAEQKVDGD--------KETSAKDKSEGDSPNIETPKKATNGNSSI 560
            :...    ::..||..|:.|.|.::..|        |...|.||.|      |.|         :
Human   417 NYDS----ETLREEKRKEVELEIRIQVDELMRQELRKLRLAVDKEE------ERP---------L 462

  Fly   561 KSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTL----------AELT 615
            ::|:|||.|...|                ||  |:::.|..|.:..||..:          ..|.
Human   463 RAPKKTPGKKTGK----------------KK--EKDLTSDRSVESLYEELVISGLLRKSESVALK 509

  Fly   616 NFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLA 680
            :::.    :|......|:|:.     |:..||                   |..||:.:.|..:.
Human   510 DYIG----DFLYLGSTLSLVK-----KLPMPS-------------------LFDIRQNVALYAVL 546

  Fly   681 PVKYPEMLERLGLTAP--SGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGE--SE 741
            .:..|:    :.:.||  ..:||.||.|.||.:|.||:..|.|.|...:....|:..|.|.  ::
Human   547 RLGSPD----IHIMAPLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQ 607

  Fly   742 RAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAA 806
            ..|...|:.||...|.||:....:....|::...|......||...|...:..:.....|.::..
Human   608 MMVHIVFKVARLLQPSVIWIGNAEKNFYKKTPKEDKEMDPKRIKKDLTKALRLLTPGDRVMLIGT 672

  Fly   807 TNRPDIID-PAILRPGRLDTILYVGFPEQSERTEILKATTK-NGKRPVLADDVDLDEIAAQTEGY 869
            |:||.:.: ..:.|.  .:.||::..|:.:.|..:.|...: .|.:|  ...:|:..:|..::||
Human   673 TSRPQLAEMRGLCRV--YERILFMPRPDYASRYVLWKRMIEARGIQP--TQHLDISALAKVSDGY 733

  Fly   870 TGADLAGLVKQA--SMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKIYD 927
            |    .|.:.||  |:.|.|:.|     .|....:.:..|...|.:|.|...|::..:.|
Human   734 T----PGHILQAIQSVLSERRFL-----QLSKRPLVASEFLGQLVKLDPVYREEEESLKD 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247
		CDC48	<242..933	CDD:273521	160/809 (20%)
DRC11L	NP_001291348.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..377		3/32 (9%)
		SpoVK	411..744	CDD:440232	90/409 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	458..482		12/56 (21%)
		P-loop containing Nucleoside Triphosphate Hydrolases	535..694	CDD:476819	41/164 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	795..818