DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and IQCA1L

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001291348.1	Gene:	IQCA1L / 392843	HGNCID:	22831	Length:	818	Species:	Homo sapiens

Alignment Length:	840	Identity:	170/840 - (20%)
Similarity:	298/840 - (35%)	Gaps:	238/840 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 RNVPGLYQQLHQNQSRDRLRKF-----KRDLEVQHPTESFRDIGGMDSTLK-ELCE------ML- 267
            |....:|.|:.|.|.|..||:.     .|.||::            |..:: :|||      :|
Human    55 RRFDTVYDQMVQPQKRRLLRRLLDGVAGRVLELK------------DELVRADLCENHCLDRVLQ 107

  Fly   268 --------IHIKSPEFYF--QLGLLPSRGLLLH------GPPGCGKTFLA--------------R 302
                    :.:..|:::.  |...:..|||:|.      .|....|:|..              |
Human   108 DFKLTPADLEVPIPKYFLLEQSTTVRERGLILAEILSRLEPVSSQKSFTGMHRTEAIILVQKAER 172

  Fly   303 AISGQLKMPLM-EIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDM 366
            |..|:|:...| ||...|       |.:.||||............:.|.::  ..|..|......
Human   173 ARQGRLRATFMREIRRDE-------EQDGRIREDGWHKFSQGQAAVTIQKV--WKGYLQRKRTQQ 228

  Fly   367 ERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHE--------------IA 417
            :||:..:.|..|.:      ...|..::..::|.::: .::|:.:.:.|              :.
Human   229 DRRMEMEFIGMLPS------PNQVEHLSIISQPCLVE-DVQRLRQMEKEEEFRAAMVKAHDSLVE 286

  Fly   418 IHIPSRKER-REILR---IQCEGLS--------VDPKLNYDKIAELTPGYVGADLMALV------ 464
            ...|..||: :|.:|   |:|..|:        .....:|...|:.||..|..:|...:
Human   287 TEGPDMKEKMKEQIRQWFIECHDLTGRFPDYPDASSGGSYSIFADKTPEQVRMELEMQMQENRKK 351

  Fly   465 --SRAASVAVKRRSMKKFRE-----------LHAASEKNMTTVTLDDDE-------------PSE 503
              .::.......:..||.:|           |.....|.:..:....:|             ||:
Human   352 EQEKSKEKGKDEKEKKKGKEEKAKKGEVDAVLQVLPSKCIPMICAGHEEYLNTWKNRCESIHPSQ 416

  Fly   504 DAGETPVPDSKGEETAKDAEAEQKVDGD--------KETSAKDKSEGDSPNIETPKKATNGNSSI 560
            :...    ::..||..|:.|.|.::..|        |...|.||.|      |.|         :
Human   417 NYDS----ETLREEKRKEVELEIRIQVDELMRQELRKLRLAVDKEE------ERP---------L 462

  Fly   561 KSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTL----------AELT 615
            ::|:|||.|...|                ||  |:::.|..|.:..||..:          ..|.
Human   463 RAPKKTPGKKTGK----------------KK--EKDLTSDRSVESLYEELVISGLLRKSESVALK 509

  Fly   616 NFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLA 680
            :::.    :|......|:|:.     |:..||                   |..||:.:.|..:.
Human   510 DYIG----DFLYLGSTLSLVK-----KLPMPS-------------------LFDIRQNVALYAVL 546

  Fly   681 PVKYPEMLERLGLTAP--SGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGE--SE 741
            .:..|:    :.:.||  ..:||.||.|.||.:|.||:..|.|.|...:....|:..|.|.  ::
Human   547 RLGSPD----IHIMAPLIRSILLVGPSGMGKKMLVKAVCTETGANLFDLSPENLLGKYPGRNGAQ 607

  Fly   742 RAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAA 806
            ..|...|:.||...|.||:....:....|::...|......||...|...:..:.....|.::..
Human   608 MMVHIVFKVARLLQPSVIWIGNAEKNFYKKTPKEDKEMDPKRIKKDLTKALRLLTPGDRVMLIGT 672

  Fly   807 TNRPDIID-PAILRPGRLDTILYVGFPEQSERTEILKATTK-NGKRPVLADDVDLDEIAAQTEGY 869
            |:||.:.: ..:.|.  .:.||::..|:.:.|..:.|...: .|.:|  ...:|:..:|..::||
Human   673 TSRPQLAEMRGLCRV--YERILFMPRPDYASRYVLWKRMIEARGIQP--TQHLDISALAKVSDGY 733

  Fly   870 TGADLAGLVKQA--SMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKIYD 927
            |    .|.:.||  |:.|.|:.|     .|....:.:..|...|.:|.|...|::..:.|
Human   734 T----PGHILQAIQSVLSERRFL-----QLSKRPLVASEFLGQLVKLDPVYREEEESLKD 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	152/754 (20%)
		AAA	287..418	CDD:278434	29/165 (18%)
		P-loop_NTPase	679..>716	CDD:304359	12/38 (32%)
		AAA	699..830	CDD:278434	35/133 (26%)
IQCA1L	NP_001291348.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..377		3/32 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..482		12/56 (21%)
		SpoVK	<561..734	CDD:223540	43/176 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810