DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and CG12010

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_728878.1	Gene:	CG12010 / 38421	FlyBaseID:	FBgn0035443	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	770	Identity:	194/770 - (25%)
Similarity:	310/770 - (40%)	Gaps:	240/770 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 RDRLRKFKRDLE------VQH---------PTESFRDIGGMDSTLKEL---CEML---IHIKSP- 273
            :|.:|.|.|.|:      |||         ..|.|...|..|....|:   .|:|   |.:..|
  Fly   120 KDDVRIFLRHLKLTKGCSVQHRRLVQLGIASVEIFDAPGVADDECFEIAHDAELLLADIRLGMPF 184

  Fly   274 --EFYF------------QLGLL------------PSRGLLLHGPPGCGKTFLARAISGQLKMPL 312
              :|.|            ||..|            |:..|:: ||..|||:.|......:.....
  Fly   185 SLDFIFKYLPHSFERPMEQLEKLLETSKISFSHRFPTTALVV-GPVDCGKSGLLSEFLRRHSCNC 248

  Fly   313 MEIPATELIGGISGESEERIREVFDQAIGYS-------PCVLFIDEIDAIGGNRQWA---SKDME 367
            ..|.|::::....||:||.:|.:|..|..:.       |.|:.|::::.:..:...|   :....
  Fly   249 FYITASQVLRSYPGETEEELRRIFQAAQTFKEKLRPLLPIVILIEDLELLCPSTAVADAKNSSNS 313

  Fly   368 RRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRI 432
            .||.::|...||.|.     :.::.:|.:..||.|....||  ||..|:.|::||..:||:::..
  Fly   314 LRISAELYKLLDALP-----RGIICLATSGVPDSLHEHARR--RFVREVTINMPSEGQRRQLVEH 371

  Fly   433 QCE--GLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVT 495
            .||  .|::...| .:.||..|.|||.|||..|:.|.                      ....:|
  Fly   372 LCEVHELNISQTL-LEHIARNTQGYVIADLTLLLRRV----------------------QQQLLT 413

  Fly   496 LDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSI 560
            .||
  Fly   414 KDD-------------------------------------------------------------- 416

  Fly   561 KSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEF 625
                              .|::::
  Fly   417 ------------------FDIEHI----------------------------------------- 422

  Fly   626 ADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTT--WDDIGALEKIREELKLAVLAPVKYPEML 688
                       |:.::...||||.|...:.|...|  ::.||.:|.::..|:::|||.::.....
  Fly   423 -----------FLKSLSQTQPSASRSTDVRVSKMTAGFEVIGGMEALKRTLQVSVLAGIRQSAAF 476

  Fly   689 ERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARN 753
            .|.||:.|.||||.|||||.||.:||.:|.||.:.||:....|:.:.|||.:||.:...|..||.
  Fly   477 ARFGLSLPKGVLLYGPPGCAKTTVAKCLAKEADMTFIATSAAEVYSPYVGCAERFISRIFDTARK 541

  Fly   754 SAPCVIFFDEFDSLCPKR--SDGGDGNNSGTRIVNQLLTEMDGV---EERKGVYILAATNRPDII 813
            :|||:||.||.|||..:|  |.||.|.....||::.|||||:|:   ..::.:.::|||||||:|
  Fly   542 NAPCLIFLDEIDSLVGRRTVSSGGGGGQVQLRILSTLLTEMNGIVGGGSQQHILVVAATNRPDMI 606

  Fly   814 DPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLV 878
            |.|:|||||.|.:::|..|::..|..:||.   :.:|....::|.|.||||:|:.|:||||..|.
  Fly   607 DDALLRPGRFDKLIHVPAPDEKSRLALLKL---HSQRMPFHENVFLQEIAARTDRYSGADLCNLC 668

  Fly   879 KQASMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLKY 933
            .:|::.:.::.....:..|.|       |::.|.:.:.|:.:.....|.|...::
  Fly   669 NEAAIEAFQRDFKATEIELQD-------FEKVLTKQKSSLTQSQIDGYYKFAYRF 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	176/693 (25%)
		AAA	287..418	CDD:278434	35/140 (25%)
		P-loop_NTPase	679..>716	CDD:304359	19/36 (53%)
		AAA	699..830	CDD:278434	65/135 (48%)
CG12010	NP_728878.1	SpoVK	201..707	CDD:223540	173/678 (26%)
		AAA	224..357	CDD:278434	35/140 (25%)
		AAA	487..623	CDD:278434	65/135 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445203
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23077
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850