DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and Spast

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_008762708.1	Gene:	Spast / 362700	RGDID:	1308494	Length:	614	Species:	Rattus norvegicus

Alignment Length:	647	Identity:	171/647 - (26%)
Similarity:	255/647 - (39%)	Gaps:	152/647 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 ARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQ---WA 362
            |:..||....|..  |:|...|  .|...|.:|....||..|....|.|||.:..|...|   |.
  Rat    87 AKRSSGTAPAPAS--PSTPAPG--PGGEAESVRVFHKQAFEYISIALRIDEEEKAGQKEQAVEWY 147

  Fly   363 SKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERR 427
            .|.:|..               |.|.:|:|.....:       ..|..|...::..::...|:|.
  Rat   148 KKGIEEL---------------EKGIAVIVTGQGEQ-------YERARRLQAKMMTNLVMAKDRL 190

  Fly   428 EILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMT 492
            ::|.      .:.|.|.:.|  ..|..|                                 ...|
  Rat   191 QLLE------KLQPVLQFSK--SQTDVY---------------------------------NEST 214

  Fly   493 TVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGN 557
            .:|..:.....::|  .||..|...|    .|...:...| |..|..|.|.|.:...|  :.:|.
  Rat   215 NLTCRNGHLQSESG--AVPKKKDPLT----HASNSLPRSK-TVMKSGSTGLSGHHRAP--SCSGL 270

  Fly   558 SSI------KSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTN 616
            |.:      ..|..|..|...||....      .|..|..||.::.|               |.|
  Rat   271 SMVSGARPGSGPAATTHKGTSKPNRTN------KPSTPTTAVRKKKD---------------LKN 314

  Fly   617 FLDNPPEEFADPNFC-LTLIDFVD---AIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLA 677
            |.:      .|.|.. |.:.:.||   |:|                  :|||...|..::.|:..
  Rat   315 FRN------VDSNLANLIMNEIVDNGTAVK------------------FDDIAGQELAKQALQEI 355

  Fly   678 VLAPVKYPEMLERLGLTAPS-GVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESE 741
            |:.|...||:.  .||.||: |:||.||||.|||:||||:|.|:...|.::....|.:.||||.|
  Rat   356 VILPSLRPELF--TGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 418

  Fly   742 RAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEER--KGVYIL 804
            :.|||.|..||...|.:||.||.|||..:|.:|  .:::..|:..:.|.|.|||:..  ..|.::
  Rat   419 KLVRALFAVARELQPSIIFIDEVDSLLCERREG--EHDASRRLKTEFLIEFDGVQSAGDDRVLVM 481

  Fly   805 AATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGY 869
            .|||||..:|.|:||  |....:||..|.:..|..:||........|:  ...:|.::|..|:||
  Rat   482 GATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLLLKNLLCKQGSPL--TQKELAQLARMTDGY 542

  Fly   870 TGADLAGLVKQASMFSLR-----QSLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKIY 926
            :|:||..|.|.|::..:|     |..|...:.:.:  :|...|.|:|::::.||:.|..:.|
  Rat   543 SGSDLTALAKDAALGPIRELKPEQVKNMSASEMRN--IRLSDFTESLKKIKRSVSPQTLEAY 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	168/638 (26%)
		AAA	287..418	CDD:278434	28/119 (24%)
		P-loop_NTPase	679..>716	CDD:304359	20/37 (54%)
		AAA	699..830	CDD:278434	56/132 (42%)
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142	21/100 (21%)
		P-loop_NTPase	339..>395	CDD:304359	27/57 (47%)
		AAA	372..508	CDD:214640	59/139 (42%)
		AAA	376..506	CDD:278434	57/133 (43%)
		Vps4_C	<578..610	CDD:286426	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810