DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and Spata5

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_008759154.1	Gene:	Spata5 / 361935	RGDID:	1310478	Length:	893	Species:	Rattus norvegicus

Alignment Length:	870	Identity:	275/870 - (31%)
Similarity:	418/870 - (48%)	Gaps:	201/870 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SSSEED---CVSEDSEPPPTNSVMNNMMNSL-YSQPRKPLAPKPISEPIDISSGDENEDDSNTKT 135
            |||..|   ..||.|....::..::..::.| ..:|:.|.:.....:||            |.:|
  Rat   207 SSSGTDVHGMASEQSSMESSDVDISFQLSQLDLKEPQSPASQSTPCKPI------------NDRT 259

  Fly   136 TNGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNR 200
            .|..|.........|.   .||.|.  :||:..:..:.....:.||..:|.    :||.:.....
  Rat   260 MNKAGEVLLDVTQSPR---DGSGLG--LEEITGLKCSFDSSKEGNTQPISE----EKLLKSTSAG 315

  Fly   201 AKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKF---KRDLEVQHPTESFRDIGGMDSTLKE 262
            |||             |....|  ...:.:|..|||.   .::.:.|... ::..|||::|.||.
  Rat   316 AKN-------------NTDTFY--FISSTTRINLRKICTNSKEQDSQFKV-TYDMIGGLNSQLKA 364

  Fly   263 LCEML-IHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISG 326
            :.|:: :.:|.||.:...|:...|||||:||||.|||.:|||::.::...:..|...|:|....|
  Rat   365 IREIIELPLKQPELFKSYGIPAPRGLLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429

  Fly   327 ESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVV 391
            |:|.|:|::|.:|....|.::||||:||:...|:.|..::|:|:|:.|::.:|.:.:......|:
  Rat   430 ETEARLRQIFAEATLRHPSIIFIDELDALCPKREGAQSEVEKRVVASLLTLMDGIGSEGSEGRVL 494

  Fly   392 VIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDP----KLNYDKIAELT 452
            |:.||.||..||..|||.||||.||.|.||:.::|.:||:   :.|...|    |....::|...
  Rat   495 VLGATNRPQALDAALRRPGRFDKEIEIGIPNAQDRLDILQ---KLLRRVPHLLTKAELLRLANNA 556

  Fly   453 PGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEE 517
            .|||||||.||.:.|...|: ||.::|                    :|:       :||||...
  Rat   557 HGYVGADLKALCNEAGLYAL-RRVLRK--------------------QPN-------LPDSKVAG 593

  Fly   518 TAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVD 582
            ..|
  Rat   594 MVK-------------------------------------------------------------- 596

  Fly   583 NVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPS 647
                                                             :||.||:..:..::||
  Rat   597 -------------------------------------------------ITLNDFLQGMNDIRPS 612

  Fly   648 AKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLL 712
            |.||..|.||:.:|.|||.||.|:.:||.||..|:|:|:...|:|:..|.||||.|||||.||::
  Rat   613 AMREVAIDVPNVSWSDIGGLENIKLKLKQAVEWPLKHPKSFSRMGIQPPKGVLLYGPPGCSKTMI 677

  Fly   713 AKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDG 777
            |||:|||:|:||:::|||||||.||||||||||..|::||..||.:|||||.|:|..:|......
  Rat   678 AKALANESGLNFLAIKGPELMNKYVGESERAVREVFRKARAVAPSIIFFDELDALAVERGSSSGA 742

  Fly   778 NNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILK 842
            .|...|::.||||||||:|:.|.|.:||||||||.||.|::||||:|.|:||..|:.:.|.|||.
  Rat   743 GNVADRVLAQLLTEMDGIEQLKNVTVLAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREILN 807

  Fly   843 ATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLCVRSQHF 907
            ....:  .|: :::|||||:..||:.|:||::..:.|:|::.:|.:       |:...|:..:||
  Rat   808 LQFHS--MPI-SNEVDLDELVLQTDTYSGAEIIAVCKEAALLALEE-------NIKADCIMKRHF 862

  Fly   908 QEALQQLRPSVNEQDRKIYDKLRLK 932
            .:||..:.|.:.|..|:.|:..:.|
  Rat   863 TQALSIVTPRIPESLRRFYEDYQEK 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	227/651 (35%)
		AAA	287..418	CDD:278434	54/130 (42%)
		P-loop_NTPase	679..>716	CDD:304359	19/36 (53%)
		AAA	699..830	CDD:278434	80/130 (62%)
Spata5	XP_008759154.1	CDC48_N	64..132	CDD:304500
		SpoVK	370..882	CDD:223540	229/663 (35%)
		AAA	390..522	CDD:278434	54/131 (41%)
		AAA	664..796	CDD:278434	81/131 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820