DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and TER94

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	926	Identity:	288/926 - (31%)
Similarity:	429/926 - (46%)	Gaps:	250/926 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 NMMNSLYSQPRKPLAPKPISEPIDISSGDENEDDSNT--------------KTTNGDG--VAAAA 145
            :.|...:|:..:.:.||        .|.|:.||.:..              :..|.|.  |:.:.
  Fly     9 DFMRGYHSEQDEKMKPK--------DSFDKREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQ 65

  Fly   146 APPPPTPAVQGSAL----KRLMEEV---------PEIAVAAKKVAKPN-TIHVSSSEAIQKLHQV 196
            |........:|..:    ||..|.|         |:..:...:|.:.| .:|:|...::|....|
  Fly    66 AKMDELQLFRGDTVILKGKRRKETVCIVLSDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDV 130

  Fly   197 -VGNRAKNLSEDAVPRSKDHRNVPG-------------LYQQLHQNQS---RDRLR--KFKRDLE 242
             .|.|.:.|     |..:....|.|             .|:.:|...:   |..:|  :||..|.
  Fly   131 KYGKRVRIL-----PIDESTEGVTGNLFEIYLKPYFLEAYRPIHMGDNFIVRAAMRPIEFKVVLT 190

  Fly   243 VQHP----------------------TES-----FRDIGGMDSTLKELCEML-IHIKSPEFYFQL 279
            ...|                      .||     :.||||....|.::.||: :.::.|..:..:
  Fly   191 DPEPYCIVAPETVIFCDGDPIKREEEEESLNAVGYDDIGGCRKQLAQIKEMVELPLRHPSLFKAI 255

  Fly   280 GLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSP 344
            |:.|.||:|::||||.|||.:|||::.:.......|...|::..::||||..:|:.|::|...||
  Fly   256 GVKPPRGILMYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSP 320

  Fly   345 CVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRI 409
            .::||||||||...|.....::||||||||::.:|.:|.:   ..::|:|||.||:.:||.|||.
  Fly   321 AIIFIDEIDAIAPKRDKTHGEVERRIVSQLLTLMDGMKKS---SHLIVMAATNRPNSIDPALRRF 382

  Fly   410 GRFDHEIAIHIPSRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKR 474
            ||||.||.|.||....|.|:|||..:.:.:...::.::||..:.|:|||||.:|.|.||
  Fly   383 GRFDREIDIGIPDATGRLEVLRIHTKNMKLHDDVDLEQIAAESHGHVGADLASLCSEAA------ 441

  Fly   475 RSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDK 539
              :::.||       .|..:.|:||                           |:|.:
  Fly   442 --LQQIRE-------KMDLIDLEDD---------------------------KIDAE-------- 462

  Fly   540 SEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSND 604

  Fly   463 ----------------------------------------------------------------- 462

  Fly   605 EYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEK 669
                 .||.|                .:|:.:|..|:....|||.||..:.||:|||.|||.||.
  Fly   463 -----VLASL----------------AVTMENFRYAMTKSSPSALRETVVEVPNTTWTDIGGLES 506

  Fly   670 IREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMN 734
            :::||:..|..||::|:...:.|:....|||..|||||||||||||||||...||||||||||:.
  Fly   507 VKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLT 571

  Fly   735 MYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDG-GDGNNSGTRIVNQLLTEMDGVEER 798
            |:.||||..||..|.:||::||||:||||.||:...|... ||...:..|::||:||||||:..:
  Fly   572 MWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGDAGGAADRVINQILTEMDGMGAK 636

  Fly   799 KGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIA 863
            |.|:|:.|||||||||||||||||||.::|:..|:...|..||||   |.::..||.:|||..||
  Fly   637 KNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAILKA---NLRKSPLAKEVDLTYIA 698

  Fly   864 AQTEGYTGADLAGLVKQASMFSLRQSL--------------NNG-DTNLDDLC--VRSQHFQEAL 911
            ..|:|::||||..:.::|...::||::              |:. |.:.||..  :.|.||:||:
  Fly   699 KVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNSAMDMDEDDPVPEITSAHFEEAM 763

  Fly   912 QQLRPSVNEQDRKIYD 927
            :..|.||::.|.:.|:
  Fly   764 KFARRSVSDNDIRKYE 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	238/665 (36%)
		AAA	287..418	CDD:278434	58/130 (45%)
		P-loop_NTPase	679..>716	CDD:304359	19/36 (53%)
		AAA	699..830	CDD:278434	84/131 (64%)
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	280/880 (32%)
		CDC48_N	47..129	CDD:280513	15/81 (19%)
		CDC48_2	153..213	CDD:215011	8/59 (14%)
		AAA	263..392	CDD:278434	58/131 (44%)
		AAA	536..669	CDD:278434	84/132 (64%)
		Vps4_C	<741..783	CDD:286426	13/39 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445199
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23077
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850