DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and Atad3a

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001030094.1	Gene:	Atad3a / 298682	RGDID:	1305964	Length:	591	Species:	Rattus norvegicus

Alignment Length:	589	Identity:	118/589 - (20%)
Similarity:	228/589 - (38%)	Gaps:	137/589 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 DP-GLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSR 466
            || ||.|..:...|:. |....||...:.::|.:.|.::.:   .|:.|..         |.|.:
  Rat    50 DPTGLERAAKAARELE-HSRHAKEALNLAQMQEQTLQLEQQ---SKLKEYE---------AAVEQ 101

  Fly   467 AASVAVKRRSMKKFRELHAASEKNMTTVTLDD--------DEPSEDAGETPVPDSKGEETAKDAE 523
            ..|..::.::.::.:.|:..:.::.......|        |:..:..........|.||:.:..|
  Rat   102 LKSEQIRVQAEERRKTLNEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQE 166

  Fly   524 AEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEE 588
            |.::...::|...:.|:|               ...:::..:...|:..:..|...:...:...|
  Rat   167 AIRRATVEREMELRHKNE---------------MLRVEAEARARAKADRENADIIREQIRLKAAE 216

  Fly   589 PKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKRE-- 651
            .::.:.:.:.::.:  .:.|...|.:|:: |......|.    |||:    |:.|.  |||..
  Rat   217 HRQTILESIRTAGT--LFGEGFRAFVTDW-DKVTATVAG----LTLL----AVGVY--SAKNATS 268

  Fly   652 ---GFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPS---------------- 697
               .:|..      .:|....:||..:::||..:::|..:.|..::.|.
  Rat   269 VAGRYIEA------RLGKPSLVRETSRISVLEALRHPIQVSRRLVSRPQDALEGVILSPSLEARV 327

  Fly   698 ------------------GVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVG-ESERA 743
                              .||:.||||.||||.||.:|..:|:::..:.|.::..|  | |...|
  Rat   328 RDIAIATRNTKKNKSLYRNVLMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM--GREGVTA 390

  Fly   744 VRACFQRARNS-APCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVY----- 802
            :...|..|..| ...::|.||.|:...||:.        .:|...|...::....|.|.:
  Rat   391 MHKVFDWASTSRRGLLLFVDEADAFLRKRAT--------EKISEDLRATLNAFLHRTGQHSNKFM 447

  Fly   803 ILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTE---------ILKATTKNGKRPVLADDVD 858
            ::.|:|:|:..|.||  ..|:|.::....|::.||..         :||..|: ||:.:.....|
  Rat   448 LVLASNQPEQFDWAI--NDRIDEMVCFALPQREERERLVRMYFDKYVLKPATE-GKQRLKVAQFD 509

  Fly   859 ----LDEIAAQTEGYTGADLAGLVK--QASMFS-----LRQSLNNGDTNLDDLCVRSQHFQEALQ 912
                ..|:|..|.|.:|.::|.|..  ||..:|     |.:::.  |..:.|...:.|...:.|:
  Rat   510 YGKKCSEVAQLTAGMSGREIAQLAVAWQAMAYSSEDGVLTEAMM--DARVQDAVQQHQQKMQWLK 572

  Fly   913 QLRP 916
            ..||
  Rat   573 VERP 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	118/589 (20%)
		AAA	287..418	CDD:278434	6/15 (40%)
		P-loop_NTPase	679..>716	CDD:304359	16/70 (23%)
		AAA	699..830	CDD:278434	40/137 (29%)
Atad3a	NP_001030094.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		1/1 (100%)
		Required for interaction with the inner surface of the mitochondrial outer membrane. /evidence=ECO:0000250	2..49
		DUF3523	27..285	CDD:403305	45/281 (16%)
		S100B-binding. /evidence=ECO:0000250	289..304		3/14 (21%)
		RecA-like_ATAD3-like	323..472	CDD:410920	40/160 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910