DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and Fignl1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001011913.1	Gene:	Fignl1 / 289777	RGDID:	1307112	Length:	677	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	163/633 - (25%)
Similarity:	257/633 - (40%)	Gaps:	128/633 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 LMEIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLIS 376
            :.|:|..    |:.|.|||        |...|..|...::..||.||
  Rat   146 IFEVPQL----GVCGGSEE--------ADLLSSSVHGTEKTQAIPGN------------------ 180

  Fly   377 SLDNLKANEFGQSVVVIAATTRPDVLD---PGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLS 438
               :|:.:.|..::..:|..|:..:..   .|......| |...:...::||.:..
  Rat   181 ---SLRCSPFQSTLFPMATNTKTCLTSSAPSGESTTATF-HRTPLFGNTKKEPQSF--------- 232

  Fly   439 VDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPS- 502
              ||             ....|...:|..:.|.....:.::.:..:.:...||.:....:..||
  Rat   233 --PK-------------TSTGLNMFLSNPSCVPSGCENPRERKAFNDSDTINMLSNPTLNKAPSK 282

  Fly   503 -EDAG---ETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSP 563
             ||:|   :..:|..|   |||    ||.....|:.|.:.:....|.|....|....|.|.....
  Rat   283 TEDSGQREDNSLPTFK---TAK----EQLWADQKKRSHQSQHTSKSFNGAIKKSLGAGRSRGIFG 340

  Fly   564 QKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADP 628
            :..|..|.::  |.:....||.|:..:....:....:....:..||.:.||.      ..|..|.
  Rat   341 KFVPPVSNKQ--DGSEQNGNVKPKSSRAGSAEPAHLTDDRLKNVEPRMVELI------MNEIMDH 397

  Fly   629 NFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGL 693
            .                           |...|:||..:|..:..:|..|:.|:..|::.  .||
  Rat   398 G---------------------------PPVHWEDIAGVEFAKATIKEIVVWPMMRPDIF--TGL 433

  Fly   694 TA-PSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPC 757
            .. |.|:||.||||.||||:.|.||:::|..|.|:....|.:.:|||.|:.|||.|..||...|.
  Rat   434 RGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPA 498

  Fly   758 VIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGV----EERKGVYILAATNRPDIIDPAIL 818
            |||.||.|||..:|.||  .:.|..||..:.|.::||.    |:|  :.::.|||||..||.|..
  Rat   499 VIFIDEIDSLLSQRGDG--EHESSRRIKTEFLVQLDGATTSSEDR--ILVVGATNRPQEIDEAAR 559

  Fly   819 RPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASM 883
            |  ||...||:..||.|.|.:|:  .....|......|.:.:.:..|::|::|||:..|.::||:
  Rat   560 R--RLVKRLYIPLPEASARKQIV--VNLMSKEQCCLTDEETELVVQQSDGFSGADMTQLCREASL 620

  Fly   884 FSLRQSLNNGD--TNLDDLC--VRSQHFQEALQQLRPSVNEQDRKIYD 927
            ..:| ||:..|  |...|..  :....|:.|.:.:||||:.:|.::|:
  Rat   621 GPIR-SLHTADIATISPDQVRPIAYIDFENAFRTVRPSVSPKDLELYE 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	160/623 (26%)
		AAA	287..418	CDD:278434	21/108 (19%)
		P-loop_NTPase	679..>716	CDD:304359	17/37 (46%)
		AAA	699..830	CDD:278434	60/134 (45%)
Fignl1	NP_001011913.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..232		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..324		18/81 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..378		6/42 (14%)
		RecA-like_Figl-1	383..568	CDD:410933	78/225 (35%)
		AAA_lid_3	593..>624	CDD:407720	9/30 (30%)
		Vps4_C	<634..674	CDD:401324	9/34 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900