DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and Nvl

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001099450.1	Gene:	Nvl / 289323	RGDID:	1311270	Length:	855	Species:	Rattus norvegicus

Alignment Length:	1004	Identity:	396/1004 - (39%)
Similarity:	536/1004 - (53%)	Gaps:	228/1004 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKKAKPLLHDHLITIRVKKYLEEHIGETYLDVKQMTRELMQKYP-EYSRRKFGPFRQLVHQAFSI 64
            ||....:..|..:..||.:||..:....|:|...:..:|.:.|. :|.|||...||..|.:.|:|
  Rat     1 MKPRPAVFVDRKLKQRVIQYLSSNRCGKYVDTGILASDLQRMYSVDYGRRKRNAFRIQVEKVFNI 65

  Fly    65 IS---ESYNLDKV-------------------SSSEEDCVSEDSEPPPTNSVMNNMMNSLY---- 103
            ||   |..||.::                   |.|::|...||...|.:.:.||:.:.|||
  Rat    66 ISSEKEHKNLKELEDGHLAKRARQDEDDEYTESYSDDDSNMEDYPDPQSANHMNSSLLSLYRKGN 130

  Fly   104 ---------------------------SQPRKPLAPKP--------------ISEPIDISSGDEN 127
                                       |.|.|..|.:|              .|.|:|:|
  Rat   131 SDSVSTTPKLEQREDATSSPLLSSKTDSMPLKTPAREPEGGWFIDKTPGGQKESLPLDLS----- 190

  Fly   128 EDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQK 192
            :|.||.|..:              |.:|......|:|                      |:..:|
  Rat   191 DDQSNCKKQD--------------PGIQNLKDSSLLE----------------------SDKKRK 219

  Fly   193 LHQVVGNRAKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMD 257
                  :|||.        ..:.|...||.:...:.::..:.|...:..|:|..:..|.|:||.|
  Rat   220 ------SRAKG--------KGNKRKTEGLQEADGEIEAILQKRAKAKSTELQISSVKFEDVGGND 270

  Fly   258 STLKELCEMLIHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIG 322
            :||||:|:||||::.||.|..||::|.||:|||||||||||.||.||:|:|.:|::::.|.|::.
  Rat   271 ATLKEVCKMLIHMRHPEVYQHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVS 335

  Fly   323 GISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFG 387
            |:|||||:::|::||||:..:||::||||||||...|:.||||||||||:||::.:|:|......
  Rat   336 GVSGESEQKLRDLFDQAVSNAPCIVFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAAT 400

  Fly   388 QSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPKLNYDKIAELT 452
            ..|:|:.||.|||.|||.|||.||||.|:.:.||....|..||:..|..|.:....|:..:|.||
  Rat   401 ARVLVVGATNRPDSLDPALRRAGRFDREVCLGIPDEASRERILQTLCRKLRLPETFNFSHLAHLT 465

  Fly   453 PGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEE 517
            ||:||||||||...||..||.|..|::       .|:..|       ||  :.|..|   |.||
  Rat   466 PGFVGADLMALCREAAVCAVHRVLMRR-------QEQQRT-------EP--ETGGLP---SDGE- 510

  Fly   518 TAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVD 582
                                   :|.|...|.|
  Rat   511 -----------------------QGRSLGAEPP-------------------------------- 520

  Fly   583 NVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFL--DNPPEEFADPNFCLTLIDFVDAIKVMQ 645
                             |.:.||     |..|...|  .:|..|......||.|.||:.|:..:|
  Rat   521 -----------------SETQDE-----LQRLLGLLRDQDPISEEQMQGLCLELNDFIVALSEVQ 563

  Fly   646 PSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKT 710
            ||||||||:|||:.||.|:||||.|||||.:|:||||:.||....|||.||:||||.||||||||
  Rat   564 PSAKREGFVTVPNVTWADVGALEDIREELTMAILAPVRNPEQFRALGLVAPAGVLLAGPPGCGKT 628

  Fly   711 LLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGG 775
            |||||:|||:|:||||||||||:||||||||||||..||||:|||||||||||.|:|||:|||..
  Rat   629 LLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRE 693

  Fly   776 DGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEI 840
            .|  :..|:||||||||||:|.|:.|:||||||||||||||||||||||..|:||.|..::|..|
  Rat   694 TG--ASVRVVNQLLTEMDGLETRQQVFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRVAI 756

  Fly   841 LKATTKNGKRPVLADDVDLDEIA--AQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLD--DLC 901
            ||..||||.:|.|.:||||:.||  .:.:.||||||:.||::||:.:|||.:......:.  :|.
  Rat   757 LKTITKNGTKPPLDEDVDLEAIANDHRCDCYTGADLSALVREASLCALRQEITGQKNGIGTAELT 821

  Fly   902 VRSQHFQEALQQLRPSVNEQDRKIYDKLR 930
            |..:||:||.::::||::.:|:::|:.|:
  Rat   822 VSHKHFEEAFRKVKPSISVKDQRMYEALQ 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	22/72 (31%)
		SpoVK	271..919	CDD:223540	315/653 (48%)
		AAA	287..418	CDD:278434	74/130 (57%)
		P-loop_NTPase	679..>716	CDD:304359	27/36 (75%)
		AAA	699..830	CDD:278434	102/130 (78%)
Nvl	NP_001099450.1	Nucleolin_bd	2..71	CDD:406995	21/68 (31%)
Nvl	NP_001099450.1	CDC48	<255..855	CDD:273521	334/695 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352194
Domainoid	1	1.000	212	1.000	Domainoid score	I2697
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1902
Inparanoid	1	1.050	662	1.000	Inparanoid score	I728
OMA	1	1.010	-	-		QHG53526
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102053
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2802
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770