DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and pex6

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_593468.1	Gene:	pex6 / 2542437	PomBaseID:	SPAC17A5.01	Length:	948	Species:	Schizosaccharomyces pombe

Alignment Length:	876	Identity:	220/876 - (25%)
Similarity:	355/876 - (40%)	Gaps:	252/876 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 DDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQKL 193
            |:.|....:.:|..|......|:   .|.|.:..:..:|..:..::|:.|...:.|     :|::
pombe   255 DEFNESVISEEGTEAFLVARGPS---VGIASRISLRTIPTQSCFSEKLLKAANLCV-----VQQV 311

  Fly   194 HQVVGNRAKNL----------SEDAVPRSKDHRNVP-------------GLYQQLHQNQSRDRLR 235
            .|.|..::|.:          :.|:|...:..||..             ..|...:.|:.    .
pombe   312 KQKVFLQSKQIFCVPINSLMANSDSVDILELTRNTDAYIWYSVEEIDPLNTYNIYYTNED----T 372

  Fly   236 KFKRDLEVQH--------PTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGLLPSRG--LLLH 290
            ....|.::.|        |..:|..:......|...|..         :|....:|...  .|||
pombe   373 SIVLDTQLSHRLLPSLRKPLLNFVKVHPPSQKLLRFCRA---------FFDPQQVPGFNPFFLLH 428

  Fly   291 GPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPC-VLFIDEIDA 354
            |.|..|||.....::.....|:..|.:.|.....:...|.:: ::|.|.:..||| ::|:.::|.
pombe   429 GNPFTGKTKAVEEVASLFSAPVFTISSYEFADATADHLEAKL-DMFVQNVVKSPCAIIFVKDLDV 492

  Fly   355 IG-----GNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRP------DVLDPGLRR 408
            :.     ||....||.     :..|:|.:|.:|:.: |:.:|:  .|...      ::|....
pombe   493 LSISSDEGNIVPGSKS-----IQILLSKIDLVKSPQ-GRYIVI--GTCHSIEKIPYEILSESF-- 547

  Fly   409 IGRFDHEIAIHIPSRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVK 473
                 .|:........||.|:|:|....:.:|.:::                      ...||:|
pombe   548 -----FELKFSELEMDERLELLKIYANNVIIDKRIS----------------------LKDVALK 585

  Fly   474 RRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKD 538
            ..|| .|.||                                 |...|...:..||..|.|
pombe   586 TNSM-SFGEL---------------------------------ECLPDHMTKAAVDRIKRT---- 612

  Fly   539 KSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSN 603
                                                   ..|.|::....| ...||:||.|
pombe   613 ---------------------------------------GYDNDSIILSGP-IITEQDVDVS--- 634

  Fly   604 DEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALE 668
                                              ::.|:    ..|.....|||...|||||.||
pombe   635 ----------------------------------INRIR----KEKSNTIFTVPKVNWDDIGGLE 661

  Fly   669 KIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELM 733
            :.:..|:..:..|:::||:..: ||...|||||.||||.||||||||:|.|..:.|:|:|||||:
pombe   662 EAKTVLRDTLQLPLQFPELFSQ-GLKPRSGVLLYGPPGTGKTLLAKAVATELSLEFVSIKGPELL 725

  Fly   734 NMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGV--E 796
            ||||||||..||..|::||||:||||||||.||:.|.|.:..|..|...|:|:|||.|:|.:  :
pombe   726 NMYVGESEANVRNVFEKARNSSPCVIFFDELDSIAPHRGNSSDSGNVMDRVVSQLLAELDSISKD 790

  Fly   797 ERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSE-RTEILKATTKNGKRPVLADDVDLD 860
            ..|.|:::.||||||::||::|||||.|.::|:|..:..| :..:|:|.||..|   |.:.:||:
pombe   791 NNKYVFVIGATNRPDLLDPSLLRPGRFDKLVYLGINKSEESKASMLRALTKTFK---LDETIDLN 852

  Fly   861 EIAAQTE-GYTGADLAGLVKQASMFSLRQSLNNGD-------TNLD--------------DLCVR 903
            |||.... .:||||:..|...|.:.::::..|..|       |:|.              :|.:.
pombe   853 EIAKNCHPNFTGADMYALCSDAVLSAIKRKTNEIDLLIQASGTDLSTEEFFKRNENQDSLELRIT 917

  Fly   904 SQHFQEALQQLRPSVNEQDRKIYDKLRLKYA 934
            .:.|..:|::||||::||:...|:.:|.:::
pombe   918 KEDFLTSLKKLRPSISEQELHRYEMVRHQFS 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	189/686 (28%)
		AAA	287..418	CDD:278434	32/142 (23%)
		P-loop_NTPase	679..>716	CDD:304359	21/36 (58%)
		AAA	699..830	CDD:278434	77/132 (58%)
pex6	NP_593468.1	SpoVK	426..937	CDD:223540	189/671 (28%)
		AAA	426..544	CDD:278434	30/126 (24%)
		P-loop_NTPase	646..>719	CDD:304359	36/73 (49%)
		AAA	691..824	CDD:278434	77/132 (58%)
		Vps4_C	<912..941	CDD:286426	9/28 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810