DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and rvb2

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_595640.1	Gene:	rvb2 / 2541077	PomBaseID:	SPBC83.08	Length:	465	Species:	Schizosaccharomyces pombe

Alignment Length:	447	Identity:	103/447 - (23%)
Similarity:	180/447 - (40%)	Gaps:	118/447 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 GVAAAAAPPPPT--PAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEA-IQKLHQVVGNRA 201
            |.|...|.||.|  .|:.....:.|..:.|.:.::|.:|   .::.:|.:|| :|.|.:.:|.|.
pombe    65 GRAILMAGPPSTGKTAIAMGMAQSLGSDTPFVTLSASEV---YSLEMSKTEALLQALRKSIGVRI 126

  Fly   202 K---NLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGG--MDSTLK 261
            |   .:.|..|...:..|::.|       ...:.:|.....|:|..:      |:|.  :||..|
pombe   127 KEETEIIEGEVVEVQIDRSITG-------GNKQGKLTIRSTDMETVY------DLGTKMIDSLTK 178

  Fly   262 E--LCEMLIHI-KSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLK--------MPLMEI 315
            |  |...:|.| ||.....:||...||. ..:...|....|: :...|:::        :.|.:|
pombe   179 EKVLAGDVISIDKSVGRVTKLGRSFSRA-RDYDAMGADTRFV-QCPQGEIQKRKEVVHTVSLHDI 241

  Fly   316 PATE--------LIGGISGESEERIREVFDQAIG---------YSPCVLFIDEIDAIGGNRQWAS 363
            ....        |..|.:||.:..:||..:..:.         ..|.|||:||:..:
pombe   242 DVINSRTQGFLALFSGDTGEIKPEVREQINTKVSEWREEGKAEIVPGVLFVDEVHML-------- 298

  Fly   364 KDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIG----RFDHEIAIHIPSR- 423
             |:|       ..|..| :|.|...:.:||.|:.|      |:.||.    |..|.|.:.:..|
pombe   299 -DIE-------CFSFFN-RALEDDLAPIVIMASNR------GITRIRGTNYRSPHGIPVDLLDRM 348

  Fly   424 ----------KERREILRIQCEGLSVDPK---LNY-DKIAELTP-GYVGADLMALVSRAASVAVK 473
                      :|.:|||:|:|:...||.:   |:| ..|.:.|. .|.    :.|:|.:..||:|
pombe   349 LIISTLPYSHEEVKEILKIRCQEEDVDMEPSALDYLSTIGQETSLRYA----LLLISSSNQVALK 409

  Fly   474 RRS-------MKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAE 523
            |:|       :::..||....::::        |..|:.|:..:  ::.|.:|..|:
pombe   410 RKSATIEESDIRRVYELFLDQKRSV--------EYLEEYGKNYI--TENEWSASGAQ 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	68/305 (22%)
		AAA	287..418	CDD:278434	33/159 (21%)
		P-loop_NTPase	679..>716	CDD:304359
		AAA	699..830	CDD:278434
rvb2	NP_595640.1	TIP49	10..445	CDD:224145	100/432 (23%)
		P-loop_NTPase	68..>118	CDD:304359	13/52 (25%)
		P-loop_NTPase	<263..356	CDD:304359	25/115 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910