DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and pex1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_587770.1	Gene:	pex1 / 2539405	PomBaseID:	SPCC553.03	Length:	937	Species:	Schizosaccharomyces pombe

Alignment Length:	873	Identity:	211/873 - (24%)
Similarity:	337/873 - (38%)	Gaps:	292/873 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 PPTPAVQGSALKRLMEE---VPEIAVAAKKVAKP------------NTIHVSSSEAIQKLHQVVG 198
            ||      |:.|.::|:   .||..::::.||..            ..:.::.|.::..|..||.
pombe   268 PP------SSSKFILEQKGLPPESNLSSELVAAKLKNSYLMDGMTLKLVDIAVSYSVSGLSGVVK 326

  Fly   199 NRAKNL---SEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTL 260
            |..:::   |:..||.:...||          |..|..::.|..:
pombe   327 NPIQDIKITSDTNVPVNAGIRN----------NSPRLSMQPFPHE-------------------- 361

  Fly   261 KELCEMLIHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMP----LMEIPATELI 321
                  ...:::..|..|       .:.::||.||||:.|..::.....:.    .|.:..:|:.
pombe   362 ------FAQVRNAVFLHQ-------NIYINGPKGCGKSNLVHSLFDYYSLNSIYFQMIVSCSEID 413

  Fly   322 GGISGESEERIREVFDQAIGYSPCVLFIDEIDAI--GGNRQWASKDMERRIVSQLISSLDNLKAN 384
            .....:.:.....||.||..|.|.::::|::..:  ..|.......:|.|.::.|...:.|||..
pombe   414 RSSFAKFQSFWNNVFIQAERYEPSIIYLDDVHCLISSSNENGELGFVEEREIAFLQHQIINLKRK 478

  Fly   385 E------FGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSR--KERREIL-RIQCEGLSVD 440
            .      ||:..:    |...:::.|.|       .:|.|.:||.  ..|:||| .|..|..|..
pombe   479 RKIIFIGFGEEFL----TFSENLVLPLL-------FQIKIALPSLAVTRRKEILTTIFQENFSDI 532

  Fly   441 PKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDA 505
            ...:.:.|:..|.||:..||:..|.|..|
pombe   533 TMDSIEFISVKTEGYLMTDLVLFVKRLLS------------------------------------ 561

  Fly   506 GETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKS 570
                           :|..|:..:|                   ||...|
pombe   562 ---------------EAFVEKIQNG-------------------PKHLMN--------------- 577

  Fly   571 AEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLI 635
                               |..:|:                                     ||.
pombe   578 -------------------KGLIEK-------------------------------------TLK 586

  Fly   636 DFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVL 700
            |||       |...|:.........|.||..:::.:|.::..:.:||||..:.::..|..|:|:|
pombe   587 DFV-------PLQLRKAKFVKSSIRWIDIAGMQEAKEAVRDIIESPVKYSLIYKQCRLRLPTGIL 644

  Fly   701 LCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFD 765
            |.|.||||||.||.||::...:.|||:|||||::.|:|:||:.||..|.||:.:.|||:||||||
pombe   645 LFGYPGCGKTYLASAISSTFPVQFISIKGPELLDKYIGKSEQGVRDLFSRAQMAKPCVLFFDEFD 709

  Fly   766 SLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVG 830
            |:.|:|  |.|......|:|||:||:|||.|...||||:|||.|||:||||:|||||||.:::..
pombe   710 SVAPRR--GQDSTGVTDRVVNQILTQMDGAESLDGVYIVAATTRPDMIDPALLRPGRLDKLIFCD 772

  Fly   831 FPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSL-----RQSL 890
            .|.:.||.|:|:   |...|..:.:...|.:::..|:|||.|||:.|:..|.:.::     |.|:
pombe   773 LPNEEERLEVLQ---KLANRFHIENAAMLKKLSTLTDGYTYADLSSLLYDAHLIAVHKLLKRVSI 834

  Fly   891 NNGD--------TNLDDLCVR-------------SQHFQ----------------EALQQLRPSV 918
            |..|        |||.....|             :|:.|                |||::..||:
pombe   835 NAVDPSQTTSSFTNLTTESKRNASMLALPPESRYNQNMQSMSDSKSVVIEDYMLMEALKKNSPSL 899

  Fly   919 NEQD----RKIYDKLRLKYAAPRVPTLN 942
            |.::    ..:|...|.|...|.:...|
pombe   900 NSEEFEHLSNLYRDFRSKLFEPELNARN 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	183/704 (26%)
		AAA	287..418	CDD:278434	29/142 (20%)
		P-loop_NTPase	679..>716	CDD:304359	18/36 (50%)
		AAA	699..830	CDD:278434	75/130 (58%)
pex1	NP_587770.1	PEX-1N	90..164	CDD:286361
		SpoVK	355..832	CDD:223540	169/673 (25%)
		AAA	375..510	CDD:278434	30/145 (21%)
		AAA	643..773	CDD:278434	75/131 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900