DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and Pex6

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_663463.1	Gene:	Pex6 / 224824	MGIID:	2385054	Length:	981	Species:	Mus musculus

Alignment Length:	698	Identity:	201/698 - (28%)
Similarity:	319/698 - (45%)	Gaps:	172/698 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 GMDSTLKELCEMLIHIKSPEFYFQLG---LLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIP 316
            |:::.:.|||.:|    .|  :.|.|   |..:..:||.||||.|||....|...:|.:.|:::|
Mouse   438 GLEALVNELCAIL----KP--HLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVP 496

  Fly   317 ATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNL 381
            .:.|....|...|.:::..|.:|....|.||.:..:|.:|.:|....:|      :::.::|.:|
Mouse   497 CSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGED------ARVAATLRHL 555

  Fly   382 KANEFGQS----VVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPK 442
            ..:|...|    ::|:|.|:|...|...::.  .|.||:.:.:.|..:|..||:.....|.:..:
Mouse   556 LLDEDALSRCPPLMVVATTSRVQDLPTDVQT--AFPHELEVPVLSEAQRLSILQALTAHLPLGQE 618

  Fly   443 LNYDKIAELTPGYVGADLMALVS---RAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSED 504
            :|..::|....|:|..||.||::   |||...::                           .|..
Mouse   619 VNLPQLARRCAGFVVGDLYALLTHTCRAACTRIR---------------------------ASGS 656

  Fly   505 AGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKK 569
            ||                            ...::.|||
Mouse   657 AG----------------------------GLSEEDEGD-------------------------- 667

  Fly   570 SAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTL 634
                     :.|...                        |.|||
Mouse   668 ---------LCVAGF------------------------PLLAE--------------------- 678

  Fly   635 IDFVDAIKVMQPS-AKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSG 698
             ||..|:..:|.: ::..|...:|..:|.|:|.|:.:::|:...:..|:::||:|. |||.. ||
Mouse   679 -DFGQALDQLQTAHSQAVGAPRIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLS-LGLRR-SG 740

  Fly   699 VLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDE 763
            :||.||||.||||||||:|.|..:.|:|||||||:|||||:||..||..|.|||.:|||:|||||
Mouse   741 LLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDE 805

  Fly   764 FDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILY 828
            .|||.|.|...||......|:|:|||.|:||:...:.|:::.||||||::|||:|||||.|.:::
Mouse   806 LDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVF 870

  Fly   829 VGFPE-QSERTEILKATTKNGKRPVLADDVDLDEIA-AQTEGYTGADLAGLVKQASMFSLRQSLN 891
            ||..| ::.:..:|.|.|:..|   |...|.|..:. ......|||||..|...|.|.:|::.:.
Mouse   871 VGASEDRASQLRVLSAITRKFK---LEASVSLANVLDCCPPQLTGADLYSLCSDAMMTALKRRVR 932

  Fly   892 NGDTNLD----DLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLKYAA 935
            :.:..|:    .|.:..:...:|..:|:|||:||:...|.:::.|:||
Mouse   933 DLEEGLELRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAA 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	189/664 (28%)
		AAA	287..418	CDD:278434	37/134 (28%)
		P-loop_NTPase	679..>716	CDD:304359	22/36 (61%)
		AAA	699..830	CDD:278434	76/130 (58%)
Pex6	NP_663463.1	SpoVK	464..968	CDD:223540	188/652 (29%)
		AAA	467..596	CDD:278434	37/136 (27%)
		AAA	744..872	CDD:278434	74/127 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810