Protein Alignment smid and ZK938.3

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_001364588.1
• Gene: ZK938.3 / 191468
• WormBaseID: WBGene00014160
• Length: 616
• Species: Caenorhabditis elegans
• Alignment Length: 732
• Identity: 135/732 - (18%)
• Similarity: 251/732 - (34%)
• Gaps: 248/732 - (33%)

  Fly   272 SPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLM--EIPATELIGGISGES-EERIR 333
            ||:||   |...::..|||         |...||.|||....  .:|.|.::..::|.: ::.|.
 Worm    26 SPKFY---GTHQTKERLLH---------LVTLISSQLKQLNRGENVPRTRMVSNLAGNARKDLIF 78

  Fly   334 EVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVS-QLISS--LDNLK------------- 382
            |::...|.:...   .|.:.:|.|::    .:::..:|| :::||  ||...
 Worm    79 EIYLNLISFYKT---SDRMVSIEGSQ----TNLKCLLVSAKMLSSFFLDVFTKIPTTHIESGFDE 136

  Fly   383 ---ANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKE---RREILRIQCEG----- 436
               ::.|.|..|.|.:|.|  ::...  .||..:|.:.:....:::   |...|:.|.:.
 Worm   137 FYISHSFTQEDVAITSTWR--MISQA--AIGHHEHHLEVKRACQEQKAFRESFLKTQTDFDIDFE 197

  Fly   437 ----------LSVD----------------PKLNY-----DKIAELTPGYVGADLMALVSRAASV 470
                      ||::                .:.||     ::.|||....|..|     :..|::
 Worm   198 NAEAEQETQLLSIEYAVLIIQKLERKYQAISRRNYVRFVRERAAELHGLKVEID-----ATQAAI 257

  Fly   471 AVKRR-----SMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDG 530
            .::.|     :.|..||:.   ||.:..:.:             .|:|...:  :.||.|:|
 Worm   258 RIQARTRGYFARKLVREMR---EKELNILNM-------------TPESYIRK--RCAERERK--- 301

  Fly   531 DKETSAKDKSEGDSPNI---ETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKA 592
                    :.||.:..:   |..::....|:.:....|..|.....||.   |:.::.|
 Worm   302 --------RKEGLAGGVGGGEIIEQIEEFNTDLAEALKLLKTHFFFPTS---DLTDIKP------ 349

  Fly   593 VEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKRE------ 651
                               :.|...|:|....|.|..| ..::..:..|::.:.:::||
 Worm   350 -------------------SALPIDLNNQETIFRDACF-RGIVSPLAQIELSELTSQREICKIEN 394

  Fly   652 --------GFITVPDTTWDDIGALEKIR-EELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGC 707
                    .|:.....|...:|..:|.: ::.|:..|                    ||.|.|..
 Worm   395 RQFKFDFRSFLVQTVCTPCSLGTWQKQKSKDQKMQWL--------------------LLSGAPDS 439

  Fly   708 GKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQR-ARNSAPCVIFFDEFDSLCPKR 771
            |||..|:||:....:..:.: ...::||    .:|.:....:: |:.....::..|..|.:  |:
 Worm   440 GKTTWARAISRACHVTHVHI-SKNVVNM----GKRKIYTVVKKLAKQEKRLLVSIDRIDVM--KK 497

  Fly   772 SDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSE 836
            .....|......::...|:::..:   |.|.::..|..|  :|.       ||:.:...||
 Worm   498 DPKHKGYTHRQILLRNFLSDLSNI---KFVMVIGMTRVP--LDD-------LDSYISDLFP---- 546

  Fly   837 RTEILKATTKNGKRPVLADDVDLD---------------------EIAAQTEGYTGADLAGLVKQ 880
                |:||..|   |..|...||.                     :|..||:..|..      |.
 Worm   547 ----LQATLSN---PTNATRYDLAVDCLSRNWEQERLPKFPNRIFDIEKQTKDQTRG------KA 598

  Fly   881 ASMFSLRQSLNNGDTNL 897
            |...:.|.|..|..|.|
 Worm   599 AKFVTNRWSAANNKTTL 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247
		CDC48	<242..933	CDD:273521	135/732 (18%)
ZK938.3	NP_001364588.1	IQCD	<253..278	CDD:467745	5/27 (19%)
		AAA	431..545	CDD:459627	27/152 (18%)