Protein Alignment smid and prx-1

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_510386.2
• Gene: prx-1 / 181538
• WormBaseID: WBGene00004191
• Length: 996
• Species: Caenorhabditis elegans
• Alignment Length: 1027
• Identity: 247/1027 - (24%)
• Similarity: 399/1027 - (38%)
• Gaps: 303/1027 - (29%)

  Fly    62 FSIISESYNLDKVSSSEEDCVSEDSEPPPTNSVMNNMM------NSLYSQPR----KPLAPKPIS 116
            :|:|::|.     ||.|.:.:::      ...|..||:      ..:|.|.|    .|.:.||:.
 Worm   115 YSVIAQSQ-----SSIENEFLNQ------IRLVSQNMIIPHFLSPGVYVQFRILNIVPASNKPVM 168

  Fly   117 EPID-------ISSGDENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRL-------MEEVP 167
            ...|       ::.|.:|::    |.|....|         :..||..:::..       :|:.|
 Worm   169 LNNDTELHVQTVTEGSQNDE----KATMAQKV---------SNIVQDLSMQGFLSNYVINLEKTP 220

  Fly   168 EIA-VAAKKVAK-----------PNTIHVSSSEA-IQKLHQVVGNRAKNLSEDAVPRSKD---HR 216
            .|. |..||..:           .:||::...|: :...|.:|..|::...|:. .|.:.   ||
 Worm   221 IIGRVLPKKTVELWVKSGLEKLDKSTIYIPGKESCLYSEHGIVEIRSQGRGENE-ERFQFFYLHR 284

  Fly   217 NVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGL 281
            : |.:|.   :|||.:      .|..:.|..||.:        |:..|..:....:.|
 Worm   285 S-PNIYL---RNQSNE------LDASLSHMFESLQ--------LENRCHCVEGTNTLE------- 324

  Fly   282 LPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCV 346
                                         |.|.|.       |.|.::.||            |.
 Worm   325 -----------------------------PYMNIK-------IFGVTQNRI------------CT 341

  Fly   347 LFIDEIDAIGGNRQWASKDMERRIVSQLISSL-DNLKANEFGQSVVVIAATTRPDVLDPGLRRIG 410
            |...||.......||. |:.|  :.:.|..|| ..|:.|                   |.|..:.
 Worm   342 LRYCEIMMEKETFQWV-KEFE--LTNVLTKSLHSELQGN-------------------PILLSVE 384

  Fly   411 RFDHEIAIH--------IPSRKERREILRIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRA 467
            ..:.::|:.        :||.|           ||......|...:.:||...:...|..|..:.
 Worm   385 GKELDVAVDDKAIRLKVVPSMK-----------GLVKRVTENTCFLFDLTTELIFQQLGDLKQKH 438

  Fly   468 ASVAVKRRSMKKFRELHAASE--KNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDG 530
            ......||..|:..|..|:.:  :...|.|:::...:::.....:    |..:...:|.::...|
 Worm   439 GDTENTRRRRKRTEEAEASEQIPQKPETSTMENFGFAQNKHFVQI----GSHSKLLSELDKVCCG 499

  Fly   531 DKE--TSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTP---------------------KKSAE 572
            .|:  ........|.:..|:...:..:.|||:...:..|                     :...:
 Worm   500 GKQHVMVLGGNGSGKTTFIKKLARRLSHNSSVTFCKMVPCALLKGRSADIIEKLLSDTLHEMEVK 564

  Fly   573 KPTDAAM-DVDNVAP----EEPKKAVEQEVD-------------------SSSSNDEYYEPT--- 610
            ||:...: |.|.:.|    |:...|:|:.|.                   .||.||.:.|..
 Worm   565 KPSCLFLDDFDVILPQIDQEQRHLAMEKVVSVFAQKLRTTEVSVVLVAQRLSSLNDGFVEQVMRA 629

  Fly   611 ---------LAELT---------NFLDNPPEE--------------FADPNFCLTLIDFVDAIK- 642
                     |.:||         .|||.|...              |::.......|:...|||
 Worm   630 RPIVSRKIELEQLTKEDRCEIFETFLDLPENSDIISEIVKKSDGYTFSEIEKLAVSINVECAIKG 694

  Fly   643 ----------------VMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERL 691
                            |.....|.|....:|  |.:|:|.:.:.::.|:..::.|.|||::.|.:
 Worm   695 VKYITEIEVEKAFECFVAGKMGKIEDGQVLP--TMEDVGGMFEQKKLLEQVIIWPRKYPQLFESV 757

  Fly   692 GLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAP 756
            |:....|:||.||.||||||||.|..:.:..:.::||||||::.|:|.||..||..|::||:.||
 Worm   758 GVPVSKGILLHGPSGCGKTLLANATISNSNFSVVNVKGPELLSKYIGASEENVRLVFEKARSCAP 822

  Fly   757 CVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVE-ERKGVYILAATNRPDIIDPAILRP 820
            |::||||.|||.|||  |.|......|:|||||||:||.| ..|||.||..|:|.|:||.|:|||
 Worm   823 CILFFDELDSLAPKR--GHDSTGVTDRVVNQLLTELDGAEGGMKGVIILGCTSRIDLIDDALLRP 885

  Fly   821 GRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFS 885
            ||.|..:|.|.||::||.:|:|..| |..:|.   |||.:.:|.:|:|::||||..|...|..::
 Worm   886 GRFDHHVYCGHPEKTERLDIMKVLT-NKLKPT---DVDFECLAQKTDGWSGADLQLLFTNAQFYN 946

  Fly   886 LRQ------SLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRL 931
            .||      .|...:..:|...:.|. |.:::.  :|..::.|.:|..|:.|
 Worm   947 ARQIAKEEDGLEEDNVPIDQASIESV-FNDSIP--KPKRSQVDNRIGQKVTL 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247	3/8 (38%)
		CDC48	<242..933	CDD:273521	202/807 (25%)
prx-1	NP_510386.2	PEX-1N	103..179	CDD:462729	16/74 (22%)
		P-loop containing Nucleoside Triphosphate Hydrolases	481..>522	CDD:476819	6/44 (14%)
		CDC48	<504..952	CDD:273521	143/455 (31%)
		RecA-like_PEX1_r2	736..894	CDD:410934	79/159 (50%)