DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and mac-1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_496814.1	Gene:	mac-1 / 174974	WormBaseID:	WBGene00003119	Length:	813	Species:	Caenorhabditis elegans

Alignment Length:	974	Identity:	346/974 - (35%)
Similarity:	499/974 - (51%)	Gaps:	220/974 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DHLITIRVKKYLEEHIGETYLDVKQMTRELMQKYPEYSRRKFGPFRQLVHQA---FSIISESYNL 71
            |..:..||:.::.:..|..|...:.:..:|.|::|||.|:....|..:|.:|   ..::::..|.
Worm    10 DPALLPRVQAHIRKFPGTKYFKPELVAYDLQQEHPEYQRKNHKVFMGMVREALERIQLVAKEEND 74

  Fly    72 DKVSSSEEDCVSEDSEPPPTNSVMNNMMNSLYSQPRKPLAPKPISEPIDISSGDENEDDSNTKTT 136
            :|:   ||....:|.:..|....:........:..||.......::.:.:|  |::||:...:..
Worm    75 EKM---EEKEAMDDVQEIPIVKALETRKRKAPAAGRKSTGQAAAAKEVVLS--DDSEDERAARQL 134

  Fly   137 NGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNRA 201
            .                .|..:||........:.:..||.|....:....::|.:|      ...
Worm   135 E----------------KQIESLKTNRANKTVLNLYTKKSAPSTPVSTPKNQATKK------PPG 177

  Fly   202 KNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTES---FRDIGGMDSTLKEL 263
            .:.:..|:||        ||      ....|.:          .|.||   |..|||.|....|:
Worm   178 ASAAPPALPR--------GL------GAVSDTI----------SPRESHVKFEHIGGADRQFLEV 218

  Fly   264 CEMLIHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGES 328
            |.:.:|:|.|:.:..||:.|.||.::|||||||||..|:|::|:|.:|::::.||||:.|:|||:
Worm   219 CRLAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGET 283

  Fly   329 EERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNL------------ 381
            ||:||.:||.|...|||:|.:|:||||...|:.|.::||||:||||.||||.|
Worm   284 EEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELVLPPREKPLKDQ 348

  Fly   382 --------------KANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRI 432
                          .....|..|:||..|:|||.:|.||||.|||::||::.||....|.:||..
Worm   349 LTFGDDGSVAIIGDSPTAAGAGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILEK 413

  Fly   433 QCE-GLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTL 496
            .|: .|:.|..|.  :||:||||||||||.||:..||.||:.|
Worm   414 ICKVNLAGDVTLK--QIAKLTPGYVGADLQALIREAAKVAIDR---------------------- 454

  Fly   497 DDDEPSEDAGETPVPDSKGEETAKDAEAEQKVD-------GDKETSAKDKSEGDSPNIETPKKAT 554
                    ..:|.|..::|.:.....:.::::|       ||.:.||
Worm   455 --------VFDTIVVKNEGHKNLTVEQIKEELDRVLAWLQGDDDPSA------------------ 493

  Fly   555 NGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLD 619
                                                                    |:||...|.
Worm   494 --------------------------------------------------------LSELNGGLQ 502

  Fly   620 NPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKY 684
                        ::..||..|:..:||:||||||.||||.:|||||||.::|::|:.::|.|:|.
Worm   503 ------------ISFEDFERALSTIQPAAKREGFATVPDVSWDDIGALVEVRKQLEWSILYPIKR 555

  Fly   685 PEMLERLGLTA-PSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACF 748
            .:....||:.. |.|:||||||||||||||||:|||.|:||||||||||:||||||||||||..|
Worm   556 ADDFAALGIDCRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVF 620

  Fly   749 QRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDII 813
            ||||:|.||||||||.|:|.||||.|  .::.|.|:||||||||||||.|:.|:::.|||||||:
Worm   621 QRARDSQPCVIFFDEIDALVPKRSHG--ESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRPDIV 683

  Fly   814 DPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTE--GYTGADLAG 876
            |.|||||||||.||:|.||...:|.:||:.:||||.||:|.:|:|..|||...|  |:||||||.
Worm   684 DAAILRPGRLDKILFVDFPSVEDRVDILRKSTKNGTRPMLGEDIDFHEIAQLPELAGFTGADLAA 748

  Fly   877 LVKQASMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLR----LKYAAP 936
            |:.::|:.:|:..:...|.::..:.:|  ||:||..::||||.|.|||.|:.::    ||.|.|
Worm   749 LIHESSLLALQARVLENDESVKGVGMR--HFREAASRIRPSVTEADRKKYEHMKKIYGLKQATP 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	14/63 (22%)
		SpoVK	271..919	CDD:223540	285/684 (42%)
		AAA	287..418	CDD:278434	71/156 (46%)
		P-loop_NTPase	679..>716	CDD:304359	22/37 (59%)
		AAA	699..830	CDD:278434	98/130 (75%)
mac-1	NP_496814.1	Nucleolin_bd	5..65	CDD:318849	14/54 (26%)
mac-1	NP_496814.1	TIP49	<191..804	CDD:332389	303/744 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165945
Domainoid	1	1.000	203	1.000	Domainoid score	I1730
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1902
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S933
OMA	1	1.010	-	-		QHG53526
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102053
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1718
SonicParanoid	1	1.000	-	-		X2802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.700