Protein Alignment smid and mac-1

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_496814.1
• Gene: mac-1 / 174974
• WormBaseID: WBGene00003119
• Length: 813
• Species: Caenorhabditis elegans
• Alignment Length: 974
• Identity: 346/974 - (35%)
• Similarity: 499/974 - (51%)
• Gaps: 220/974 - (22%)

  Fly    10 DHLITIRVKKYLEEHIGETYLDVKQMTRELMQKYPEYSRRKFGPFRQLVHQA---FSIISESYNL 71
            |..:..||:.::.:..|..|...:.:..:|.|::|||.|:....|..:|.:|   ..::::..|.
 Worm    10 DPALLPRVQAHIRKFPGTKYFKPELVAYDLQQEHPEYQRKNHKVFMGMVREALERIQLVAKEEND 74

  Fly    72 DKVSSSEEDCVSEDSEPPPTNSVMNNMMNSLYSQPRKPLAPKPISEPIDISSGDENEDDSNTKTT 136
            :|:   ||....:|.:..|....:........:..||.......::.:.:|  |::||:...:..
 Worm    75 EKM---EEKEAMDDVQEIPIVKALETRKRKAPAAGRKSTGQAAAAKEVVLS--DDSEDERAARQL 134

  Fly   137 NGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAKPNTIHVSSSEAIQKLHQVVGNRA 201
            .                .|..:||........:.:..||.|....:....::|.:|      ...
 Worm   135 E----------------KQIESLKTNRANKTVLNLYTKKSAPSTPVSTPKNQATKK------PPG 177

  Fly   202 KNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTES---FRDIGGMDSTLKEL 263
            .:.:..|:||        ||      ....|.:          .|.||   |..|||.|....|:
 Worm   178 ASAAPPALPR--------GL------GAVSDTI----------SPRESHVKFEHIGGADRQFLEV 218

  Fly   264 CEMLIHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGES 328
            |.:.:|:|.|:.:..||:.|.||.::|||||||||..|:|::|:|.:|::::.||||:.|:|||:
 Worm   219 CRLAMHLKRPKTFATLGVDPPRGFIVHGPPGCGKTMFAQAVAGELAIPMLQLAATELVSGVSGET 283

  Fly   329 EERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNL------------ 381
            ||:||.:||.|...|||:|.:|:||||...|:.|.::||||:||||.||||.|
 Worm   284 EEKIRRLFDTAKQNSPCILILDDIDAIAPRRETAQREMERRVVSQLCSSLDELVLPPREKPLKDQ 348

  Fly   382 --------------KANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRI 432
                          .....|..|:||..|:|||.:|.||||.|||::||::.||....|.:||..
 Worm   349 LTFGDDGSVAIIGDSPTAAGAGVLVIGTTSRPDAVDGGLRRAGRFENEISLGIPDETAREKILEK 413

  Fly   433 QCE-GLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTL 496
            .|: .|:.|..|.  :||:||||||||||.||:..||.||:.|
 Worm   414 ICKVNLAGDVTLK--QIAKLTPGYVGADLQALIREAAKVAIDR---------------------- 454

  Fly   497 DDDEPSEDAGETPVPDSKGEETAKDAEAEQKVD-------GDKETSAKDKSEGDSPNIETPKKAT 554
                    ..:|.|..::|.:.....:.::::|       ||.:.||
 Worm   455 --------VFDTIVVKNEGHKNLTVEQIKEELDRVLAWLQGDDDPSA------------------ 493

  Fly   555 NGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLD 619
                                                                    |:||...|.
 Worm   494 --------------------------------------------------------LSELNGGLQ 502

  Fly   620 NPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKY 684
                        ::..||..|:..:||:||||||.||||.:|||||||.::|::|:.::|.|:|.
 Worm   503 ------------ISFEDFERALSTIQPAAKREGFATVPDVSWDDIGALVEVRKQLEWSILYPIKR 555

  Fly   685 PEMLERLGLTA-PSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACF 748
            .:....||:.. |.|:||||||||||||||||:|||.|:||||||||||:||||||||||||..|
 Worm   556 ADDFAALGIDCRPQGILLCGPPGCGKTLLAKAVANETGMNFISVKGPELLNMYVGESERAVRTVF 620

  Fly   749 QRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDII 813
            ||||:|.||||||||.|:|.||||.|  .::.|.|:||||||||||||.|:.|:::.|||||||:
 Worm   621 QRARDSQPCVIFFDEIDALVPKRSHG--ESSGGARLVNQLLTEMDGVEGRQKVFLIGATNRPDIV 683

  Fly   814 DPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTE--GYTGADLAG 876
            |.|||||||||.||:|.||...:|.:||:.:||||.||:|.:|:|..|||...|  |:||||||.
 Worm   684 DAAILRPGRLDKILFVDFPSVEDRVDILRKSTKNGTRPMLGEDIDFHEIAQLPELAGFTGADLAA 748

  Fly   877 LVKQASMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLR----LKYAAP 936
            |:.::|:.:|:..:...|.::..:.:|  ||:||..::||||.|.|||.|:.::    ||.|.|
 Worm   749 LIHESSLLALQARVLENDESVKGVGMR--HFREAASRIRPSVTEADRKKYEHMKKIYGLKQATP 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247	14/63 (22%)
		CDC48	<242..933	CDD:273521	303/734 (41%)
mac-1	NP_496814.1	Nucleolin_bd	5..65	CDD:465247	14/54 (26%)
		CDC48	<191..804	CDD:273521	303/744 (41%)