DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and cdc-48.1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_496273.1	Gene:	cdc-48.1 / 174624	WormBaseID:	WBGene00007352	Length:	809	Species:	Caenorhabditis elegans

Alignment Length:	892	Identity:	279/892 - (31%)
Similarity:	417/892 - (46%)	Gaps:	248/892 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 DENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSAL----KRLMEEVPEIAVAAKKVAKPNTIHVS 185
            |::|.|.|:.      :|.:.|........:|.|:    |:..|.|   |:.....:.||
Worm    35 DQSEQDDNSV------IAVSQAKMDELGLFRGDAVILKGKKRKESV---AIIVSDESCPN----- 85

  Fly   186 SSEAIQKLHQVVGNR-------------AKNLSE----DAVPRSKDHRNVPG------------- 220
              |.: ::::||.|.             |.|||.    ..:|.......:.|
Worm    86 --EKV-RMNRVVRNNLRIRLGDVVSITPAPNLSYGTRIHVLPIDDTIEGLTGNLFDVFLKPYFLE 147

  Fly   221 LYQQLHQN-----QSRDRLRKF--------------------------KRDLEVQHPTE-SFRDI 253
            .|:.||:.     |:..|..:|                          ||:.|.:...: .:.|:
Worm   148 AYRPLHKGDIFTVQAAMRTVEFKVVETEPAPACIVSPDTMIHYEGDPIKREEEEESMNDIGYDDL 212

  Fly   254 GGMDSTLKELCEML-IHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPA 317
            ||:...|.::.||: :.::.|:.:..:|:.|.||:||.||||.|||.:|||::.:.......|..
Worm   213 GGVRKQLAQIKEMVELPLRHPQLFKAIGIKPPRGILLFGPPGTGKTLIARAVANETGSFFFLING 277

  Fly   318 TELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLK 382
            .|::..:|||||..:|:.|::.....|.:|||||||||...|:..:.::||||||||::.:|.:|
Worm   278 PEVMSKMSGESESNLRKAFEECEKNQPAILFIDEIDAIAPKREKTNGEVERRIVSQLLTLMDGVK 342

  Fly   383 ANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDPKLNYDK 447
            ..   .::||||||.||:.:|..|||.||||.||.|.||....|.|||||..:.:.:...::.::
Worm   343 GR---SNLVVIAATNRPNSIDGALRRFGRFDREIDIGIPDAVGRLEILRIHTKNMKLADDVDLEQ 404

  Fly   448 IAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPD 512
            ||....|:|||||.:|.|.||        :::.||       .|..:.|:||
Worm   405 IANECHGFVGADLASLCSEAA--------LQQIRE-------KMELIDLEDD------------- 441

  Fly   513 SKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDA 577

Worm   442 ----------------------------------------------------------------- 441

  Fly   578 AMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIK 642
                              ::|             ||:.|.|            .:|:.:|..|..
Worm   442 ------------------QID-------------AEVLNSL------------AVTMENFRFAQG 463

  Fly   643 VMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGC 707
            ...|||.||..:..|:|||.|||.|:.::.||:..|..||::||...:.|:....|||..|||||
Worm   464 KSSPSALREAVVETPNTTWSDIGGLQNVKRELQELVQYPVEHPEKYLKFGMQPSRGVLFYGPPGC 528

  Fly   708 GKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRS 772
            ||||||||||||...||||:|||||:.|:.||||..||..|.:||.:||||:||||.||:...|.
Worm   529 GKTLLAKAIANECQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCVLFFDELDSIAKARG 593

  Fly   773 D--GGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQS 835
            .  ||||..:..|::||:||||||:..:|.|:|:.|||||||||||:|||||||.::|:..|:::
Worm   594 GGAGGDGGGASDRVINQVLTEMDGMNAKKNVFIIGATNRPDIIDPAVLRPGRLDQLIYIPLPDEA 658

  Fly   836 ERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLN--------- 891
            .|.:||||:.:  |.| |:.|:||..:|..|.|::||||..:.::|...::|:|:.
Worm   659 SRHQILKASLR--KTP-LSKDLDLTFLAKNTVGFSGADLTEICQRACKLAIRESIEKEIRIEKER 720

  Fly   892 -----NGDTNLDDLCV------RSQHFQEALQQLRPSVNEQDRKIYD 927
                 .|:..::|..|      ...||:||::..|.||.:.|.:.|:
Worm   721 QDRQARGEELMEDDAVDPVPEITRAHFEEAMKFARRSVTDNDIRKYE 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	237/669 (35%)
		AAA	287..418	CDD:278434	60/130 (46%)
		P-loop_NTPase	679..>716	CDD:304359	20/36 (56%)
		AAA	699..830	CDD:278434	84/132 (64%)
cdc-48.1	NP_496273.1	CDC48_N	31..112	CDD:280513	18/93 (19%)
		CDC48	52..775	CDD:273521	273/869 (31%)
		CDC48_2	137..197	CDD:215011	6/59 (10%)
		AAA	247..376	CDD:278434	60/131 (46%)
		AAA	520..654	CDD:278434	84/133 (63%)
		Vps4_C	<727..771	CDD:286426	12/41 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820