DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and AgaP_AGAP011743

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_320769.4	Gene:	AgaP_AGAP011743 / 1280899	VectorBaseID:	AGAP011743	Length:	902	Species:	Anopheles gambiae

Alignment Length:	980	Identity:	190/980 - (19%)
Similarity:	312/980 - (31%)	Gaps:	305/980 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 AKKVAKPNTIHVSSSEAIQKLHQVVGNRAKNLSEDAVPRSKD----HRNVPGL---YQQLHQNQS 230
            ||.|||   ..:::::.:.  |.:...:...|:|.    :||    ||.|..|   |.||    .
Mosquito     4 AKAVAK---FWITTTDLLD--HVLKHEKRIQLAEP----TKDGRIVHRLVSDLFCRYVQL----C 55

  Fly   231 RDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGLLPSRGLLLHGP--- 292
            |...|.:.:.|:||......:.:....:.:.||...|..|:..||.:..|.|..:.|:   |
Mosquito    56 RSLERCYDQTLQVQKRAVIQQLLEAGQARMLELRTKLQEIELSEFVYVDGALQEQHLI---PDDV 117

  Fly   293 --------PGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEE------------------- 330
                    |......|...:..|...|.:|..:....|..|.|||:
Mosquito   118 LAVRPCYFPARRPDELQALLDAQKLPPFIEPGSDAEDGSSSDESEQPEEEQAALNLITAHERARQ 182

  Fly   331 -RIREV-------------FDQAIGYSPCVLF--------------------------IDEIDAI 355
             |:|:.             .|:.|...|...|                          :|:..|
Mosquito   183 ARVRQTNFRLHPDRYYPKPIDEEIVDVPYEFFYRPGQFMLYPVKRTVYNWDFRMKKKDVDDAAA- 246

  Fly   356 GGNRQWASKDMERRIVSQL------------------ISSLDNLKANEFGQS------------- 389
                :.|..:..:|:...|                  .::|...|.:.|.:|
Mosquito   247 ----ELAQVEAAKRLEEALERIRLNRAAAKIQRYWRKFNALKAQKKHRFDRSKFLGLFDDYEPKL 307

  Fly   390 -----VVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLS----------- 438
                 |..:.|..|        .|...||......|...|.|  ||||:...|.
Mosquito   308 GDALAVAEVRAARR--------ARQPEFDRSFVAAIADEKAR--ILRIRGPALLEDITDFVRAWF 362

  Fly   439 ---VDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDE 500
               .|..|.:|.|.|  |...|..|:          |:..::.....|....:|.:..:...:.:
Mosquito   363 REWYDETLAFDLIPE--PFQGGTVLI----------VRGETLTPLEYLALERQKQLDKLKTPEQK 415

  Fly   501 PSEDAGETPVPDSKGEETAKDAEAEQKVDGD-------KETSAKDKSEGDSPNIETPKKATNGNS 558
            ..|         :...:.||:.|.|:|.:..       :|..|:::.||.:.:...|:..||...
Mosquito   416 KKE---------ADAMKAAKEREQEKKREEKARLKELAREKRARERKEGKTYDFTEPEFMTNAYL 471

  Fly   559 SIKSPQKTPKKS----------AEKPTDAAMDVDNVAPEEPKKAVEQEVDSS-----SSNDEYYE 608
            :::......:|.          .:.|....:.:|..|      .|.||:.:.     .|..|..:
Mosquito   472 TLEETLARYRKDWAFVNELDNLQDLPIMEWITLDKFA------EVHQELHAEVHELLKSERELLQ 530

  Fly   609 PTLAELTNFLDNPP----------------EEFADPNFCLTLIDFVDAI---KVMQPSAKREGFI 654
            ..|.:.......||                :|..||...|::...::.:   .|::...||
Mosquito   531 MALCKDERMKYKPPKPKKPPRAKGAKGKKRKEPIDPTADLSVESILNELVERNVLKTCRKR---- 591

  Fly   655 TVPDTTWD-DIGALEK--------------IREELK--LAVLAPVKYPEMLERLGLTAPSGVLLC 702
            |..|...| :..|.|:              :|..|:  |..:.|:..|:         |..:.|.
Mosquito   592 TFEDYIGDFNYAAFERRNRLEQDPPPGMGEVRTILQSYLYGMGPLAAPK---------PKSLCLV 647

  Fly   703 GPPGCGKTLLAKAIANEAGINFISVK----GPELMNMYVGESERAVRACFQRARNSAPCVIFFD- 762
            ||||.|||||.:||.||.|.....:.    ||...|......:..:||    ||...|.|:..:
Mosquito   648 GPPGYGKTLLLEAICNETGSTLFDLSVDTCGPIEPNNMAHFLQLVLRA----ARLLQPSVLAIEG 708

  Fly   763 ---EFDSLCPKRSDGGD----GNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRP 820
               .|....|:.....|    |.:....||.||..| |.|       :|..|:.    .|.:.:.
Mosquito   709 VHRGFYKKVPQPEQPLDPAKLGKHLFKLIVKQLKPE-DKV-------LLVGTSD----QPWVAKV 761

  Fly   821 GRL----DTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQA 881
            |.|    |.||.:..|:......:.:...:  :.|.:..|:||..:|..|.||:...:....:|.
Mosquito   762 GPLKKCFDKILLLPRPDYGSTVLLWQYALR--RFPTVPRDLDLSALAKVTTGYSAGQILECAQQV 824

  Fly   882 SMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQ-------DRKIYDKLRLKYAAPRVP 939
            .....|.........:.:|.   .||........|..:::       .||: |||    |..|..
Mosquito   825 LNIRRRMQFGRKPLQVGELL---DHFLAGTTPQYPIADKEYEKFVKWHRKV-DKL----AKQRAK 881

  Fly   940 TLNDK 944
            .:.::
Mosquito   882 VMRER 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	157/841 (19%)
		AAA	287..418	CDD:278434	33/236 (14%)
		P-loop_NTPase	679..>716	CDD:304359	13/36 (36%)
		AAA	699..830	CDD:278434	43/146 (29%)
AgaP_AGAP011743	XP_320769.4	AAA	617..>664	CDD:99707	18/55 (33%)
		AAA	640..778	CDD:214640	44/162 (27%)
		AAA	644..776	CDD:278434	43/147 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810