DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and AgaP_AGAP011967

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_320566.3	Gene:	AgaP_AGAP011967 / 1280704	VectorBaseID:	AGAP011967	Length:	782	Species:	Anopheles gambiae

Alignment Length:	848	Identity:	152/848 - (17%)
Similarity:	274/848 - (32%)	Gaps:	286/848 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 LYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEM---LIHIKSPEFYFQLGLL 282
            :|.|:.|.|.|..:||.                  :|:.|..:.|:   |:.|...||.:...::
Mosquito    37 IYDQIVQPQKRILIRKL------------------LDNCLGRMLELKHDLVIIDMTEFSYNDAIV 83

  Fly   283 PSRGLLLHGPPGCGKTFLARAISGQLKMPL-MEIPATELIGGISGESEERIREVFDQAIGYSPCV 346
            ...||                      .|| ||:.....   ...|.||::.|          ..
Mosquito    84 EKLGL----------------------TPLSMEVAVPRY---FRREREEQLNE----------RK 113

  Fly   347 LFIDEI-DAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIG 410
            .|:|:| ..||.        ::..:|.:.:|.|:.::         :|....|        .|.|
Mosquito   114 KFMDDILKKIGA--------LDEEVVEEELSELEAIR---------IIQTHER--------ARQG 153

  Fly   411 RFDHEIAIHIPSRKER--------------REILRIQ--CEGLSVDPKLNYDKIAELTPGYVGAD 459
            |...:....:...||:              ...::||  ..|.:...:....|:.|:.  .:|.
Mosquito   154 RLRAQFMKELKLLKEKGKPDSSRDKSTTGLNAAMKIQKTWRGYATRRQTRRKKMEEMI--LIGM- 215

  Fly   460 LMALVSRAASVAVKRRSMKKFR--------------------ELHAASEKNMTTVTLDD------ 498
            :.|.|:.|.:...:...:|:||                    |:.......||....|:
Mosquito   216 VPAPVTSARTALDELEDLKQFRYKQQKTFQDDYERSLVRVKEEISVKQGAAMTEDIADEIRTWFK 280

  Fly   499 ----------DEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGD---SPNIETP 550
                      |.|||:||                       |.:...::..:|.:   |..:.:.
Mosquito   281 EYQKRTGRLPDFPSEEAG-----------------------GSRHLLSRQGTESEMSRSSVLSSR 322

  Fly   551 KKATNGNSSIKSPQKTP-KKSAEKPTDAAM-DVDNVAPEEPKKAVEQEVDSSSSNDE-------Y 606
            :....|:...|..||.| :.|.|:..|.|. .:.:....|.|..:|:..:.....||       |
Mosquito   323 ESKLKGSGKEKLAQKKPGELSLEEGLDKAFKPMQSSFLPEIKSGIEEYTEVWKGKDESQNLRQTY 387

  Fly   607 YEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAI---------------------KVMQPSAKR 650
            |:..:.|         |::||....|..|  ||.|                     |.....|:|
Mosquito   388 YDDMIYE---------EKYADVEAELRRI--VDEIMRQELELLQIALERDRGGKKLKKSSKKARR 441

  Fly   651 EG---------FITVPDTTWDDI-------GALEK---------------------------IRE 672
            .|         .:| ||.|.:.:       |.::|                           :|:
Mosquito   442 SGKKGKKKKDKDLT-PDRTTESLFEELVTNGIIKKYPETPIKSYVGDLSYAARSALNPSPGDVRQ 505

  Fly   673 ELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYV 737
            .:|...:.|:. .|.:...|....| :|:.||.|.|||.|..||..|.|.....:..|.::..|.
Mosquito   506 LIKQYCILPLG-SETIRNFGPCIKS-LLIAGPKGSGKTSLVHAICTETGSVLFDISPPNIVGKYP 568

  Fly   738 GESE--RAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKG 800
            |:|.  ..:....:.:|...|.||:|.:.:....|:....| .....|:...|...:..::....
Mosquito   569 GKSGLIMLMHLISKVSRLLQPSVIYFGDAEKPFMKKIPKTD-RTDPKRLKKDLPKLVKNIQPEDR 632

  Fly   801 VYILAATNRPDIIDPAILRPGRLDT---ILYVGFPEQSERT----EILKATTKNGKRPVLADDVD 858
            :.::..::.|...|..::    :.|   .:|:..|:....:    |:|...:...::      .|
Mosquito   633 IMLIGTSDCPWEGDMKLM----VQTYQRFIYIPRPDYGALSFAWKELLSHYSGVHRQ------FD 687

  Fly   859 LDEIAAQTEGYTGADLAGLVKQA----SMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVN 919
            ...:|..::|||...:...:::.    .|..||.   :..|:|:.:        .||..|.|...
Mosquito   688 TGAMAKISDGYTIGSVVRCIREVITCKRMLQLRV---HPLTHLELI--------NALSALEPVYK 741

  Fly   920 EQD 922
            |::
Mosquito   742 EEE 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	139/790 (18%)
		AAA	287..418	CDD:278434	22/132 (17%)
		P-loop_NTPase	679..>716	CDD:304359	12/36 (33%)
		AAA	699..830	CDD:278434	29/135 (21%)
AgaP_AGAP011967	XP_320566.3	SpoVK	<454..745	CDD:223540	59/316 (19%)
AgaP_AGAP011967	XP_320566.3	P-loop_NTPase	530..639	CDD:304359	25/109 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810