DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and AgaP_AGAP006205

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_316268.4	Gene:	AgaP_AGAP006205 / 1276867	VectorBaseID:	AGAP006205	Length:	1020	Species:	Anopheles gambiae

Alignment Length:	1046	Identity:	491/1046 - (46%)
Similarity:	634/1046 - (60%)	Gaps:	148/1046 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KKAKPLLHDHLITIRVKKYLEEHIGETYLDVKQMTRELMQKYPEYSRRKFGPFRQLVHQAFSIIS 66
            :|..|..:|.:|..|||:||||::.:||:|...|.|||.|:|.||:|||..|||.||.:|:..:.
Mosquito     3 RKTSPFPYDPMIIPRVKQYLEENVHQTYVDTGVMARELQQRYREYNRRKANPFRLLVEEAYRTVL 67

  Fly    67 ESYNLDKVSSSE-EDCVSEDSEPPPTNSVMNNMMN---SLYSQPRKPLA-----PKP-------I 115
            .||.||...||| |:....|.|....::..|.|.|   |:|...|...|     |.|       .
Mosquito    68 HSYGLDSNPSSEVEEEAGSDVEVMDESAQRNQMSNTLTSMYMNNRARAAGGGGPPVPDQSGSGAA 132

  Fly   116 SEPIDISSGDENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKKVAK-- 178
            .:.||||| ||.|.:.......|:|               ||  |:..|.|.|.....:|..:
Mosquito   133 GDAIDISS-DEEEGEGGGGGGEGEG---------------GS--KKATEAVSESVSGGEKFVQKF 179

  Fly   179 -PNTIHVSSSEAIQKLHQV----------------VGNRAKNLSEDAVPRSKDHR----NVPGLY 222
             ....||:    :.||.:|                |||.    .|...|.||..|    |..||.
Mosquito   180 VAGNRHVT----VTKLTRVNKTARDDDTSNGSVESVGNG----GEKFPPLSKRRRLELANSGGLV 236

  Fly   223 ------------------------QQLHQNQS-----------------RDRLRKFKRDLEVQHP 246
                                    .:.|..|:                 ..|.:||::::..:..
Mosquito   237 AGATNGQASRHPAGSGSKASHKPTNEQHNQQAGSGTPATPAAASSSAAGGQRSKKFRKEIVPRMV 301

  Fly   247 TESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMP 311
            ..:|.|:||||..||.|||:|:|:..||.|..|||.|.||.|||||||.|||.||:||:|||.:.
Mosquito   302 DITFDDVGGMDHILKNLCELLLHVIHPEIYRYLGLPPPRGFLLHGPPGSGKTLLAQAIAGQLNVR 366

  Fly   312 LMEIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLIS 376
            |:|:|||||:.|:|||||||||:||:||...|||||||||||||..||..|.||||||||:||:|
Mosquito   367 LIEVPATELVAGVSGESEERIRDVFEQAASLSPCVLFIDEIDAISSNRVNAQKDMERRIVAQLLS 431

  Fly   377 SLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILRIQCEGLSVDP 441
            |:|.|...|.|:.|:||.||.|.|.|||.|||:||||.||::.||.|:.|::||||.|..|.:..
Mosquito   432 SMDALGKQEGGEGVIVIGATNRADALDPALRRVGRFDQEISLGIPDREARKQILRIICWKLRISD 496

  Fly   442 KLNYDKIAELTPGYVGADLMALVSRAASVAVKRRS--------MKKFRELHAASEKNMTTVTLDD 498
            .::|.::|:||||||||||:||..|||:.|:||::        ..:..|..|..|.:..|...:.
Mosquito   497 TIDYGELAKLTPGYVGADLLALAIRAANNAIKRKNEPEQGVADSTQITEPVAPVEPDAATAPTET 561

  Fly   499 DEPSEDAGETPVPDSKGEETAKDAEAEQ-KVDGDK-ETSAKDKSEGDSPNIETPKKATNGNSSI- 560
            ...:|.|.......::.:.|..||:||: .||.|: .|::..:...|:...|..|:.|...|.|
Mosquito   562 TTETEPAAAASSEKTQEKVTTNDADAEKMDVDSDQLPTASTVEPPVDTAVAEAEKQVTVEQSDIA 626

  Fly   561 ----KSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKA--VEQEVDSSSSNDEYYEPTLAELTNFLD 619
                ||..:|.:: ||..|...:.    |.|.||:|  .:..|...||..:..|.||.:|.:.|.
Mosquito   627 MEETKSDNQTTEQ-AESSTTRVVP----AEEAPKEADGADTTVSKPSSVPQKQELTLQQLLDLLL 686

  Fly   620 NPPEEFADP-----NFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVL 679
            |  ::.|.|     ..|:...||::|:|.:||||||||||||||.||:|||:|..||||||||:|
Mosquito   687 N--QQNALPVTKLEGLCIERDDFIEALKTVQPSAKREGFITVPDVTWNDIGSLGDIREELKLAIL 749

  Fly   680 APVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAV 744
            ||||:|..|:.|||||||||||||||||||||||||:||||||||||||||||:|||||||||||
Mosquito   750 APVKFPHRLKLLGLTAPSGVLLCGPPGCGKTLLAKAVANEAGINFISVKGPELLNMYVGESERAV 814

  Fly   745 RACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNR 809
            |.|||||||||||||||||||||||||||..:| ::|||:||||||||||:||||||:::|||||
Mosquito   815 RQCFQRARNSAPCVIFFDEFDSLCPKRSDTAEG-SAGTRVVNQLLTEMDGIEERKGVFLMAATNR 878

  Fly   810 PDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADL 874
            |||:|||:|||||||.|||||.|.:.:|.:||:|.|||..:|.|||||:|:::|..|||||||||
Mosquito   879 PDIVDPAVLRPGRLDKILYVGLPAKEDRVDILRALTKNRTQPRLADDVELEKVAELTEGYTGADL 943

  Fly   875 AGLVKQASMFSLRQSL---------NNGDTNLDD---LCVRSQHFQEALQQLRPSVNEQDRKIYD 927
            ||||:|||:.:|:.|:         ..|:||.:|   |.||.:||.:|::.::|||..:|:|.|:
Mosquito   944 AGLVRQASLQTLKDSIVASSLQEETAGGETNAEDELSLMVRFEHFTQAIRNIKPSVTAEDKKHYE 1008

  Fly   928 KLRLKY 933
            ||||||
Mosquito  1009 KLRLKY 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	33/68 (49%)
		SpoVK	271..919	CDD:223540	380/681 (56%)
		AAA	287..418	CDD:278434	89/130 (68%)
		P-loop_NTPase	679..>716	CDD:304359	31/36 (86%)
		AAA	699..830	CDD:278434	113/130 (87%)
AgaP_AGAP006205	XP_316268.4	Nucleolin_bd	3..72	CDD:293330	33/68 (49%)
		SpoVK	327..1005	CDD:223540	382/685 (56%)
		AAA	343..471	CDD:278434	87/127 (69%)
		AAA	769..900	CDD:278434	114/131 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	243	1.000	Domainoid score	I5040
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1902
Inparanoid	1	1.050	829	1.000	Inparanoid score	I1352
OMA	1	1.010	-	-		QHG53526
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		otm49711
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2802
TreeFam	1	0.960	-	-
	13	12.940