DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and SPAST_ANOGA

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_312634.5	Gene:	SPAST_ANOGA / 1273633	VectorBaseID:	AGAP002334	Length:	827	Species:	Anopheles gambiae

Alignment Length:	973	Identity:	220/973 - (22%)
Similarity:	353/973 - (36%)	Gaps:	298/973 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 MMNSLYS------QPRKPLAPKPISEPIDISSGDENEDDSNTKTTNGDGVAAAAAPPPPTPAVQ- 155
            |:.:.|:      .|.|......:|:..| ::||   ||..|.|.:|.|.||.:.....|.|..
Mosquito     1 MVRNKYTLTTAGKSPSKKSRTGSLSKQHD-ATGD---DDGETGTLDGSGSAAGSPVGGGTDAAAK 61

  Fly   156 ----GSALKRLMEEV--PEIAV---------------------AAKKVAKP-----------NT- 181
                ||..|:.:..:  |.|.|                     ..|.|.:|           ||
Mosquito    62 RCDGGSVHKQNLYIISFPVIFVFNVLRSLLYQLFIVFRYVYNFTTKVVYRPVRKECGLEIVINTD 126

  Fly   182 --------IHVSSSEAIQK---LHQVVGNRAKNLSEDAVPRSKDHRNVPGLYQQLHQNQSRDRLR 235
                    .|..||.:|..   .||:..::.:...:.::.:.:.|.......||..|:|:...|:
Mosquito   127 QHGHHHHHHHRHSSHSIHSTAAAHQLQQHQQQQQHQYSLLQQEQHGVTEPQQQQQQQHQAAHPLQ 191

  Fly   236 KFK---------RDLEVQ--------------------HPTESFRDIG---GMDSTLKELCEMLI 268
            ..:         |::.:|                    |...:|..|.   .:|...::..|:.|
Mosquito   192 CSQSGILVNGEGREMSIQRSASGSQVGPGDPLLAKQKHHHRRAFEYISKALKIDEDNEDQKELAI 256

  Fly   269 HIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIR 333
            .:      ::.|:|.                |.|.|            |.|..|| .||..||.:
Mosquito   257 EL------YRKGILE----------------LERGI------------AVECWGG-RGEVWERAQ 286

  Fly   334 EVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIAA--- 395
            .:.|                               ::.:.|..:.|.|:.  .|...|.::.
Mosquito   287 RLHD-------------------------------KMQTNLSMARDRLQF--LGMLCVCVSVQRK 318

  Fly   396 ------TTRP--DV-----LDPGLRRIGRFDHEIAI---HIPSRKERREILRIQCEGLSVDPKLN 444
                  ||.|  ||     ..|...|:..|:....|   |.|:|.................|.|.
Mosquito   319 HLHPTRTTLPYRDVKSKLHTTPTENRMVSFNENCTITTNHHPARGTAASSRPTTAATAPATPSLP 383

  Fly   445 YDKIA------ELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSE 503
            ..:.|      :||.||         .|..::.|    |.|.:.|..:.....||       |:.
Mosquito   384 IKQTASEASGRKLTVGY---------KRPGNLGV----MNKSQTLPRSMGGTRTT-------PTG 428

  Fly   504 DAGETPVPDSKG-----------------EETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPK 551
            ..|...:....|                 :...|.|.....:  .::.|......|.||    .:
Mosquito   429 TGGAGGIAGGLGNGGTYGGSIVGGGAGMPKIVPKPAATPPAI--RRQFSVSIPIPGSSP----VR 487

  Fly   552 KATNGNSSIKSP---QKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAE 613
            ||:||..|..:|   .|||                :|.::|::..:|:......:.:..||.|.:
Mosquito   488 KASNGYGSKNTPPPRSKTP----------------LAGQQPQQPQQQQQQQPQISVKGVEPKLVQ 536

  Fly   614 LTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAV 678
            :                   ::|     ::::..||         ..|.||...|..::.|:..|
Mosquito   537 I-------------------IMD-----EIVEGGAK---------VQWQDIAGQEVAKQALQEMV 568

  Fly   679 LAPVKYPEMLERLGLTAPS-GVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESER 742
            :.|...||:.  .||..|: |:||.||||.||||||:|:|.|....|.|:....|.:.|||:.|:
Mosquito   569 ILPSVRPELF--TGLRTPAKGLLLFGPPGNGKTLLARAVATECSATFFSISAATLTSKYVGDGEK 631

  Fly   743 AVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGV---EERKGVYIL 804
            .|||.|..||...|.:||.||.||:..:||  .:.:.:..|:..:.|.:.||:   .|...:.::
Mosquito   632 LVRALFAVARELQPSIIFIDEVDSVLSERS--SNEHEATRRLKTEFLVQFDGLPANSEADRIVVM 694

  Fly   805 AATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGY 869
            ||||||..:|.|.||  |....:||..|::..|..:|:...:....|:  .|.||..:|..||||
Mosquito   695 AATNRPQELDEAALR--RFPKRVYVTLPDRDTRELLLRRLLQKQGSPL--SDADLAHLAQLTEGY 755

  Fly   870 TGADLAGLVKQASMFSLRQSLNNGDT-NLDDL---CVRSQHFQEALQQLRPSVNEQDRKIYDK 928
            :|:||..|.:.|::..:|: ||..:. |:|..   .:|...|..:|:::|.||..|....|:|
Mosquito   756 SGSDLTALARDAALEPIRE-LNVEEVKNMDPTKLRSIRESDFHNSLKRIRRSVAPQSLAAYEK 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	167/700 (24%)
		AAA	287..418	CDD:278434	25/146 (17%)
		P-loop_NTPase	679..>716	CDD:304359	19/37 (51%)
		AAA	699..830	CDD:278434	54/133 (41%)
SPAST_ANOGA	XP_312634.5	MIT_spastin	228..306	CDD:239142	23/145 (16%)
		P-loop_NTPase	551..>607	CDD:304359	26/57 (46%)
		AAA	584..721	CDD:214640	57/140 (41%)
		AAA	588..719	CDD:278434	55/134 (41%)
		Vps4_C	<794..823	CDD:286426	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900