DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and AgaP_AGAP000625

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_310453.2	Gene:	AgaP_AGAP000625 / 1271692	VectorBaseID:	AGAP000625	Length:	441	Species:	Anopheles gambiae

Alignment Length:	406	Identity:	127/406 - (31%)
Similarity:	186/406 - (45%)	Gaps:	94/406 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 KKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCL 632
            ||..:||   ..|.|..|.::..|.    .|||.|:.:               .||:
Mosquito    76 KKGKKKP---VKDGDGAAKDDKSKG----NDSSDSDSD---------------DPEK-------- 110

  Fly   633 TLIDFVDAIKVMQPSAKREGFITV--PDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTA 695
                     |.:|  ||.||.|.|  |...|.|:..||..:..||.||:.|:|:|.:.  .|...
Mosquito   111 ---------KKLQ--AKLEGAIVVEKPHVKWSDVAGLEGAKTALKEAVILPIKFPHLF--TGKRM 162

  Fly   696 P-SGVLLCGPPGCGKTLLAKAIANEA-GINFISVKGPELMNMYVGESERAVRACFQRARNSAPCV 758
            | .|:||.||||.||:.||||:|.|| ...|.||...:|::.::||||:.|:..|:.||...|.:
Mosquito   163 PWKGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLVSKWLGESEKLVKNLFELARAHKPSI 227

  Fly   759 IFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGV-EERKGVYILAATNRPDIIDPAILRPGR 822
            :|.||.||||..|||  :.:.|..||..:.|.:|.|| .:..||.:|.|||.|.|:|.||.|  |
Mosquito   228 VFIDEVDSLCSARSD--NESESARRIKTEFLVQMQGVGSDNDGVLVLGATNTPWILDSAIRR--R 288

  Fly   823 LDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLR 887
            .:..:|:..|::..|..:.|....|....:..|  :|..:|::|:|::|:|::.:|:.|.|..:|
Mosquito   289 FEKRIYIPLPDEHARLVMFKIHLGNTAHTLTED--NLRTLASKTDGFSGSDISIVVRDALMQPVR 351

  Fly   888 Q-------------SLNNGDTNLDDL---C------------------------VRSQHFQEALQ 912
            :             |..:..|..|||   |                        |......::|.
Mosquito   352 KVQTATHFKKVSGPSPVDKTTICDDLLVPCSPGDPGAIEMTWVDLPGDKLFEPPVTMNDMLKSLA 416

  Fly   913 QLRPSVNEQDRKIYDK 928
            ..:|:|||.|.|..||
Mosquito   417 STKPTVNEDDMKKLDK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	120/395 (30%)
		AAA	287..418	CDD:278434
		P-loop_NTPase	679..>716	CDD:304359	17/37 (46%)
		AAA	699..830	CDD:278434	59/132 (45%)
AgaP_AGAP000625	XP_310453.2	MIT_VPS4	5..69	CDD:239141
		P-loop_NTPase	130..>186	CDD:304359	26/57 (46%)
		AAA	163..299	CDD:214640	61/139 (44%)
		AAA	167..297	CDD:278434	59/133 (44%)
		Vps4_C	378..438	CDD:286426	11/55 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910