DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and AgaP_AGAP010924

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_309769.4	Gene:	AgaP_AGAP010924 / 1271027	VectorBaseID:	AGAP010924	Length:	1031	Species:	Anopheles gambiae

Alignment Length:	909	Identity:	212/909 - (23%)
Similarity:	354/909 - (38%)	Gaps:	253/909 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 APKPISEPIDISSGDENEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRLMEEVPEIAVAAKK 175
            |...|::|..:::.|..|...|.:.    .|.....|....|.|:.:  .||||:: ||....|.
Mosquito   286 ATMDINKPFLLTTNDNREYYVNVRL----AVDGERFPRNAYPTVEIN--DRLMEQL-EINHGEKV 343

  Fly   176 VAKP--NTIHVSSSEAIQKLHQVVGNR-AKNLSEDAVPRSKD---HRNVPGLYQQLHQNQSRDRL 234
            ..||  |.:::     :.::..:...: |..:.||.|.:.|.   |.:  .::..|...:...:|
Mosquito   344 TLKPIRNALNI-----VDRIELLPATKVAPIIEEDIVEKFKQFVLHNS--KIHALLLNQEQLFKL 401

  Fly   235 RKFKRDLEVQ-------------------------HPTESFRDIGG--------MDSTLKELCEM 266
            .::...|::|                         .|...:.|:.|        .|:...|.|:
Mosquito   402 PEYYLTLKLQPPALKYCLINSTILRHSKICCTGEVKPVAGYSDVDGSKKKPAALKDAESVEECK- 465

  Fly   267 LIHIKSPE---------FYFQLGL-----LPSR-GLLLHGPPGCGKTFLARAISGQLKMPLMEIP 316
            |:.|:..|         ..:.|.|     :|.: .:.:.|....|:    :.:...:...|.|:|
Mosquito   466 LVKIEKIERIVEECTDRLKYALCLDARCKVPQQCNMFIAGSSQSGR----KTVCDNILKRLAEVP 526

  Fly   317 ---------ATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIG---GNRQWASKDMERR 369
                     ..:..|......::.:|......:.:||.|||:|.:|.:.   |::.....:...:
Mosquito   527 FYCFSTTFDCAKHKGRKPDSIQKDLRHALYLCMFHSPAVLFMDGLDVLAHQPGDQNTPDAEYHNK 591

  Fly   370 IVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGL---RRIGRFDHEIAIHIPSRKERREILR 431
            :...:...::....|   ..:.|||:.:....|:..|   |....|...:.:....:.:|...|:
Mosquito   592 VSDMIRKQIEEFTGN---NPIAVIASISSSSNLNRRLHSSRGYHLFQQHVKLPNLDKADREAALK 653

  Fly   432 I-----QCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNM 491
            .     ||:   :|.::::.::|..|.||....|:.||.||...|.|:
Mosquito   654 SLFVQRQCK---LDRRIDWKRLANQTEGYAIGSLVQLVDRAVFYAYKQ----------------- 698

  Fly   492 TTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNG 556
                                                 ||
Mosquito   699 -------------------------------------DG-------------------------- 700

  Fly   557 NSSIKSPQKTPKKSAEKPTDAAMDVDN----VAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNF 617
                |.|..|     |.....|:||.|    |..|..|:....|::  ..:||.
Mosquito   701 ----KFPFVT-----EAMVSEALDVTNRYCLVGIENHKQQATDELE--EEDDEV----------- 743

  Fly   618 LDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPV 682
                                        |..|..|.          .||:|..:|.|    :.|.
Mosquito   744 ----------------------------PGDKVPGL----------EGAIEVFQEVL----MWPT 766

  Fly   683 KYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRAC 747
            ::|::.|...|...:|:||.||||.|||.|...:|....:..||||||||:..|:|:||..||..
Mosquito   767 RFPKIFEASPLRNQAGILLFGPPGTGKTYLVSKLAKTWNLRMISVKGPELLAKYIGQSEENVRNL 831

  Fly   748 FQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDI 812
            |.|||::.|||:||||||||.|:|  |.|......|:|||||||:||||..:||.::.||:||::
Mosquito   832 FDRARSAKPCVLFFDEFDSLAPRR--GHDSTGVTDRVVNQLLTELDGVEGLQGVTVIGATSRPEL 894

  Fly   813 IDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGL 877
            :|||:||.||:|.::....|..:.|.||.   :.:.|...|..||||.|.|.::|.|||||:..:
Mosquito   895 LDPALLRSGRIDRLVECTLPGVTARLEIF---SNHSKSLTLDKDVDLREFAVKSEYYTGADIRSI 956

  Fly   878 VKQASMFSLRQSLNNGDTNL-DDLCVRSQHFQEALQQLRPSVNEQDRKIYDKLRLKYAAPRVPT 940
            :..|:|.::::.|:|....: :.:.|..:|..||....|||::.:|...|.:...::.....|:
Mosquito   957 LTTANMLAVQECLSNDPEKVPEQITVSQRHLAEAFSSTRPSLSPRDIAKYRETYARFTNKEPPS 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	171/687 (25%)
		AAA	287..418	CDD:278434	23/145 (16%)
		P-loop_NTPase	679..>716	CDD:304359	15/36 (42%)
		AAA	699..830	CDD:278434	70/130 (54%)
AgaP_AGAP010924	XP_309769.4	PEX-1N	92..167	CDD:286361
		AAA	783..913	CDD:278434	70/131 (53%)
		AAA	783..910	CDD:214640	70/128 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810