DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and AgaP_AGAP006949

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_308807.4	Gene:	AgaP_AGAP006949 / 1270135	VectorBaseID:	AGAP006949	Length:	821	Species:	Anopheles gambiae

Alignment Length:	579	Identity:	168/579 - (29%)
Similarity:	243/579 - (41%)	Gaps:	137/579 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   422 SRKERREIL-RIQ--CEGLSVDPKLNYDKIAELTPGYVGADLMALVSRA-------------ASV 470
            |.|...|.| |||  ||    .|...::|..: .||...|......::|             ::.
Mosquito    45 SNKTWNEFLHRIQVFCE----KPPKGFEKYFK-PPGAASAQQAKQANKAGESGTSKDGSSSSSNS 104

  Fly   471 AVKRRSMKKFRELHAASEKNMTTVTLDDDEP------SEDAGETPVPDSKGEETAKD-------- 521
            |.::.:.:......|.|.||...:.:...:|      |..:|.:..|...|||..|:
Mosquito   105 AAEQSASQSNAPPGATSRKNDWNLGMFSPQPARGKGGSSGSGGSGRPIGGGEEGDKEKMLMFGAL 169

  Fly   522 ---------AEAEQKVDGDKETSAKD-----KSEGDSPNIE-----------TPKKATNGNS--- 558
                     |..|.   |.||.:.|:     .:.|....:|           ||..||:.:.
Mosquito   170 AGVALISAIAFFEM---GYKEIAWKEFVNNYLARGIVDKLEVVNKKWVRVKLTPGNATDSSGILW 231

  Fly   559 -SIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPP 622
             :|.|.....:......||..::..|..|    .....|:::||            ||..|..
Mosquito   232 FNIGSVDSFERNLESVQTDMNIEPVNFVP----VIYRSELEASS------------LTGLLPT-- 278

  Fly   623 EEFADPNFCLTLIDFVDAIKVMQPSAKREG-----------FITVPDTTWDDIGALEKIR----- 671
                     |.:|.|:  :.:|:.|::..|           |..|..:|...|.|.| |.
Mosquito   279 ---------LLIIGFL--VYMMRRSSEMMGGGRGGRRGGGLFGGVMQSTAKLINANE-INVGFKD 331

  Fly   672 ----EELKLAVLAPV---KYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKG 729
                ||.|:.::..|   |.|:....||...|.|.:|.||||.||||||||.|.||.:.||:|.|
Mosquito   332 VAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKATAGEANVPFITVSG 396

  Fly   730 PELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKR---SDGGDGNNSGTRIVNQLLTE 791
            .|.:.|:||.....||..|..||.:|||::|.||.|::..||   |.||......|  :||||.|
Mosquito   397 SEFLEMFVGVGPSRVRDMFAMARKNAPCILFIDEIDAVGRKRGGKSFGGHSEQENT--LNQLLVE 459

  Fly   792 MDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADD 856
            |||......|.:||||||.||:|.|:|||||.|..:||..|:...|..|.|...  |......|.
Mosquito   460 MDGFNTTTNVVVLAATNRVDILDKALLRPGRFDRQIYVPAPDIKGRASIFKVHL--GPLKTDLDK 522

  Fly   857 VDL-DEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQL 914
            .|| .::||.|.|:||||:|.:..:|::.:.| .||..        :..:||::|::::
Mosquito   523 TDLARKMAALTPGFTGADIANVCNEAALIAAR-DLNES--------IVMKHFEQAIERV 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	168/579 (29%)
		AAA	287..418	CDD:278434
		P-loop_NTPase	679..>716	CDD:304359	19/39 (49%)
		AAA	699..830	CDD:278434	68/133 (51%)
AgaP_AGAP006949	XP_308807.4	FtsH_ext	165..260	CDD:284011	17/97 (18%)
		FtsH_fam	272..766	CDD:273520	119/328 (36%)
		AAA	367..498	CDD:278434	68/132 (52%)
		Peptidase_M41	582..764	CDD:279742
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910