Protein Alignment smid and Vcp

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_446316.1
• Gene: Vcp / 116643
• RGDID: 621595
• Length: 806
• Species: Rattus norvegicus
• Alignment Length: 709
• Identity: 252/709 - (35%)
• Similarity: 365/709 - (51%)
• Gaps: 161/709 - (22%)

  Fly   238 KRDLEVQHPTE-SFRDIGGMDSTLKELCEML-IHIKSPEFYFQLGLLPSRGLLLHGPPGCGKTFL 300
            ||:.|.:...| .:.||||....|.::.||: :.::.|..:..:|:.|.||:||:||||.|||.:
  Rat   190 KREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLI 254

  Fly   301 ARAISGQLKMPLMEIPATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKD 365
            |||::.:.......|...|::..::||||..:|:.|::|...:|.::||||:|||...|:....:
  Rat   255 ARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGE 319

  Fly   366 MERRIVSQLISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREIL 430
            :||||||||::.:|.||..   ..|:|:|||.||:.:||.|||.||||.|:.|.||....|.|||
  Rat   320 VERRIVSQLLTLMDGLKQR---AHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEIL 381

  Fly   431 RIQCEGLSVDPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVT 495
            :|..:.:.:...::.:::|..|.|:|||||.||.|.||..|::               |.|..:.
  Rat   382 QIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIR---------------KKMDLID 431

  Fly   496 LDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSI 560
            |:|
  Rat   432 LED-------------------------------------------------------------- 434

  Fly   561 KSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEF 625
                                              :.:|             ||:.|.|
  Rat   435 ----------------------------------ETID-------------AEVMNSL------- 445

  Fly   626 ADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLER 690
                 .:|:.||..|:....|||.||..:.||..||:|||.||.::.||:..|..||::|:...:
  Rat   446 -----AVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLK 505

  Fly   691 LGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSA 755
            .|:|...|||..|||||||||||||||||...||||:|||||:.|:.||||..||..|.:||.:|
  Rat   506 FGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAA 570

  Fly   756 PCVIFFDEFDSLCPKRSDG-GDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILR 819
            |||:||||.||:...|... |||..:..|::||:||||||:..:|.|:|:.||||||||||||||
  Rat   571 PCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILR 635

  Fly   820 PGRLDTILYVGFPEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMF 884
            |||||.::|:..|::..|..||||..:  |.|| |.||||:.:|..|.|::||||..:.::|...
  Rat   636 PGRLDQLIYIPLPDEKSRVAILKANLR--KSPV-AKDVDLEFLAKMTNGFSGADLTEICQRACKL 697

  Fly   885 SLRQSLNNG--------------DTNLDDLC--VRSQHFQEALQQLRPSVNEQDRKIYD 927
            ::|:|:.:.              :...||..  :|..||:||::..|.||::.|.:.|:
  Rat   698 AIRESIESEIRRERERQTNPSAMEVEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYE 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247
		CDC48	<242..933	CDD:273521	250/705 (35%)
Vcp	NP_446316.1	CDC48	25..764	CDD:273521	252/709 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..727		1/18 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000250	797..806
		PIM motif. /evidence=ECO:0000250|UniProtKB:P55072	802..806